ID M3Y9E3_MUSPF Unreviewed; 616 AA.
AC M3Y9E3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Otopetrin 1 {ECO:0000313|Ensembl:ENSMPUP00000007950.1};
DE SubName: Full=Proton channel OTOP1 {ECO:0000313|RefSeq:XP_004770623.1};
GN Name=OTOP1 {ECO:0000313|Ensembl:ENSMPUP00000007950.1,
GN ECO:0000313|RefSeq:XP_004770623.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007950.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007950.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004770623.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004770623.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
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DR EMBL; AEYP01075033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004770623.1; XM_004770566.3.
DR STRING; 9669.ENSMPUP00000007950; -.
DR Ensembl; ENSMPUT00000008075.1; ENSMPUP00000007950.1; ENSMPUG00000008008.1.
DR GeneID; 101672581; -.
DR KEGG; mpuf:101672581; -.
DR CTD; 133060; -.
DR eggNOG; KOG4740; Eukaryota.
DR GeneTree; ENSGT00940000159350; -.
DR HOGENOM; CLU_032913_1_0_1; -.
DR OMA; GNVCMRE; -.
DR OrthoDB; 3682573at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0009590; P:detection of gravity; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0060336; P:negative regulation of type II interferon-mediated signaling pathway; IEA:Ensembl.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR PANTHER; PTHR21522:SF19; PROTON CHANNEL OTOP1; 1.
DR Pfam; PF03189; Otopetrin; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 72..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..47
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 67704 MW; 279CDB2CA2F82488 CRC64;
MPEGQRVLVS PPAAARGALG RVSSGPSACP SPRLPVPGSP GYAGSPASPA PPRGAVRSSV
PQKLAEALSS QYGLIVFVAG LLLLLAWAVH ASGVGKSDLL CFLTALMLLQ LVWMLWYVGR
SSAHRRLISP KDTHAGARWL RGSITLFAAI TIILGCLKVG YFIGFSECLS ATEGVFPVTH
AAHTLLQVYF LWGHAKDVIQ SFKTLERFGV IHSVFTNLLL WTNGVLNESK HQLNEHKERL
ITLGFGNITI VLDDHTPPCN CSPPTFCSAI SQGIYYLYPF NIEYQILAST MLYVLWKNVG
RKVDSQQHQN MEFKFPGVMA GSVLGLTVLA ATIGVVVVYL VQIGHSKIKS ELALIMFYLY
AIALLMLMGA AGLLGIRIYR IDEKSLDESR NPARKLDADL LVSTASGSWL ISWGSILAIF
CAEARPLYTW FNLPYSILVI AEKYIQNLFI IESIHREPEK LSEDIRTLRV VTVCNDDTIS
LASSRLKSEA LATDVASLGR EMPHTANGNT HPRDGLGREA EERSQEGTPG PAGQPRFLQG
DAKRRVLRNI AAFLFLCNIS LWIPPAFGCR PEYDNGLEEI VFGFEPWIIV VNLAMPFSIF
YRMHAAASLF EVYCKI
//