GenomeNet

Database: UniProt
Entry: M3Y9E3_MUSPF
LinkDB: M3Y9E3_MUSPF
Original site: M3Y9E3_MUSPF 
ID   M3Y9E3_MUSPF            Unreviewed;       616 AA.
AC   M3Y9E3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=Otopetrin 1 {ECO:0000313|Ensembl:ENSMPUP00000007950.1};
DE   SubName: Full=Proton channel OTOP1 {ECO:0000313|RefSeq:XP_004770623.1};
GN   Name=OTOP1 {ECO:0000313|Ensembl:ENSMPUP00000007950.1,
GN   ECO:0000313|RefSeq:XP_004770623.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007950.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000007950.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004770623.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004770623.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the otopetrin family.
CC       {ECO:0000256|ARBA:ARBA00006513}.
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DR   EMBL; AEYP01075033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004770623.1; XM_004770566.3.
DR   STRING; 9669.ENSMPUP00000007950; -.
DR   Ensembl; ENSMPUT00000008075.1; ENSMPUP00000007950.1; ENSMPUG00000008008.1.
DR   GeneID; 101672581; -.
DR   KEGG; mpuf:101672581; -.
DR   CTD; 133060; -.
DR   eggNOG; KOG4740; Eukaryota.
DR   GeneTree; ENSGT00940000159350; -.
DR   HOGENOM; CLU_032913_1_0_1; -.
DR   OMA; GNVCMRE; -.
DR   OrthoDB; 3682573at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015252; F:proton channel activity; IEA:Ensembl.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR   GO; GO:0009590; P:detection of gravity; IEA:Ensembl.
DR   GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0060336; P:negative regulation of type II interferon-mediated signaling pathway; IEA:Ensembl.
DR   InterPro; IPR004878; Otopetrin.
DR   PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR   PANTHER; PTHR21522:SF19; PROTON CHANNEL OTOP1; 1.
DR   Pfam; PF03189; Otopetrin; 3.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        72..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        97..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        275..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        546..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        580..601
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          501..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..47
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   616 AA;  67704 MW;  279CDB2CA2F82488 CRC64;
     MPEGQRVLVS PPAAARGALG RVSSGPSACP SPRLPVPGSP GYAGSPASPA PPRGAVRSSV
     PQKLAEALSS QYGLIVFVAG LLLLLAWAVH ASGVGKSDLL CFLTALMLLQ LVWMLWYVGR
     SSAHRRLISP KDTHAGARWL RGSITLFAAI TIILGCLKVG YFIGFSECLS ATEGVFPVTH
     AAHTLLQVYF LWGHAKDVIQ SFKTLERFGV IHSVFTNLLL WTNGVLNESK HQLNEHKERL
     ITLGFGNITI VLDDHTPPCN CSPPTFCSAI SQGIYYLYPF NIEYQILAST MLYVLWKNVG
     RKVDSQQHQN MEFKFPGVMA GSVLGLTVLA ATIGVVVVYL VQIGHSKIKS ELALIMFYLY
     AIALLMLMGA AGLLGIRIYR IDEKSLDESR NPARKLDADL LVSTASGSWL ISWGSILAIF
     CAEARPLYTW FNLPYSILVI AEKYIQNLFI IESIHREPEK LSEDIRTLRV VTVCNDDTIS
     LASSRLKSEA LATDVASLGR EMPHTANGNT HPRDGLGREA EERSQEGTPG PAGQPRFLQG
     DAKRRVLRNI AAFLFLCNIS LWIPPAFGCR PEYDNGLEEI VFGFEPWIIV VNLAMPFSIF
     YRMHAAASLF EVYCKI
//
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