ID M3Y8S7_MUSPF Unreviewed; 1305 AA.
AC M3Y8S7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=TDRD12 {ECO:0000313|Ensembl:ENSMPUP00000007734.1,
GN ECO:0000313|RefSeq:XP_004765273.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007734.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007734.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004765273.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004765273.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AEYP01062896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01062897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01062898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01062899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01062900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01062901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01062902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01062903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004765273.1; XM_004765216.3.
DR STRING; 9669.ENSMPUP00000007734; -.
DR Ensembl; ENSMPUT00000007858.1; ENSMPUP00000007734.1; ENSMPUG00000007791.1.
DR GeneID; 101671878; -.
DR KEGG; mpuf:101671878; -.
DR CTD; 91646; -.
DR eggNOG; KOG0331; Eukaryota.
DR GeneTree; ENSGT00420000029847; -.
DR HOGENOM; CLU_008124_0_0_1; -.
DR OMA; KMHKEVV; -.
DR OrthoDB; 5351296at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd20434; Tudor_TDRD12_rpt1; 1.
DR CDD; cd20435; Tudor_TDRD12_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047390; Tudor_TDRD12_rpt1.
DR PANTHER; PTHR22655:SF2; ATP-DEPENDENT RNA HELICASE TDRD12-RELATED; 1.
DR PANTHER; PTHR22655; UNCHARACTERIZED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00567; TUDOR; 2.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS51203; CS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Helicase {ECO:0000313|RefSeq:XP_004765273.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 1164..1250
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REGION 1093..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1305 AA; 147492 MW; 75EE844CE032E0A1 CRC64;
MLEVLVLKIE DPECFWVIIK GCSPFLDHEV DYQKLNSAMN DFYNNMCQDI EIKPLMLEEG
QVCVVYCQEL RCWCRAVIKS IVSSADHYLA ECFLVDFAKY IPVKSKNIRV AVETFMQLPY
RAKKFRLYCT KPVTLHIDFC EDSAEIVPTK KWDSAATQYF QNILKATTQV EAKLCAVEED
AFEVYLYATI KNEKVCVNDD LVAKNFARYI SPKENKNMDS VEKSSLSTKS ASFSRRLSPA
LTLWPMFLQG KDHQGMENSH GLTFLAQSLQ HPWPKGVVGD LGPTAMILDS TIKCRDSLRG
SPKKKSEKKQ EHILKDVNKC VKSSVYWPTK RGITIYAEPD VPATSALCQK PNEKPLRLAE
KKEHNEKNGC VKLLQFLNPD PLRADGIFDL QQLQRLRSGS QQPLAVLRNK IEPCLTVDTA
PLSADLRKAL QRNRFPGPSH TESYSWPPIA RGCDVVVISH CGKSPLLYLP PVLTILQTGG
CYKSLPSRNG PLAVIVCPGW KKAQFIFELL EDYSTSSRPL HPMLLTIGLH KDEAKNMKLP
RGCEVIVTTP HSLLRFLRYQ SLLFLRLCHL ILDEVEVLFS EASKEMFAIL DNFKKNIDIE
ERESAPHHIV AVGVHWSGHI EQLVKEFMND PYIVVTAMEE AALYGSVQQV VHLCLECEKT
STLLQTLDFI PSQAQKTLIF TGSVAETETV CKVIESSSVF CLKMHKEVVF NLKSVLEQWK
KKLSSGSHIV LALTDDCIPP LAITDATCVI HFSFPSSPKI FGGRLYCMSD HFQSSIEQGS
PAEQAEKKTK SVLLLTEKNA CHVVGVLRYL ERADAKIPSE LYEFTAGVLE AKEDKKARRP
LCPYLKAFGF CKDKRICPDR HHVNLEIDMP RKLSNQALPT FGYIKIIPFY ILNATHYFGR
IVDKQMDLYA SLNAEMNEYF KGNSNKMTVE KVEKLGLYGL AEKTLFHRVQ VLEMSQKEDT
WAADNVLVKF IDEGRTGLVT RGQLLHLPEN FHTLPPQAVE FIVCRVKPAD NEVEWNPKVT
RYIHHKIIGK LHDAKVILAL GNTVWIDPMV HITKLSNLKT SVIDYNVRTE ILSMGMGIDN
SEHIEQLKTF REGAKMPPGE EGPSQALAPS PADDAARLQS PQREDSGPEG GADSETKPEN
QKHETLPENT SDSSLPRTTE PLKSFHPQIK WFQKDDVVIL KIRIRNVKDY KCKYFQDRVV
FSGWAGEKFY LADMELQANV VKDACRCTIV NEEPVITLAK ETRGPWCGLL KQKNPNVAFD
FDHWEECEED SQLPQVVNSK NPPCTVAEVA ESSGQPSEDD GSESE
//