ID M3YFY9_MUSPF Unreviewed; 1066 AA.
AC M3YFY9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Neutral sphingomyelinase activation associated factor {ECO:0000313|Ensembl:ENSMPUP00000010246.1};
DE SubName: Full=Protein FAN isoform X1 {ECO:0000313|RefSeq:XP_004768844.1};
GN Name=NSMAF {ECO:0000313|Ensembl:ENSMPUP00000010246.1,
GN ECO:0000313|RefSeq:XP_004768844.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010246.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010246.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004768844.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004768844.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01070764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004768844.1; XM_004768787.3.
DR STRING; 9669.ENSMPUP00000010246; -.
DR Ensembl; ENSMPUT00000010409.1; ENSMPUP00000010246.1; ENSMPUG00000010320.1.
DR GeneID; 101674664; -.
DR KEGG; mpuf:101674664; -.
DR CTD; 8439; -.
DR eggNOG; KOG1786; Eukaryota.
DR GeneTree; ENSGT00940000155059; -.
DR HOGENOM; CLU_000218_5_2_1; -.
DR OMA; LLKFPGC; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0034250; P:positive regulation of amide metabolic process; IEA:Ensembl.
DR GO; GO:0045834; P:positive regulation of lipid metabolic process; IEA:Ensembl.
DR GO; GO:1905038; P:regulation of membrane lipid metabolic process; IEA:Ensembl.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF162; PROTEIN FAN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 335..432
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 436..721
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 859..889
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 908..949
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 950..991
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1031..1066
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1066 AA; 119665 MW; B3A890E8B0898F45 CRC64;
MGKHLSPCVQ QYKRRGAAGG EKGTLALQGQ TAGWPRPCPG PRGPECLGVS ERPSSGLSHG
AAGVPTRTCS AERGRDAAGP GAQRRAVGLW GAQRRHRTRS QARARAPLPA GTLQAGSPDP
PPSRVPDSSR TTAAPEPCVS ARCPPSMAFI RKKRREQQLQ LYSKERFSLL LLNLEEYYFE
QHTADHIQNK GGQYERKIRG SLKICSKSVI FEPDVISQPI IKIPLRDCIK IGKHGENGSN
RHFAKAKSGE ISLIFSQVYF IKEHNIVAPY KIERGKMEYV FELDVSGKVE DVVETLLQLH
RASCLDKLGD QTAMITAILQ SRLARTSFDK NRFQSVSEKL HMECKAEMVT PLVTNPGHVC
ITDTNLYFQP LNGYPKPVVQ ITLQDVRRIY KRRHGLMPLG LEVFCTEDDL CSDIYLKFYE
PQDRDDLYFY IATYLEHHVA ERTAESYTLQ WQRGHLSNYQ YLLHLNNLAD RSCNDLSQYP
VFPWIINDYC STELDLSNPG TFRDLSRPVG ALNKERLERL LTRYQEMPEP KFMYGSHYSS
PGYVLFYLVR IAPEYMLCLQ NGRFDNADRM FNSIAETWKN CLDGATDFKE LIPEFYGDDV
SFLVNSLKLD LGKRQGGQTV DDVELPPWAR SPEDFLQKSK DALESSYVSE HLHEWIDLVF
GYKQKGSDAV EAHNVFHPLT YEGGVDLNSI EDPDEKVAML TQILEFGQTP KQLFVTPHPR
RITPKLKTVT QACSPDDPMA DSPVSPGEES FEDLTEESKS LAWNNITKLQ LQEQYKIHKE
AVTGIAVSCN GSSVFTTSQD STLKMFSKES KMLQRSISFS NMALSSCLLL PGDATVISSS
WDNNVYFYSI AFARRQDTLM GHDDAVSKIC WHDNRLYSAS WDSTVKVWSG VPAEMTCTRR
QQFDMLAELE HDVSVDTISL NAASTLLVSG TKEGTVNIWD LTTATILHQI PCHSGTVCDT
AFSPDSRHVL STGKDGCLNV IDVQTGMLIS SLTSDETQRC FIWDGNSVLS GSQSGELLVW
DLLGGKISER IQGHAGAVTC IWMNEQCSSI ITGGEDRQIM FWKLQY
//
