ID   M3Y955_MUSPF            Unreviewed;      1300 AA.
AC   M3Y955;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSMPUP00000007862.1};
GN   Name=EVC2 {ECO:0000313|Ensembl:ENSMPUP00000007862.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007862.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000007862.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
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DR   EMBL; AEYP01075002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01075003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004770595.1; XM_004770538.2.
DR   STRING; 9669.ENSMPUP00000007862; -.
DR   Ensembl; ENSMPUT00000007987.1; ENSMPUP00000007862.1; ENSMPUG00000007920.1.
DR   GeneID; 101689098; -.
DR   KEGG; mpuf:101689098; -.
DR   CTD; 132884; -.
DR   eggNOG; ENOG502QQ5U; Eukaryota.
DR   GeneTree; ENSGT00940000154127; -.
DR   HOGENOM; CLU_007621_0_0_1; -.
DR   InParanoid; M3Y955; -.
DR   OMA; IFFAQIK; -.
DR   OrthoDB; 4261679at2759; -.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0098797; C:plasma membrane protein complex; IEA:Ensembl.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   InterPro; IPR022076; Limbin.
DR   InterPro; IPR026501; Limbin/EVC.
DR   PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR   PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR   Pfam; PF12297; EVC2_like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1300
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004044873"
FT   TRANSMEM        288..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          28..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          778..806
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1152..1171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          454..481
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1300 AA;  146296 MW;  D6EFC002A55B0366 CRC64;
     MGSAGAAGRA TSVLAWSLLA AALALPAGPG GRRWHPAGPD LLGRPLGRQP PLDPPAAPGA
     GPERTTQDLP NLIWPNAESS GFKTAVGAPF GRKSSGRSEV FNPLLTSAPS RGPRTQSVLA
     FTPSWPKKTL FKRESPVTHR LFGDISRDVP GTAEDGVIFQ KCAVVSGQSE PQTAQVTLLV
     DNTRTPAATN LSDLLLFDNI TGLSVRGSTG NQTMPGFQAF RKKFLQVGDS FLVSYTASIK
     AGEVGSGEVL MLPAQLTFQS SAQNRTQLKA LFTITVEEKI KVVPNHGLHA AGFFAASIVS
     FVLTWVTLFF TARYQCLKGS LLTRHGVQHP ESKLEHSQFT SPDDVNEDLA LNDQMIDILS
     SEDPGSMLQA LEELEIATLN RADSDLEACR TQISRDIIAL LLKNLTSSGH LSPQVERRMG
     AVFKKQFLLL EKEIQEEYDR KMVALTAECD LEMRKKTESQ YQREMAAMEE AEELLKRVSE
     RSAVECNGLL RTLHSLEQVH LRRSLALQQE EDFAKAHRQL AVFQRNELHN IFFTQIKSAI
     FQGELKPEAA RMLLQDYANI QEKLEELMDF LQASKRYHLS KRFGHREYLV QNMQSSETRV
     QGLLSAADAQ LNLFIQKHER AGYLDEEQTE ALLGRTQTEV FSIRQKLDND LKQEKKKLHQ
     KLILKRRREM LQKHKEQRKE QLSLGEALRA AEDAGQYLGR WGSLLAEQGT ALETLQERLD
     QAALEELRAL TLSLSEKATE ELRRLQTSGM TQELLKRGVP WLFLQQILEE HSRELASRAQ
     QLEGEERDRD QEGVQSVRQR LKDDALEAST EEQAELRRWE HLIFMKLCSS AFSLSEDELL
     RLRQEVHGCF AQMDRSLALP KIRARALLQQ FQTAWREAEF RRLDQALAAP ELQQQSKARK
     PRSKSRSKID LLRKCIEDKI QLFEEQAPED LVEKVRGELL RERVQQLEAQ EACFAESLVS
     LQFQKAARMA TTLWAYTALL SIQDLLLEEL SESETLTKLA CEQILGSHSP ELQELERKLE
     DKLAQQEAAQ LQRALASRQQ WAGDGPGLLG MPEDTDSGRQ VSAVLQQALS QARKLLERQQ
     QSWREERDHS VVLEDLLENV EFDTFATLYS QELRLASYLS RLAMVPGGTL RRLLSVALPT
     ASQSELLAAL DPGSQKHPDH MVENNGGGEP ADLGRRRKHQ GWWQALESQL RGELISRGLE
     KMLWARERKE SILKKACPPL RERVIFPGKG SWPHLSLESI GELAAIPIIG AETIDLLNTG
     EKLFIFRNPK EPEISLHVPP KRKKKNFLNA KKATWALGMD
//