ID   M3YHF4_MUSPF            Unreviewed;       936 AA.
AC   M3YHF4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=MutS homolog 4 {ECO:0000313|Ensembl:ENSMPUP00000010761.1};
GN   Name=MSH4 {ECO:0000313|Ensembl:ENSMPUP00000010761.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010761.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000010761.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
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DR   EMBL; AEYP01045765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01045766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01045767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01045768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01045769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01045770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01045771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01045772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3YHF4; -.
DR   STRING; 9669.ENSMPUP00000010761; -.
DR   Ensembl; ENSMPUT00000010940.1; ENSMPUP00000010761.1; ENSMPUG00000010849.1.
DR   eggNOG; KOG0220; Eukaryota.
DR   GeneTree; ENSGT00550000074897; -.
DR   HOGENOM; CLU_002472_7_2_1; -.
DR   InParanoid; M3YHF4; -.
DR   OMA; KMTMLYK; -.
DR   GO; GO:0005713; C:recombination nodule; IEA:Ensembl.
DR   GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0007292; P:female gamete generation; IEA:Ensembl.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:Ensembl.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   CDD; cd03243; ABC_MutS_homologs; 1.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          754..770
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   936 AA;  104738 MW;  89D6A630807E0034 CRC64;
     MRRSEVSTVS PSVPAASLAL GEPRSQGPYN FGLQETPQSG PSAQASASTT SGTSAAAGDR
     SSSTSLPRHP PGAGPALGSH FRNKRSNAEN TFASNFNFGT SSSSTRDSNY PQILKTPLSA
     GNPQRSGYKN WTPQMGYSEK LTAPSSSAVS TNSPSVVAAV VEGRGLARGE IGMASIDLKS
     PQIILSQFAD NTTYAKVITK LKILSPLEII MSNTACVVGN STKLFTLITE NFKNVNFTTI
     QRKYFNETKG LEYIEQLCVT EFSTVLMEVQ SKYYCLAAVA ALLKYVEFIQ NSVYAPKSLK
     ICFQGSEQTA MIDSSSAQNL ELLINNQDSR NNHTLFGVLN YTKTPGGSRR LRSNILEPLV
     DIETINMRLD CVQELLQDEE LFFGLQSVIS RFLDTEQLLS VLVQIPKQDT VNAAESKITN
     LIYLKHTLEL VDPLKIALRN CSTPLLRAYC GSLEDKRFGI ILEKIKTIIN DDARYMKGCL
     NMRTQKCYAV RSNINEFLDI ARRTYTEIVD DIAGMISQLA EKYSLPLRTS FSSARGFFIQ
     MTTDYTALPN NRLPSEFIKI SKVKSSYTFT SADLIKMNER CQESLREIYH MTYMIVCKLL
     SEIYEHIHCL YKLSDTVSML DMLLSFAHAC TLSDYVRPEF TDTLAIKQGW HPILEKISVE
     KPIANNTYIT EGSNFLIITG PNMSGKSTYL KQIALCQIMA QIGSYVPAEY SSFRIAEQIF
     TRISTDDEIE TNSSTFMKEM KEIAYILHNA NNKSLILIDE LGRGTNTEEG IGICYAVCEY
     LLSLKAFTLF ATHFLELCHI EVLYPNVENM HFEVQHVKNT SRDKEAILYT YKLCKGLTEE
     KNYGLKAAEV SSLPSSIVLD AKEITTQITR QTLQNQRSTP EMERQRAVYH LATRLVQTAR
     NSQLDPDSLR MYLSNLKKKY EIDFSRAEQV SGKTEE
//