ID M3YIR1_MUSPF Unreviewed; 269 AA.
AC M3YIR1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=Transcription initiation factor IIE subunit beta {ECO:0000256|PIRNR:PIRNR016398};
GN Name=GTF2E2 {ECO:0000313|Ensembl:ENSMPUP00000011218.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011218.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011218.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Recruits TFIIH to the initiation complex and stimulates the
CC RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase
CC activities of TFIIH. Both TFIIH and TFIIE are required for promoter
CC clearance by RNA polymerase. {ECO:0000256|ARBA:ARBA00025581,
CC ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC {ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SIMILARITY: Belongs to the TFIIE beta subunit family.
CC {ECO:0000256|PIRNR:PIRNR016398}.
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DR EMBL; AEYP01043962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YIR1; -.
DR STRING; 9669.ENSMPUP00000011218; -.
DR Ensembl; ENSMPUT00000011406.1; ENSMPUP00000011218.1; ENSMPUG00000011310.1.
DR eggNOG; KOG3095; Eukaryota.
DR GeneTree; ENSGT00390000011749; -.
DR HOGENOM; CLU_086770_0_0_1; -.
DR InParanoid; M3YIR1; -.
DR OMA; HMKARHQ; -.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR GO; GO:0005673; C:transcription factor TFIIE complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:Ensembl.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR CDD; cd07977; TFIIE_beta_winged_helix; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR040501; TFA2_Winged_2.
DR InterPro; IPR016656; TFIIE-bsu.
DR InterPro; IPR003166; TFIIE_bsu_DNA-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12716:SF8; TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA; 1.
DR PANTHER; PTHR12716; TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT; 1.
DR Pfam; PF18121; TFA2_Winged_2; 1.
DR Pfam; PF02186; TFIIE_beta; 1.
DR PIRSF; PIRSF016398; TFIIE-beta; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51351; TFIIE_BETA_C; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016398};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016398};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR016398};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR016398}.
FT DOMAIN 66..146
FT /note="TFIIE beta"
FT /evidence="ECO:0000259|PROSITE:PS51351"
FT REGION 17..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 269 AA; 30405 MW; 3AC22CF6538E3E37 CRC64;
MDPSLLRERE LFKKRALSTP VVEKRSVSSE SSSSSSKKKK AKLEHGGSSG SKQNSDHSNG
SFNLKALSGS SGYKFGVLAK IVNYMKTRHQ RGDTHPLTLE EILDETQHLD IGLKQKQWLM
TEALVNNPKI EVIDGKYAFK PKYNLKDKKA LLRLLDKHDQ RGLGGILLED IEEGLPNSQK
AVKALGDQIL FVNRPDKKKI LFFNDKSCQF SVDEEFQKLW RSVTVDSMDE EKIEEYLKRQ
GISSMQESGP KKVAPLTPHP IKSKKNQKP
//
