ID M3YLX8_MUSPF Unreviewed; 888 AA.
AC M3YLX8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator {ECO:0000313|Ensembl:ENSMPUP00000012335.1};
GN Name=RALGDS {ECO:0000313|Ensembl:ENSMPUP00000012335.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012335.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000012335.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
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DR EMBL; AEYP01042399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01042400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YLX8; -.
DR STRING; 9669.ENSMPUP00000012335; -.
DR Ensembl; ENSMPUT00000012536.1; ENSMPUP00000012335.1; ENSMPUG00000012429.1.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000153181; -.
DR HOGENOM; CLU_010252_0_1_1; -.
DR InParanoid; M3YLX8; -.
DR OMA; EHFVAWF; -.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17209; RA_RalGDS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR015758; RalGDS_RA.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 57..194
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 360..622
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 772..859
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 200..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..281
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..323
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 888 AA; 96986 MW; 1CBF67E6CDB554B0 CRC64;
MMVDCQSCTQ EIGEELLNGL IFSISLRKVQ AQPGANKGQR WLGCENESAL SLYETCKVRT
VKAGTLEKLV EHLVPAFQGS DLSYVTIFLC TYRAFTTTQQ VLDLLFKRYG RRDALTASSR
YGCILPYSDE DGGPQDQLKN AVSSILGTWL DQYSEDFCQS PDFPCLKQLV AYVQLNMPGS
DLERRAHLLL AQLERAEPAQ AEPEALYPAP APAPVPETAS ELEPALAPTL LPTPEPDAAP
ARTPEPDAAP APALEPDVAP APAPAPTPEP DVAPAPTLEP DAAPAPALEA DVAPAPAPEP
DAAPAPAPEP DAAPAPAPEP EPSLSQTLEP EAAPSPEPPW PSAVAAENGL NEKPHLLAFP
PDLVAEQFTL MDAELFKKVV PYHCLGSIWS QRDKKGKEHL APTVRATVTQ FNSVANCVIT
TCLADRSVTA RGRARVVEHW IEVARECRVL KNFSSLYAIL SALQSNSIHR LKKTWEEVSR
ESFRIFQKLS EIFSDENNYS LSRELLIKEG TSKFATLEMN PKRAQKRPKE TGVIQGTVPY
LGTFLTDLVM LDTAMKDYLY GRLINFEKRR KEFEVIAQIK LLQSACNSYS IVPEEHFRAW
FRAMERLSET ESYNLSCELE PPSESASNTL KAKKNAAIVK RWSDRQAPSG ELSTSGSSHS
KSCDQLRCGP YLSSGDIADA LSVHSAGSSS SDVEEINMSF VPESPDGQEK KFWESTSQSS
PETSGISSAS SSTSSSSAST TPVAATRTHK RSMSGVCGCS SSLPLYNQQV GDCCIIRVSL
DVDNGNMYKS ILVTSQEKAP AVIRKAMDKH NLDEDEPDDY ELVQVISDDR KLKIPDNANV
FYAMNSTANY DFVLKKRTFT KGAKVRHGTS STLPRMKQKG LKIAKGIF
//
