ID M3YJE8_MUSPF Unreviewed; 1024 AA.
AC M3YJE8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Histone lysine demethylase PHF8 isoform X1 {ECO:0000313|RefSeq:XP_004780646.1, ECO:0000313|RefSeq:XP_004780649.1};
DE SubName: Full=PHD finger protein 8 {ECO:0000313|Ensembl:ENSMPUP00000011455.1};
GN Name=PHF8 {ECO:0000313|Ensembl:ENSMPUP00000011455.1,
GN ECO:0000313|RefSeq:XP_004780646.1, ECO:0000313|RefSeq:XP_004780649.1,
GN ECO:0000313|RefSeq:XP_004780651.1, ECO:0000313|RefSeq:XP_044928707.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011455.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004780646.1, ECO:0000313|RefSeq:XP_004780649.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004780646.1,
RC ECO:0000313|RefSeq:XP_004780649.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01100742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01100743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01100744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01100745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01100746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01100747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004780646.1; XM_004780589.3.
DR RefSeq; XP_004780649.1; XM_004780592.3.
DR RefSeq; XP_004780651.1; XM_004780594.3.
DR RefSeq; XP_044928707.1; XM_045072772.1.
DR STRING; 9669.ENSMPUP00000011455; -.
DR Ensembl; ENSMPUT00000011644.1; ENSMPUP00000011455.1; ENSMPUG00000011546.1.
DR GeneID; 101680792; -.
DR KEGG; mpuf:101680792; -.
DR CTD; 23133; -.
DR eggNOG; KOG1633; Eukaryota.
DR GeneTree; ENSGT00940000157847; -.
DR HOGENOM; CLU_003540_2_0_1; -.
DR OMA; DIFHQNI; -.
DR OrthoDB; 2784357at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0071558; F:histone H3K27me2/H3K27me3 demethylase activity; IEA:Ensembl.
DR GO; GO:0051864; F:histone H3K36 demethylase activity; IEA:Ensembl.
DR GO; GO:0032454; F:histone H3K9 demethylase activity; IEA:Ensembl.
DR GO; GO:0035575; F:histone H4K20 demethylase activity; IEA:Ensembl.
DR GO; GO:0005506; F:iron ion binding; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0061188; P:negative regulation of rDNA heterochromatin formation; IEA:Ensembl.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd15642; PHD_PHF8; 1.
DR Gene3D; 1.20.58.1360; -; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR041070; JHD.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR PANTHER; PTHR23123:SF11; HISTONE LYSINE DEMETHYLASE PHF8; 1.
DR PANTHER; PTHR23123; PHD/F-BOX CONTAINING PROTEIN; 1.
DR Pfam; PF17811; JHD; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 5..56
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 195..351
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 479..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 113814 MW; 959E5F807BAE0DDE CRC64;
MASVPVYCLC RLPYDVTRFM IECDMCQDWF HGSCVGVEEE KAADIDLYHC PNCEVLHGPS
IMKKRRVSSK GHDTHKGKPV KTGSPTFIRE LRSRTFDSSD EVILKPTGSQ LTVEFLEENS
FSVPILVLKK DGLGMTLPSP SFTVRDVEHY VGSDKEIDVI DVTRQADCKM KLGDFVKYYY
SGKREKVLNV ISLEFSDTRL SNLVETPKIV RKLSWVENLW PEECIFERPN VQKYCLMSVR
DSYTDFHIDF GGTSVWYHVL KGEKIFYLIR PTNANLTLFE CWSSSSNQNE MFFGDQVDKC
YKCSVKQGQT LFIPTGWIHA VLTPVDCLAF GGNFLHSLNI EMQLKAYEIE KRLSTADLFK
FPNFETICWY VGKHILDIFR GLRENRRHPA SYLVHGGKAL NLAFRAWTRK EALPDHEDEI
PETVRTVQLI KDLAREIRLV EDIFQQNVGK TSNIFGLQRI FPAGSIPLTR PVHSTSVSMS
RLSLPSKSGS KKKGLKPKEL FKKAERKGKE SSALGPAGQL SYNLMDPYNH QALKTGSSQK
AKFNITGTCL NDSDDDSPDL DLDGNEGPLA LLMSNGSTKR VKTLSKSRRA KLTKKADKAR
LVAEQVMEDE FDLDSDDELQ IDERLGKEKA TLIIRPKFPR KLPRAKPCSD PNRVREPGEV
EFDIEEDYTT DEDMVEGVEG KLGNGSGAGG ILDLLKASRQ VGGPDYAALT EAPASPSTQE
AIQGMLCMAN LQSSSSSPAT SSLQAWWTGG QDRSSGSSSS GLGTVSSSPA SQRTPGKRPI
KRPAYWRTES EEEEENASLD EQDSLGACFK DAEYIYPSLE SDDDDPALKS RPKKKKNSDD
APWSPKARVT PTLPKQDRPV REGTRVASIE TGLAAAAAKL AQQELQKAQK KKYIKKKPLP
KEVEQPRPQE SILSVAAPAP TLATTPQLLT SSSPPPPPEP KQEALSGSLV DHEYTARPNA
FGMAQANRST TPMAPGVFLT QRRPSVGSQS NQAGQGKRPK KGLATAKQRL GRILKIHRNG
KLLL
//
