ID M3YHM3_MUSPF Unreviewed; 572 AA.
AC M3YHM3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Keratin 14 {ECO:0000313|Ensembl:ENSMPUP00000010830.1};
GN Name=KRT14 {ECO:0000313|Ensembl:ENSMPUP00000010830.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010830.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010830.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AEYP01079496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01079497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01079498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YHM3; -.
DR STRING; 9669.ENSMPUP00000010830; -.
DR Ensembl; ENSMPUT00000011009.1; ENSMPUP00000010830.1; ENSMPUG00000010916.1.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000154602; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR InParanoid; M3YHM3; -.
DR OMA; TLNKEMA; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF368; KERATIN, TYPE I CYTOSKELETAL 14; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}.
FT DOMAIN 124..435
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 432..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 128..162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 234..420
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 441..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 57856 MW; A2C2817EBD2FE4DA CRC64;
LGTMTTCSRQ FTSSSSMKGS CGIGGGSSRM SSVLAGGSCR APSAYGGLSV SSSRYSSGGA
CGLGGGYGGG FSSSSSFGGG LGSGFGGGYG GGLGAGFGGG FGGGLGAGFG GGFGGGDGLL
VGSEKVTMQN LNDRLASYLD KVRALEEANA DLEVKIRDWY QRQRPAETKD YSPYFKTIED
LRNKILTATV DNANVLLQID NARLAADDFR TKYETELNLR MSVEADTNGL RRVLDELTLS
RADLEMQIES LKEELAYLKK NHEEEMNSLR GQVGGDVNVE MDAAPGVDLS RILNEMRDQY
EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI SELRRTVQNL EIELQSQLSM
KASLENSLEE TKGRYCMQLA QIQDLIGNVE EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE
IATYRRLLEG EDAHYGGGSS SGGGSGGNYG GGSSSGGGSG GKGGSGGSYG GGGSGGSYGG
GSSSGGGSGG SYGGGSSSGG GSGGRRGSGG SYGGGISSGG GSRGSYGGGS SSGGGSGGRG
GSGGSYGGGS STGGGSGSSY GGGSSSGGGS GS
//
