UniProt: M3YKY1

Database: UniProt
Entry: M3YKY1_MUSPF

LinkDB:  M3YKY1_MUSPF 
Original site:  M3YKY1_MUSPF

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Ontology (24)   
   GO (24)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (16)   
   InterPro (10)   
   Pfam (3)   
   PROSITE (1)   
   SMART (2)   
All databases (48)   

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ID   M3YKY1_MUSPF            Unreviewed;       739 AA.
AC   M3YKY1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Vascular cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSMPUP00000011988.1};
DE   SubName: Full=Vascular cell adhesion protein 1 {ECO:0000313|RefSeq:XP_004775232.1};
GN   Name=VCAM1 {ECO:0000313|Ensembl:ENSMPUP00000011988.1,
GN   ECO:0000313|RefSeq:XP_004775232.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000011988.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000011988.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004775232.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004775232.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR   EMBL; AEYP01085876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01085877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004775232.1; XM_004775175.3.
DR   STRING; 9669.ENSMPUP00000011988; -.
DR   Ensembl; ENSMPUT00000012183.1; ENSMPUP00000011988.1; ENSMPUG00000012080.1.
DR   GeneID; 101683254; -.
DR   KEGG; mpuf:101683254; -.
DR   CTD; 7412; -.
DR   eggNOG; ENOG502QSKQ; Eukaryota.
DR   GeneTree; ENSGT00940000156511; -.
DR   HOGENOM; CLU_022321_0_0_1; -.
DR   OMA; TYVCEGV; -.
DR   OrthoDB; 5359770at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0071065; C:alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex; IEA:Ensembl.
DR   GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR   GO; GO:0002102; C:podosome; IEA:Ensembl.
DR   GO; GO:0098631; F:cell adhesion mediator activity; IEA:Ensembl.
DR   GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR   GO; GO:0008131; F:primary amine oxidase activity; IEA:Ensembl.
DR   GO; GO:0009308; P:amine metabolic process; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0140039; P:cell-cell adhesion in response to extracellular stimulus; IEA:Ensembl.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR   GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
DR   GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:Ensembl.
DR   GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0050901; P:leukocyte tethering or rolling; IEA:Ensembl.
DR   GO; GO:0022614; P:membrane to membrane docking; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR   CDD; cd00096; Ig; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR   InterPro; IPR047012; ICAM_VCAM.
DR   InterPro; IPR003987; ICAM_VCAM_N.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008424; Ig_C2-set.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR003989; VCAM-1.
DR   PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR   PANTHER; PTHR13771:SF14; VASCULAR CELL ADHESION PROTEIN 1; 1.
DR   Pfam; PF05790; C2-set; 2.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF13927; Ig_3; 3.
DR   PRINTS; PR01472; ICAMVCAM1.
DR   PRINTS; PR01474; VCAM1.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 5.
DR   SUPFAM; SSF48726; Immunoglobulin; 7.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   4: Predicted;
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..739
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5041118199"
FT   TRANSMEM        700..720
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          40..105
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          223..309
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          312..397
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          511..595
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          600..684
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   739 AA;  81519 MW;  3A0F7205C46D43EB CRC64;
     MPGKMVVIFG ASNVLWMVFT VSQAFKMEIF PEHRVIAQIG DVISLTCRTT GCEPPSFSWR
     TQIDSPLNGK VRNEGNNSTL TMDPVSFNNE HAYVCTATCG SKKLEKGIQV EIYSFPKDPE
     IHLSGPLELG KPVTVTCMVP DVYPFDRLEV NLMKDNKLLK NQEFLEPMER KSLETKSLVV
     TFIPTNEDIG KALVCQAKLN IDEFDFEPKE RETTKKLQVY ISPKNTVISV SPSTKLQEGG
     SVTMTCSSEG FPAPQIFWSK KLDNGNVQLL SGNATLTLIA MRIEDSGIYV CEGVNQVGKD
     GKEVELIVQE KPFIVEISPG PQVIAQIGDS VVLTCGVTGC ESPSFSWRTQ IDSPLSGQVK
     TEGSKSTLTL SPVSFENEHS YLCTVTCGRK KLEKRISVDL YSFPRDPEIE MSGLLVSGNP
     VTVSCEVPNV YPSDRLEIEL FKGESVIESK TFLEDMDRKS LETKSLDMTF IPTTEDTGKV
     LVCLAQLRVG EMEFEPKQRQ STRMLHVNVA PRDTTILVSP SSILEEGSSV NMTCSSNGLP
     APKILWSRQL SNGDLQPLSE NSTLTLTSTK MDDSGIYVCE GINQAGISRK EVELIIQVAP
     KDIQLTAFPS ESVKEGDTVI ISCTCGNVPK TWIILKKKAE TGDTVLKSRD GAYTIHKVQL
     EDAGVYECES KNEVGLQLRS LTLDVKGREN NKDYFSPELL VLYCASSLII PAIGMIIYFA
     RRANMKGSYS LVEAQKSKV
//

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