ID M3YLF8_MUSPF Unreviewed; 162 AA.
AC M3YLF8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Neurotransmitter-gated ion-channel transmembrane domain-containing protein {ECO:0000259|Pfam:PF02932};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012165.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000012165.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell
CC membrane {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01106038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01106039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01106040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01106041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01106042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012906284.1; XM_013050830.1.
DR AlphaFoldDB; M3YLF8; -.
DR STRING; 9669.ENSMPUP00000012165; -.
DR Ensembl; ENSMPUT00000012365.1; ENSMPUP00000012165.1; ENSMPUG00000012262.1.
DR KEGG; mpuf:106003318; -.
DR eggNOG; KOG3642; Eukaryota.
DR GeneTree; ENSGT00940000155607; -.
DR HOGENOM; CLU_135381_0_0_1; -.
DR InParanoid; M3YLF8; -.
DR OMA; NCKEAVM; -.
DR OrthoDB; 4265336at2759; -.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR005440; GABBAg3_rcpt.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF195; GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-3; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR01623; GABAARGAMMA3.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
PE 4: Predicted;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Chloride channel {ECO:0000256|ARBA:ARBA00023173};
KW Ion channel {ECO:0000256|ARBA:ARBA00023173};
KW Ion transport {ECO:0000256|ARBA:ARBA00023173};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023173}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..111
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 162 AA; 18605 MW; 73406A4254038E9F CRC64;
MTIYFELSRR MGYFTIQTYI PCILTVVLSW VSFWIKKDAT PARTALGITT VLTMTTLSTI
ARNSLPRVSY VTAMDLFVTV CFLFVFAALM EYATLNYYSS CRKPTTTKKK TSLLHPDSSR
WIHERISLQA PSVCIAVKVQ IFLRTLTKLR LNDILTVFVC MY
//
