ID M3Y4R6_MUSPF Unreviewed; 319 AA.
AC M3Y4R6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Carbonic anhydrase {ECO:0000256|RuleBase:RU367011};
DE EC=4.2.1.1 {ECO:0000256|RuleBase:RU367011};
GN Name=CA6 {ECO:0000313|Ensembl:ENSMPUP00000006317.1,
GN ECO:0000313|RefSeq:XP_004768673.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000006317.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000006317.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004768673.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004768673.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Reversible hydration of carbon dioxide. Its role in saliva is
CC unknown. {ECO:0000256|ARBA:ARBA00025355}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544; EC=4.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000943,
CC ECO:0000256|RuleBase:RU367011};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU367011};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718, ECO:0000256|RuleBase:RU367011}.
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DR EMBL; AEYP01070413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01070414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01070415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004768673.1; XM_004768616.3.
DR STRING; 9669.ENSMPUP00000006317; -.
DR Ensembl; ENSMPUT00000006426.1; ENSMPUP00000006317.1; ENSMPUG00000006371.1.
DR GeneID; 101680019; -.
DR KEGG; mpuf:101680019; -.
DR CTD; 765; -.
DR eggNOG; KOG0382; Eukaryota.
DR GeneTree; ENSGT00940000160409; -.
DR HOGENOM; CLU_039326_1_0_1; -.
DR OMA; PPTMRMT; -.
DR OrthoDB; 49814at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF110; CARBONIC ANHYDRASE 6; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS00162; ALPHA_CA_1; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU367011};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367011};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Signal {ECO:0000256|RuleBase:RU367011};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367011}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|RuleBase:RU367011"
FT CHAIN 18..319
FT /note="Carbonic anhydrase"
FT /evidence="ECO:0000256|RuleBase:RU367011"
FT /id="PRO_5041007754"
FT DOMAIN 21..278
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
SQ SEQUENCE 319 AA; 36723 MW; BEA9D956F0A68061 CRC64;
MMALVALVAL LFLGAQAQHG SEWSYSEGAL DELHWPREYP TCGGRRQSPI NLERRKVQYN
PSLKALNLTG YGVQEGEFHM INNGHTVQIS LPPTMRMTAP DGTQYTAEQM HFHWGGASSE
IRGSEHTIDG IRFVAEIHIV HYNSKYESYD RAQSEPDGLA VLAALIEVKD HGENTYYSNF
IAHLNNIQYP GQSTVLSDLD ILHMLPGDIQ HYYSYNGSLT TPPCTENVHW FVLAHHVPLS
RAQIWKLENS ILDHHNKTLH NDYRSIQPLN NRVVETNLMN FPHLPYNLGP EFQLYIKKLN
KWFEFSRRLT EKRNKKDKF
//