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Database: UniProt
Entry: M3YIL7_MUSPF
LinkDB: M3YIL7_MUSPF
Original site: M3YIL7_MUSPF 
ID   M3YIL7_MUSPF            Unreviewed;      1436 AA.
AC   M3YIL7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=NACHT, LRR and PYD domains-containing protein 1 isoform X2 {ECO:0000313|RefSeq:XP_004760529.1};
DE   SubName: Full=NLR family pyrin domain containing 1 {ECO:0000313|Ensembl:ENSMPUP00000011174.1};
GN   Name=NLRP1 {ECO:0000313|Ensembl:ENSMPUP00000011174.1,
GN   ECO:0000313|RefSeq:XP_004760529.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011174.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000011174.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004760529.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004760529.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC       {ECO:0000256|ARBA:ARBA00004110}.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   EMBL; AEYP01050968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004760529.1; XM_004760472.3.
DR   STRING; 9669.ENSMPUP00000011174; -.
DR   Ensembl; ENSMPUT00000011362.1; ENSMPUP00000011174.1; ENSMPUG00000011266.1.
DR   GeneID; 101679990; -.
DR   CTD; 22861; -.
DR   eggNOG; ENOG502S4A4; Eukaryota.
DR   GeneTree; ENSGT00940000162176; -.
DR   HOGENOM; CLU_002274_2_4_1; -.
DR   OMA; VELWEKW; -.
DR   OrthoDB; 338452at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0072558; C:NLRP1 inflammasome complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR   GO; GO:0140608; F:cysteine-type endopeptidase activator activity; IEA:Ensembl.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR   GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR   GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR   GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR   GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:1904784; P:NLRP1 inflammasome complex assembly; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR   GO; GO:0070269; P:pyroptosis; IEA:Ensembl.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0097264; P:self proteolysis; IEA:Ensembl.
DR   GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IEA:Ensembl.
DR   CDD; cd08330; CARD_ASC_NALP1; 1.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR025307; FIIND_dom.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00619; CARD; 1.
DR   Pfam; PF13553; FIIND; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 6.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS51830; FIIND; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          1..92
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          293..601
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   DOMAIN          1039..1321
FT                   /note="FIIND"
FT                   /evidence="ECO:0000259|PROSITE:PS51830"
FT   DOMAIN          1331..1420
FT                   /note="CARD"
FT                   /evidence="ECO:0000259|PROSITE:PS50209"
FT   REGION          95..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          164..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          950..1007
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1016..1035
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..232
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        970..984
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        986..1002
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1436 AA;  160706 MW;  EAAE05ED1FA12FB6 CRC64;
     MASGVQWRLA RYLDMLGKEE LKEFQLRLPE KPLGGPRPHL TSACGQQPGA LEAASQLVAQ
     HGEQQAWDLA LHTWEQMGLS QLCAQARAEA ALMSGEGSSL PCSPGAPSMQ SPSGPTSTVV
     LSFVQDPPTT SSKQPPGTSR CFLQNRYPSF SFNRVLPCSS NQKSLLQESP SAPTSTTVLE
     DWVPPPQFSR KPRKQEAPRA EWLLVEMSGE HSKGIRERRQ HQKRKRPRPT KSRGKEGLHE
     EFIELLLLHQ PRGGLLESQS KGSWHHSGAE EQGRLIEVKD LFGPGLGAQE EGRAVVLHGV
     AGVGKSVMAR QVRRAWEEGR LYRDRFQHVF YFSCRQLAQS KTMSLKELIT KDWAAPTAPS
     EQILSQPGQL LLILDGLDEL KWVFVKEKSE VCPYWDQPQP VKTLLLGLLR KTILPGASLL
     ITARTTALHL FILSVEQPRW VKVLGFSESS RKEYFYKYFK SKNKANRAFH SVELNQPLLT
     MCLVPLVSWL VCTCMKKQME RGESLGLPSQ TATALCLHYL AQALPAQPLG TQLRGLCSLA
     AKGIRQRETL LIWEDLRKHE LEDTVSALLE MGILRKHPSS PDYDFAHQYL QEFFAAVSCV
     LGSEDKECHP PDSIQGLEDL LKAYGGLDPF GVPPTCFVLG LLSEPVQREM EAVFQGKVPA
     ERKRKLLCWA KEAVRNQLPV LQQSSLPMLH CLYEIQDKDF LTHAMAPFHG ARVRVHTSLE
     LLVFMFCIKF CTVKELRLNE RGQHGHTGSP LHVALLRGFP VTDAWWEVLF FTLRTTGKLK
     ELDLSGNCLS NTVVQSLCKA LRFPSCCLET LRLTHCSLTA EGCIGLAWVL DTPETLTELE
     LSFNLLLDLG VERLCNGLKE PGCRLHRLRL VGCGLTSRCC RALASALSAS PRLTELDLQQ
     NELEDAGVRL LCEGLRRPTC QLRLLWLDQT GLSEEVTRML RALEDEKPPL LIPSRWKPSE
     TMPNEGPRET VPNEDPRETM PNEGPHEGET SGTSSLQQDR RESEGLSPPV VQEGLVGLLS
     PAPPEDLQHK GPLGTEDDFW GPLGPVTIEM VDKDRSLHRV HLPMAGSYRW PSTGLRFVVR
     EPATIDIEFC ASDKFLHQMA WEQSWMVVGP LFDIKVKPGA VATVYLPHFV DLRGGCVDTS
     LFQVAHFKEP GMLLEKPTRV ELYHVVLEDP SFSPLGVFLR TIHAALRFLP ITSMVLLYHH
     TRPDETVFHL YLIPSDCCVR KAIDDEEKAF QFVQIRKPPP LGSLYLGSRY TVSSSETLEA
     IPKELELCYR SPGQPQLYSE FYVGDLGSGL RLQLKDGSGA VVWEALVKPG DLQLTSSLVP
     PAPAASPAPP GAPASLHFLD RHREQLVARV TTVDPVLDKL LGQVLSEEQY ERVRAKATAA
     NQMRELFRFS RSWDPACKDQ VYQALKETHP YLIMELWETW GGDRERGTSP PTQPLP
//
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