ID M3YJ70_MUSPF Unreviewed; 470 AA.
AC M3YJ70;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Iduronate 2-sulfatase {ECO:0000313|Ensembl:ENSMPUP00000011377.1, ECO:0000313|RefSeq:XP_004777987.1};
GN Name=IDS {ECO:0000313|Ensembl:ENSMPUP00000011377.1,
GN ECO:0000313|RefSeq:XP_004777987.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011377.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011377.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004777987.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004777987.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; AEYP01092997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004777987.1; XM_004777930.3.
DR STRING; 9669.ENSMPUP00000011377; -.
DR Ensembl; ENSMPUT00000011565.1; ENSMPUP00000011377.1; ENSMPUG00000011467.1.
DR GeneID; 101690645; -.
DR CTD; 3423; -.
DR eggNOG; KOG3867; Eukaryota.
DR GeneTree; ENSGT00940000156803; -.
DR HOGENOM; CLU_006332_9_0_1; -.
DR OMA; HVFTRAY; -.
DR OrthoDB; 2964021at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0043202; C:lysosomal lumen; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0004423; F:iduronate-2-sulfatase activity; IEA:Ensembl.
DR GO; GO:0030209; P:dermatan sulfate catabolic process; IEA:Ensembl.
DR GO; GO:0030200; P:heparan sulfate proteoglycan catabolic process; IEA:Ensembl.
DR CDD; cd16030; iduronate-2-sulfatase; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR035874; IDS.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR45953; IDURONATE 2-SULFATASE; 1.
DR PANTHER; PTHR45953:SF1; IDURONATE 2-SULFATASE; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
DR PROSITE; PS00149; SULFATASE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..470
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041198525"
FT DOMAIN 36..413
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
SQ SEQUENCE 470 AA; 52356 MW; AAA871A9F35BCD3B CRC64;
MPPAGWCLLW LGLLLASVCT SLESAASGNS TTAPLNVLLI IVDDLRPSLG CYGDKLVRSP
NIDQLASHSL LFQNAFAQQA VCAPSRVSFL TGRRPDTTRL YDFNSYWRVH AGNFSTIPQH
FKENGYVTMS VGKVFHPGIS SNYSDDSPFS WSVPPYHPSS EKYENTKTCR GPDGKLHANL
LCPVDVADVP EGTLPDKQST EQAIRLLEKM KTSARPFFLA VGYHKPHIPF RYPKEFQKLY
PLENITLAPD PQVPAGLPPV AYNPWMDIRQ REDVQALNLS VPYGPIPADF QRKIRQSYFA
SVSYLDTQVG HLLSALDDLQ LANSTIIAFV SDHGWALGEH GEWAKYSNFD VATRVPLMFY
VPGRTAPLLE AGEKLFPYID PFDSIVELME PGQQVTDLVE LLSLFPTLAG LAGLHVPPRC
PVPSFRVAQC REGQSLVKYF RFQDLDEDQY LPGMVGCRYT FIQEAGNNLL
//
