ID M3YL76_MUSPF Unreviewed; 661 AA.
AC M3YL76;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein {ECO:0000256|ARBA:ARBA00040699};
DE AltName: Full=APBB1-interacting protein 1 {ECO:0000256|ARBA:ARBA00042746};
GN Name=APBB1IP {ECO:0000313|Ensembl:ENSMPUP00000012083.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012083.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000012083.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MRL family. {ECO:0000256|ARBA:ARBA00038382}.
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DR EMBL; AEYP01043722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01043725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004757695.1; XM_004757638.2.
DR RefSeq; XP_004757696.1; XM_004757639.2.
DR AlphaFoldDB; M3YL76; -.
DR STRING; 9669.ENSMPUP00000012083; -.
DR Ensembl; ENSMPUT00000012282.1; ENSMPUP00000012083.1; ENSMPUG00000012179.1.
DR GeneID; 101690745; -.
DR KEGG; mpuf:101690745; -.
DR CTD; 54518; -.
DR eggNOG; KOG3751; Eukaryota.
DR GeneTree; ENSGT00940000156105; -.
DR HOGENOM; CLU_023207_2_0_1; -.
DR InParanoid; M3YL76; -.
DR OMA; CCDDQAT; -.
DR OrthoDB; 3144731at2759; -.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0042101; C:T cell receptor complex; IEA:Ensembl.
DR GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0002291; P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; IEA:Ensembl.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16137; RA_MRL_RIAM; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243:SF14; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
FT DOMAIN 176..263
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 314..423
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 82..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..150
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..632
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 72734 MW; 9CB21A2ACD4E7CC1 CRC64;
MGESNEDIDQ MFSNLLGEMD LLTQSLGVDT LPPPDPKLPR AEFNYSVGFK DLNESLNALE
DQDLDALMAD LVADISEAEQ RTIQAQKESS QNQRPPASLE MPDFSGAGAL GYGANVAAVS
VSHYENDLPP PPADPMVDLP PPPPPPKPLS QEEEAAQAKA DKIKLALEKL KEAKVKKLVV
KVHMNDNSTK SLMVDERQLT RDVLDNLFEK THCDCNVDWC LYEIYTELQI ERIFEDHENV
VEVLSDWTRD TENKVLFLEK EEKYAVFKNP QNFYLDNKGK KDGKKDGKET NEKMNAKNKE
SLLEESFCGS SIIVPELEGA LYLKEDGKKS WKRRYFLLRA SGIYYVPKGK TKTSRDLACF
IQFKNVNIYY GIQCKMRYKA PTDYCFVLKH PQIQKESQYI KYLCCDDART LNQWVMGIRI
AKYGKTLFDN YQRAVERAGL ASRWTNLGPA SAAPPSTGLK AGTTQANGQI PQAVHSVSAV
LEEAQRHAET AKDKKPAFGN HDPGAPRAHQ LPKSSLPPPP PVRRSSDVCG SPATVPRAKG
PRGGFPAPPD DSLPPPPPPP PLEDDELPPP PPDFNDGPPD FVPPPPPSFA GEAGSQLPPP
PPPPPAPAPE APKPPPVGVK RPPAPPKRKE NPGPPGGGGS GEQDFMSDLM KALQKKRGNM
S
//
