ID M3YK12_MUSPF Unreviewed; 932 AA.
AC M3YK12;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Dual serine/threonine and tyrosine protein kinase {ECO:0000256|ARBA:ARBA00040421};
DE EC=2.7.12.1 {ECO:0000256|ARBA:ARBA00013203};
DE AltName: Full=Dusty protein kinase {ECO:0000256|ARBA:ARBA00042638};
DE AltName: Full=Receptor-interacting serine/threonine-protein kinase 5 {ECO:0000256|ARBA:ARBA00041268};
GN Name=DSTYK {ECO:0000313|Ensembl:ENSMPUP00000011669.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011669.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000011669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000972};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.12.1; Evidence={ECO:0000256|ARBA:ARBA00001076};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001687};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004221}. Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell junction
CC {ECO:0000256|ARBA:ARBA00004282}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}.
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DR EMBL; AEYP01041258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01041259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01041260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01041261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01041262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01041263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YK12; -.
DR STRING; 9669.ENSMPUP00000011669; -.
DR Ensembl; ENSMPUT00000011861.1; ENSMPUP00000011669.1; ENSMPUG00000011763.1.
DR eggNOG; KOG0192; Eukaryota.
DR GeneTree; ENSGT00840000129948; -.
DR HOGENOM; CLU_014116_0_0_1; -.
DR InParanoid; M3YK12; -.
DR OMA; KSCIHLI; -.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR CDD; cd13975; PKc_Dusty; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR46392; DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE; 1.
DR PANTHER; PTHR46392:SF1; DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 655..909
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 398..444
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 684
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 932 AA; 105685 MW; 7915806D1784EF2F CRC64;
MEGDGVPWGS EPVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK FFRDIKCSHS
HSCPSYPSGY CGSKIGPVVC FLLPRPPLPR AGQLSCIAFP PKEEKYLQQV VDCLPCILIL
GQDCNVKCQL LNLLLGVHVL PTTRPAREES CRLRRLRFTY GTQTRVGLAL PGQYELVHTL
VAHQGNWETI PEEDLEVQED GEDTAPVLAE LEVTMHHALL QDVDIVVAPC QGLRPAVDVL
GDLVNDFLPV ITYALHKDEL SERDEQELQE IRKYFSFPVF FFKVPKLGSE IIASPTRRLE
NERSALHHQL VDLGYLSSSH WNCGTSGQDT KAQSMLVEQS EKLRHLSTFS HQVLQTRLVD
TAKALNRVHC HCLDIFINQA FDMQRDLQIT PKRLEYTRKK ENELYESLMN IANRKQEEMK
DMIVETLNAM KEELLEDAAN MEFKDVIVPE NGEAVGTREI KCCIRQIQEL IISRLNQAVA
NKLISSVDYL RESFVGTLER CLQSLEKSQD VSVHITSNYL KQILNAAYHV EVTFHSGSSV
TRMLWEQIKQ IIQRLTWVSP PAITLEWKRK VAQEAIESLS ASKLAKSICS QFRTRLNSSH
EAFAASLRQL EAGHSGRLEK TEDLWLKVRK DHAPRLARLS LESRSLQDVL LHRKPKLGQE
LGRGQYGVVY LCDNWGGHFP CALKSVVPPD EKHWNDLALE FHYMRSLPKH ERLVDLHGSV
IDYSYGGGSS IAVLLIMERL HRDLYTGLKA GLTLETRLQI ALDVVEGVRF LHSQGLVHRD
IKLKNVLLDK QNRAKITDLG FCKPEAMMSG SIVGTPIHMA PELFTGKYDN SVDVYAFGIL
FWYICSGSVK LPEAFERCAS KDHLWNNVRR GARPERLPVF DEECWQLMEA CWDGDPSQRP
LLGIVQPMLQ GIMDRLCKSS SERPSRGLDD ST
//
