GenomeNet

Database: UniProt
Entry: M3YG18_MUSPF
LinkDB: M3YG18_MUSPF
Original site: M3YG18_MUSPF 
ID   M3YG18_MUSPF            Unreviewed;       839 AA.
AC   M3YG18;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   28-MAR-2018, entry version 27.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSMPUP00000010275};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010275, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000010275}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000010275};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000010275}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEYP01079443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01079444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01079445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01079446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01079447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004772741.1; XM_004772684.2.
DR   STRING; 9669.ENSMPUP00000010275; -.
DR   Ensembl; ENSMPUT00000010439; ENSMPUP00000010275; ENSMPUG00000010349.
DR   GeneID; 101689588; -.
DR   CTD; 535; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; M3YG18; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0016241; P:regulation of macroautophagy; IEA:Ensembl.
DR   GO; GO:1901998; P:toxin transport; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    408    432       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    452    471       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    570       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    576    600       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    641    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    743    766       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    772    795       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   839 AA;  96427 MW;  FDE1402B810A84CE CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG ELGKVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIRKANIPIM DTGENPEVPF PRDMIDLEAN FEKIENELKE INTNQEALKR
     NFLELTELKF ILRKTQQFFD EAELHHQQMA DPDLLEESSS LLEPSEMGRG TPLRLGFVAG
     VINRERIPTF ERMLWRVCRG NVFLRQAEIE NPLEDPVTGD HVHKSVFIIF FQGDQLKNRV
     KKICEGFRAS LYPCPETPQE RKEMASGVNT RIDDLQMVLN QTEDHRQRVL QAAAKNIRVW
     FIKVRKMKAI YHTLNLCNID VTQKCLIAEV WCPVTDLDSI QFALRRGTEH SGSTVPSILN
     RMQTNQTPPT YNKTNKFTYG FQNIVDAYGI GTYREINPAP YTIITFPFLF AVMFGDFGHG
     ILMTLFAVWM VLRESRILSQ KNENEMFSTV FSGRYIILLM GVFSIYTGLI YNDCFSKSLN
     IFGSSWSVRP MFTLYNWTEE TLRGNPVLQL NPSVPGVFGG PYPFGIDPIW NIATNKLTFL
     NSFKMKTSVI LGITHMMFGV TLSLFNHTYF KKPLNIYFGF IPEIIFMTSL FGYLVILIFY
     KWTAYNANTS EKAPSLLIHF INMFLFSYGD SSNSMLYSGQ KGIQCFLVVV ALLCVPWMLL
     FKPLVLRHQY LRKKHLGTLN FGGIRVGNGP TEEDAEIIQH DQLSTHSEDA EEFDFGDTMV
     HQAIHTIEYC LGCISNTASY LRLWALSLAH AQLSEVLWTM VIHIGLSVKS LAGGLALFFI
     FAAFATLTVA ILLIMEGLSA FLHALRLHWV EFQNKFYSGT GFKFLPFSFE HIREGKFDE
//
DBGET integrated database retrieval system