ID M3Y721_MUSPF Unreviewed; 592 AA.
AC M3Y721;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=hyaluronan synthase {ECO:0000256|ARBA:ARBA00012207};
DE EC=2.4.1.212 {ECO:0000256|ARBA:ARBA00012207};
GN Name=HAS3 {ECO:0000313|Ensembl:ENSMPUP00000007125.1,
GN ECO:0000313|RefSeq:XP_004744591.2};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007125.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007125.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004744591.2}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004744591.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004698}.
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DR EMBL; AEYP01015902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01015903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01015904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01015905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004744591.2; XM_004744534.3.
DR STRING; 9669.ENSMPUP00000007125; -.
DR Ensembl; ENSMPUT00000007244.1; ENSMPUP00000007125.1; ENSMPUG00000007183.1.
DR GeneID; 101683617; -.
DR KEGG; mpuf:101683617; -.
DR CTD; 3038; -.
DR eggNOG; KOG2571; Eukaryota.
DR GeneTree; ENSGT00390000010337; -.
DR HOGENOM; CLU_029695_3_0_1; -.
DR OMA; RWARSTY; -.
DR OrthoDB; 1361850at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0036117; C:hyaluranon cable; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0050501; F:hyaluronan synthase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0085029; P:extracellular matrix assembly; IEA:Ensembl.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:Ensembl.
DR GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:1900106; P:positive regulation of hyaluranon cable assembly; IEA:Ensembl.
DR CDD; cd06434; GT2_HAS; 1.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22913; HYALURONAN SYNTHASE; 1.
DR PANTHER; PTHR22913:SF6; HYALURONAN SYNTHASE 3; 1.
DR Pfam; PF13641; Glyco_tranf_2_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 592 AA; 67536 MW; E6ECA0987B975166 CRC64;
MKGRFCCLGF REYPIQRTAP PRAAVGGRFP SPRRFCRMPV QLTTALRVVG TSLFALAVLG
GILAAYVTGY QFIHTEKHYL SFGLYGAILG LHLLIQSLFA FLEHRRMRRA GRPLKLPVPS
RSRRSVALCI AAYQEDPDYL RKCLRSAQRI AFADLKVVMV VDGNRQEDAY MLDIFHEVLG
GTEQAGFFVW RSNFHEAGDG ETEASLQEGM DRVRDVVRGS TFSCIMQKWG GKREVMYTAF
KALGDSVDYI QVCDSDTVLD PACTIEMLRV LEEDPQVGGV GGDVQILNKY DSWISFLSSV
RYWMAFNVER ACQSYFGCVQ CISGPLGMYR NSLLQQFLED WYHQKFLGSK CSFGDDRHLT
NRVLSLGYRT KYTARSKCLT ETPTKYLRWL NQQTRWSKSY FREWLYNSLW FHKHHLWMTY
ESVVTGFFPF FLIATVIQLF YRGRIWNILL FLLTVQLVGI IKATYACFLR GNAEMIFMSL
YSLLYMSSLL PAKIFAIATI NKSGWGTSGR KTIVVNFIGL IPVSIWVAVL LGGLAYTAYC
QDLFSETELA FLVSGAILYG CYWVALLMLY LAIIARRCGK KPEQYSLAFA EV
//
