ID M3Y8Y4_MUSPF Unreviewed; 1259 AA.
AC M3Y8Y4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN Name=DCTN1 {ECO:0000313|Ensembl:ENSMPUP00000007791.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007791.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007791.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01010574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012906623.1; XM_013051169.1.
DR AlphaFoldDB; M3Y8Y4; -.
DR STRING; 9669.ENSMPUP00000007791; -.
DR Ensembl; ENSMPUT00000007916.1; ENSMPUP00000007791.1; ENSMPUG00000007849.1.
DR eggNOG; KOG0971; Eukaryota.
DR GeneTree; ENSGT00940000155378; -.
DR HOGENOM; CLU_002523_0_0_1; -.
DR InParanoid; M3Y8Y4; -.
DR OMA; LFEMEPV; -.
DR OrthoDB; 9423at2759; -.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0031252; C:cell leading edge; IEA:Ensembl.
DR GO; GO:0120103; C:centriolar subdistal appendage; IEA:Ensembl.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0000776; C:kinetochore; IEA:Ensembl.
DR GO; GO:0035371; C:microtubule plus-end; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0010457; P:centriole-centriole cohesion; IEA:Ensembl.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR GO; GO:0032402; P:melanosome transport; IEA:Ensembl.
DR GO; GO:0034454; P:microtubule anchoring at centrosome; IEA:Ensembl.
DR GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR GO; GO:0007528; P:neuromuscular junction development; IEA:Ensembl.
DR GO; GO:0050905; P:neuromuscular process; IEA:Ensembl.
DR GO; GO:0070050; P:neuron cellular homeostasis; IEA:Ensembl.
DR GO; GO:1990535; P:neuron projection maintenance; IEA:Ensembl.
DR GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR GO; GO:0051081; P:nuclear membrane disassembly; IEA:Ensembl.
DR GO; GO:0090063; P:positive regulation of microtubule nucleation; IEA:Ensembl.
DR GO; GO:1904398; P:positive regulation of neuromuscular junction development; IEA:Ensembl.
DR GO; GO:0060236; P:regulation of mitotic spindle organization; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR GO; GO:0021517; P:ventral spinal cord development; IEA:Ensembl.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701}.
FT DOMAIN 31..73
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 83..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 935..1026
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 114..133
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 139176 MW; 74A43AF1C9EDCB03 CRC64;
MSAEASARPL RVGSRVEVIG KGHRGTVAYV GATLFATGKW VGVILDEAKG KNDGTVQGRK
YFTCDEGHGI FVRQSQIQVF EDGADTTSPE TPDSSASKVL KREGTDSTAK TSKLRGLKPK
KAPTARKTTT RRPKPTRPAS TGVAGASSSL GPSGSASAGE LSSSEPSTPA QTPLAAPIIP
TPALTSPGAA PPLPSPSKEE EGLRAQVRDL EEKLETLRLK RAEDKAKLKE LEKHKIQLEQ
VQEWKSKMQE QQADLQRRLK EARKEAKEAL EAKERYMEEM ADTADAIEMA TLDKEMAEER
AESLQQEVEA LKERVDELTT DLEILKAEIE EKGSDGAASS YQLKQLEEQN ARLKDALVRM
RDLSSSEKQE HVKLQKLMEK KNQELEIVRQ QRERLQEELS QAESTIDELK EQVDAALGAE
EMVEMLTDRN LNLEEKVREL RETVGDLEAM NEMNDELQEN ARETELELRE QLDMAGARVR
EAQKRVEAAQ ETVADYQQTI KKYRQLTAHL QDVNRELTNQ QEASVERQQQ PPPETFDFKI
KFAETKAHAK AIEMELRQME VAQANRHMSL LTAFMPDSFL RPGGDHDCVL VLLLMPRLIC
KAELIRKQAQ EKFELSENCS ERPGLRGAAG EQLSFAAGLV YSLSLLQATL HRYEHALSQC
SVDVYKKVGS LYPEMSAHER SLDFLIELLH KDQLDETVNV EPLTKAIKYY QHLYSIHLAE
QPEDSTMQLA DHIKFTQSAL DCMSVEVGRL RAFLQGGQEA SDIALLLRDL ETSCSDIRQF
CKKIRRRMPG TDAPGIPAAL AFGAQVSDTL LDCRKHLTWV VAVLQEVAAA AAQLIAPLAE
NEGLPVAALE ELAFKASEQI YGTPSSSPYE CLRQSSNILI STMNKLATAM QEGEYDAERP
PSKPPPVELR AAALRAEITD AEGLGLKLED RETVIKELKK SLKIKGEELS EANVRLSLLE
KKLDSAAKDA DERIEKVQTR LEETQALLRK KEKEFEETMD ALQADIDQLE AEKAELKQRL
NNQSKRTIEG LRGPPPSGIA TLVSGIAGGG APGQAPGSVP GPGLVKDSPL LLQQISAMRL
HISQLQHENS ILKGAQMKAS LAALPPLHVA KLSPSPHEGP DSELAAGVLY RKTSQLLETL
NQLSTHTHVV DITRSSPAAK SPSAQLLEQV AQLKSLSDTI EKLKDEVLKE TVSQRPGATV
PTDFAIFPSS AFLRAKEEQQ DDTVYMGKVT FSCAAGLGQR HRLVLTQEQL HQLHGRLIS
//
