ID M3YHS8_MUSPF Unreviewed; 839 AA.
AC M3YHS8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 6 {ECO:0000313|Ensembl:ENSMPUP00000010885.1};
GN Name=PCSK6 {ECO:0000313|Ensembl:ENSMPUP00000010885.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010885.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000010885.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
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DR EMBL; AEYP01050103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01050104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01050105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01050106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YHS8; -.
DR STRING; 9669.ENSMPUP00000010885; -.
DR Ensembl; ENSMPUT00000011067.1; ENSMPUP00000010885.1; ENSMPUG00000010974.1.
DR eggNOG; KOG3525; Eukaryota.
DR GeneTree; ENSGT00940000159506; -.
DR HOGENOM; CLU_002976_3_0_1; -.
DR InParanoid; M3YHS8; -.
DR OMA; CSTCTGQ; -.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0048406; F:nerve growth factor binding; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0009100; P:glycoprotein metabolic process; IEA:Ensembl.
DR GO; GO:0032902; P:nerve growth factor production; IEA:Ensembl.
DR GO; GO:0016486; P:peptide hormone processing; IEA:Ensembl.
DR GO; GO:0032940; P:secretion by cell; IEA:Ensembl.
DR GO; GO:0007354; P:zygotic determination of anterior/posterior axis, embryo; IEA:Ensembl.
DR CDD; cd00064; FU; 4.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR010909; PLAC.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF8; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 365..505
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT DOMAIN 801..839
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 528..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 75
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 116
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 290
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 839 AA; 93168 MW; DA735874117C1540 CRC64;
MDPQVKWLQQ QEVKRRVKRQ VRSDPQALYF NDPIWSNMWY MHCGDKNSRC RSEMNVQAAW
KKGYTGKNVV VTILDDGIER NHPDLAPNYD SYASYDVNGN DYDPSPRYDA SNENKHGTRC
AGEVAASANN SYCIVGIAYN AKIGGIRMLD GDVTDVVEAK SLGIRPNYID IYSASWGPDD
DGKTVDGPGR LAKQAFEYGI KKGRQGLGSI FVWASGNGGR EGDHCSCDGY TNSIYTVSVS
STTENGYKPW YLEECASTLA TTYSSGAFYE RKIVTTDLRQ RCTDGHTGTS VSAPMVAGII
ALALEANNQL TWRDVQHLLV KTSRPAHLKA NDWKVNGAGH KVSHLYGFGL VDAEALVTEA
KKWTAVPAQH MCVATTDKRP RSIPVVQTLR TTTLTTACAD HSDQRVSYLE HVVARISISH
PRRGDLQIHL ISPSGTKSQL LAKRLLDHSN EGFTNWEFMT VHCWGEKAEG EWTLEIQDMP
SQVRNPEKQG KLKEWSLILY GTAEHPYNTF SSHQSRSRML ELSAPVLEPP KAALSPPQTE
VPEDEEDYTA PSTHGSPNIL QTSLCHPECG DKGCDGPKAD QCLNCVHFSL GSAKTSRKCV
SVCPLGYFGD TTARRCRRCY KGCETCSGRS PTQCLSCRRG FYHHQEMNTC VTFCPAGFYA
DESQKNCLKC HPSCKKCVDE PEKCTVCKEG FSFARGSCIP DCEPGTYFDS ELIRCGECHH
TCQTCVGPSR EECIHCAANF HFQDWKCVPA CGEGFYPEEM LGLPHKVCRR CDESCLSCEG
SSRNCSRCKT GFTLLGSTCI TNHTCSNADE TFCEMVKSNR LCERKLFIQF CCRTCLLAG
//
