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Database: UniProt
Entry: M3YPP1_MUSPF
LinkDB: M3YPP1_MUSPF
Original site: M3YPP1_MUSPF 
ID   M3YPP1_MUSPF            Unreviewed;      2024 AA.
AC   M3YPP1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   31-JAN-2018, entry version 29.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1I {ECO:0000313|Ensembl:ENSMPUP00000013299};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013299, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000013299}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000013299};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000013299}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000013299}.
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DR   EMBL; AEYP01012746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01012747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01012748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01012749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01012750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9669.ENSMPUP00000013299; -.
DR   Ensembl; ENSMPUT00000013511; ENSMPUP00000013299; ENSMPUG00000013398.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3YPP1; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0030431; P:sleep; IEA:Ensembl.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF209; PTHR10037:SF209; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    121    141       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    208    232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    345    366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    372    397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    726    748       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    768    784       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    804    826       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1135   1153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1173   1194       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1206   1232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1270   1292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1371   1395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1451   1468       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1488   1507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1571   1598       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1673   1694       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       78    408       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      604    831       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1133   1405       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1451   1704       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1404   1431       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2024 AA;  225078 MW;  73AB4F0E3D87A503 CRC64;
     MAESSPPPSS SAAAAPAAEP GVTEQPGPQS PPPSPPGLEE PLDGADPEVP HPDLAPVAFF
     CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ PCDDMDCLSD RCKILQVFDD
     FIFVFFAMEM VLKMVALGIF GKKCYLGDTW NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV
     RVLRPLKAIN RVPSMRILVN LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF
     LEENFTIQGD VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV
     YDFGGGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI FQVITLEGWV
     EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ FSETKQREHR LMLEQRQRYL
     SSSTVASYAE PGDCYEEIFQ YVCHILRKAR RRALGLYQAL QSRRQGPAPG APTSIKPGPH
     AKEPRHYKLC PQHSPLDPTP HALVQPISAM LASDPASCPR CQHEASRRPS GLGSTDSGQE
     GSGSGGSGGG SEEADGDGAR SSEDGASSGL GKEDEEERAA GATRLCGDVW RETRAKLRGI
     VDSKYFNRGI MMAILVNTVS MGIEHHEQPE ELTNILEICN VVFTSMFALE MLLKLAAFGL
     FDYLRNPYNI FDSIIVIISI WEIVGQADGG LSVLRTFRLL RVLKLVRFMP ALRRQLVVLM
     KTMDNVATFC MLLMLFIFIF SILGMHIFGC KFSLRTDTGD TVPDRKNFDS LLWAIVTVFQ
     ILTQEDWNVV LYNGMASTSP WASLYFVALM TFGNYVLFNL LVAILVEGFQ AEGDANRSYS
     DEDQSSSNME EFDKLQEGLD GGADPKLCPI PMTPNGHLDP SLPLGGHLGP AGAAAPAPRL
     SLQPDPVLVA LGSRKSSVMS LGRMSYDQRS LSSSRSSYYG PWGRSGAWAS RRSSWNSLKH
     KPLSAEHESL LSAERGGGPR ACEGARDEGP PRAAPPHAPH AHHTHHGPHP AHRHRHHRRT
     LSLDTRDSMD LAELVPTMGA HPRAAWRAVG PAPGHEDCNG RMPSIAKDVF TKMDDRRDRG
     EDEEEIDYTL CFRVRKMIDV YKPNWCEVRE DWSVYLFSPE NRFRVLCQTI IAHKLFDYVV
     LAFIFLNCIT IALERPQIEA GSTERIFLTV SNYIFTAIFV GEMTLKVVSL GLYFGEQAYL
     RSSWNVLDGF LVFVSIIDIV VSVASAGGAK ILGVLRVLRL LRTLRPLRVI SRAPGLKLVV
     ETLISSLKPI GNIVLICCAF FIIFGILGVQ LFKGKFYHCL GVDTRNITNR SDCVAANYRW
     VHHKYNFDNL GQALMSLFVL ASKDGWVNIM YNGLDAVAVD QQPVPNHNPW MLLYFISFLL
     IVSFFVLNMF VGVVVENFHK CRQHQEAEEA RRREEKRLRR LEKKRRKAQR LPYYATYCPT
     RLLIHSMCTS HYLDIFITFI ICLNVVTMSL EHYNQPTSLE TALKYCNYMF TTVFVLEAVL
     KLVAFGLRRF FKDRWNQLDL AIVLLSVMGI TLEEIEINAA LPINPTIIRI MRVLRIARVL
     KLLKMATGMR ALLDTVVQAL PQVGNLGLLF MLLFFIYAAL GVELFGKLVC NDENPCEGMS
     RHATFENFGM AFLTLFQVST GDNWNGIMKD TLRDCTHDER SCLSSLQFVS PLYFVSFVLT
     AQFVLINVVV AVLMKHLDDS NKEAQEDAEM DAELELEMAH GLGPSPRPPA SPPGGPGRGP
     GGEGGGGDAE GRLCPRCYSP AQENLWLDSV SLIIKDSLEG ELTIIDNLSG SIFHHYSSPA
     GCEKCHHDKQ EVQLAETEAF SLNSDKSSSI LLGDDLSLED PTACPLGPKD SRGEPDTPEP
     VHAGEVGECF FPLPNTAVLS DPENFLWERE VVPSNPVRSW LKQESSRAAP PRPFSPDASS
     PLLPMPAEFF HPAVSASQKG QEKGPGTGTL PKIALQGSWA SLRSPSVNCS LLRQATGSDT
     SLEASRSSSA GSLQTTLEDS LTXXXXXXXX XXXXXXXXXX XXXX
//
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