ID M3YTA5_MUSPF Unreviewed; 847 AA.
AC M3YTA5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase 1 {ECO:0000313|Ensembl:ENSMPUP00000014565.1};
GN Name=ENPP1 {ECO:0000313|Ensembl:ENSMPUP00000014565.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000014565.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000014565.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase
CC family. {ECO:0000256|ARBA:ARBA00010594}.
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DR EMBL; AEYP01006898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01006899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YTA5; -.
DR STRING; 9669.ENSMPUP00000014565; -.
DR Ensembl; ENSMPUT00000014798.1; ENSMPUP00000014565.1; ENSMPUG00000014674.1.
DR eggNOG; KOG2645; Eukaryota.
DR GeneTree; ENSGT00940000156034; -.
DR HOGENOM; CLU_012256_0_1_1; -.
DR InParanoid; M3YTA5; -.
DR OMA; PMYPSFQ; -.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0106177; F:cyclic-GMP-AMP hydrolase activity; IEA:Ensembl.
DR GO; GO:0004551; F:dinucleotide phosphatase activity; IEA:Ensembl.
DR GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0047429; F:nucleoside triphosphate diphosphatase activity; IEA:Ensembl.
DR GO; GO:0016791; F:phosphatase activity; IEA:Ensembl.
DR GO; GO:0004528; F:phosphodiesterase I activity; IEA:Ensembl.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; IEA:Ensembl.
DR GO; GO:0046034; P:ATP metabolic process; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0006091; P:generation of precursor metabolites and energy; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0030505; P:inorganic diphosphate transport; IEA:Ensembl.
DR GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:Ensembl.
DR GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0046325; P:negative regulation of glucose import; IEA:Ensembl.
DR GO; GO:0045719; P:negative regulation of glycogen biosynthetic process; IEA:Ensembl.
DR GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0031953; P:negative regulation of protein autophosphorylation; IEA:Ensembl.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:Ensembl.
DR GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:Ensembl.
DR GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR GO; GO:0010035; P:response to inorganic substance; IEA:Ensembl.
DR GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF77; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF01033; Somatomedin_B; 2.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 2.
DR PROSITE; PS50958; SMB_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..847
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004045765"
FT DOMAIN 24..64
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 65..109
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
SQ SEQUENCE 847 AA; 97370 MW; DE64BFB6087F34F7 CRC64;
VLSVCVLTTI LGCIFGLKPS CAKEVKSCKG RCFERTFGNC RCDVACVDLG NCCLDYQETC
IEPERIWTCS KFRCGEKRLS RSLCSCSDDC RDKGDCCINY SAVCRGEKSW VEETCENINE
PECPAGFEMP PTLLFSLDGF RAEYLHTWGG LLPVISKLKN CGTYAKNMRP VYPTKTFPNH
YSIVTGLYPE SHGIIDNKIY DPKINAFFAL KSKEKFNPAW YKGEPIWLTT KYQGLRSGTF
FWPGSDVKIN GILPDIYKIY NGYLPFRWRV YTGITSLSRY KKFRPHFYTL YLEEPDSSGH
SYGPVSSEVI RVLQRVDNMV GMLMDGLKEL NLHRCLNLIL VSDHGMEQGS CKKYVYLNKY
LGDAKDIKIV YGPAARLRPS DVPDKYFSFD YEDLARNLSC REPNQHFKPY LKHFLPKRLH
FAKNDRIEPL TFYLDPKWQL ALAPSEKEHC GNGFHGSDNL FSNMQALFIG YGPGFKHRFE
VDSFENIEVY NLMCDLLNLT PAPNNGTHGS LNHLLKNPVY NPENPREVHP VGQCPFARSP
RRNLECSCHP SVLPVVDFEI QLNLTVAEAQ EKVIKRSTLP YGRPRVLQRN TSVCLLYQHQ
FVSAYSNDIL MPLWTSYTVR RNDSFSAEDF SNCLYQDLRI SLSPVHKCSF YKNNAELSYE
FLYPPQLNKG SDQLYSEALL NTNIVPMYQS FQVIWRYFHG TLLQRYAEER NGVNVVSGPV
FDSDYDGRYD SSETLKQNSR LIRNQEILIP THFFIVLTSC KNTFQTPSQC DELDTLAFIL
PHRTDNSESC VQGKHESSWV EELLKLHRAR ITDVELITGL SFLQERKEPV ADILQLKTRL
PVFDQED
//