ID M3YAK5_MUSPF Unreviewed; 1400 AA.
AC M3YAK5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Dispatched RND transporter family member 2 {ECO:0000313|Ensembl:ENSMPUP00000008362.1};
DE SubName: Full=Protein dispatched homolog 2 {ECO:0000313|RefSeq:XP_004751154.1};
GN Name=DISP2 {ECO:0000313|Ensembl:ENSMPUP00000008362.1,
GN ECO:0000313|RefSeq:XP_004751154.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000008362.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000008362.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004751154.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004751154.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dispatched family.
CC {ECO:0000256|ARBA:ARBA00038046}.
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DR EMBL; AEYP01028179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01028180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004751154.1; XM_004751097.2.
DR STRING; 9669.ENSMPUP00000008362; -.
DR Ensembl; ENSMPUT00000008497.1; ENSMPUP00000008362.1; ENSMPUG00000008426.1.
DR GeneID; 101675297; -.
DR KEGG; mpuf:101675297; -.
DR CTD; 85455; -.
DR eggNOG; KOG3664; Eukaryota.
DR GeneTree; ENSGT00940000159551; -.
DR HOGENOM; CLU_004076_1_1_1; -.
DR OMA; MPVTIVW; -.
DR OrthoDB; 2875706at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45951:SF2; PROTEIN DISPATCHED HOMOLOG 2; 1.
DR PANTHER; PTHR45951; PROTEIN DISPATCHED-RELATED; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 166..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..982
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 988..1010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1017..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1060..1083
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1095..1114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 505..641
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1400 AA; 151559 MW; 1A5177A86637CC5A CRC64;
MDAGSGGSSR GPAPGPGPEG EQRPKGEPLA PDGSSPDRSQ SKAVAPEASP EKSCSLQSGP
PEDPSSSSGP PPTTSTLQPV GPSSPLAPAH FTYPRAPQEY RGDNSLPGLG DRAALCSHGS
SLSPSPAPSQ RDGAWKPPSV QHHVVSVRQE RTFRMPKSYS QLIAEWPVAV LLLCLAVILV
CTLAGLLGDQ LPDFSKPLLG FEPRDTDIGR KLVVWRALQT LTGPRKLLSL SPDLEQNSSN
AHTTLSPTPW SSTQEGLVRP RRMVEPLEDR GQENFFCGPP EKSYAQLVFM STSAGSLWNL
HAIHSMCRME QEQIRSHSHF GALCQRTEAN KCCPSWSLGN YVAVLSNRSS CLDTTQADAA
RTLALLRACA IYYHRGALVP SCLGPGQDKP AHCTQVPTKC SRSSAVYQLL HFLLDRDFLS
PQTADYQVPS LKYSLLFLPT SKGASMMGIY LDRLAVPWGL SDNYTSITGM DLGLKQELLR
HYLAQDTVYP LLALVAIFLS IALYLRSLFL TLLVLLGVLG SLLVAFFLYR VAFRMAYFPF
VNLAAFVLLS SVCANHTLIF FDLWRLSKSQ LPSGGLAQRV GRTMHHFGYL LLVSGLTTAA
AFYASYLSRL PAVRCFALYL GTAVLAHLAL TLAWLPASAV LHERYLARAC ASRVQGPRAG
SAPRRLALAL HRRLRGLRRA AAGTSRLLFQ RLLPCGVIKF RYIWICWFAA LAAGGAYIAG
VSPRLRLPTL PPPRGQVFRP SHPFERFDAE YRQQFLFERL PQGEGGHLPV VLVWGVLPVD
TGDPLDPRSN SSLVSDPTFS ASGPEAQRWL LDLCHGAQNQ SFFGTQPEGW PTLCFMEALQ
RWVESPACAR LGPGLCCGHS AFPWAPQLFL HCLKMMALEQ GPNGTRDLGP RFNAHGSLAA
LVLQFQTNVQ YSPDYGQAHR FYTEVSHWLA AELGRAPPGL HRGWFTSHLE LYSLQHSLNT
EPAVVLGLAL ALAFATLLLG TWNVPLSLFS VAAVAGTVLL TVGLLVLLEW QLNTAEALFL
SASVGLSVDF TVNYCISYHL CPHPDRLSRV AFSLRQTSCA TAVGAAALFA AGVLMLPATV
LLYRKLGIVL MMVKCVSCGF ASFFFQSLCC FFGPEKNCGQ ILWPCAHLPW DTGTGESSGD
KAGRPRAGPT GGAPGSCSEQ YELQPLARRR SPSFDTSTAT SKLSHRPSVL SEDLQLHDGP
CCSRPPPAPA SPRELFLDHQ SVFSQCPALQ TSSPYKQAGS SPKTQGRRDS PGQKAEPARA
SPQVPAHSPK AKAVEPPDCL CSSASTLEGL SVSDETCLST SEPSARVPDS VGASPDDLDE
TEPTVPPERG QLNEKRDTLW LALREAVYDP SVPASHQSSS SWKGRGAPGD GSPVVLPNSQ
PDLPDVWLRR PSTHTSGYSS
//
