GenomeNet

Database: UniProt
Entry: M3YTA5_MUSPF
LinkDB: M3YTA5_MUSPF
Original site: M3YTA5_MUSPF 
ID   M3YTA5_MUSPF            Unreviewed;       847 AA.
AC   M3YTA5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   SubName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase 1 {ECO:0000313|Ensembl:ENSMPUP00000014565.1};
GN   Name=ENPP1 {ECO:0000313|Ensembl:ENSMPUP00000014565.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000014565.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000014565.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase
CC       family. {ECO:0000256|ARBA:ARBA00010594}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AEYP01006898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01006899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3YTA5; -.
DR   STRING; 9669.ENSMPUP00000014565; -.
DR   Ensembl; ENSMPUT00000014798.1; ENSMPUP00000014565.1; ENSMPUG00000014674.1.
DR   eggNOG; KOG2645; Eukaryota.
DR   GeneTree; ENSGT00940000156034; -.
DR   HOGENOM; CLU_012256_0_1_1; -.
DR   InParanoid; M3YTA5; -.
DR   OMA; PMYPSFQ; -.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0106177; F:cyclic-GMP-AMP hydrolase activity; IEA:Ensembl.
DR   GO; GO:0004551; F:dinucleotide phosphatase activity; IEA:Ensembl.
DR   GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0047429; F:nucleoside triphosphate diphosphatase activity; IEA:Ensembl.
DR   GO; GO:0016791; F:phosphatase activity; IEA:Ensembl.
DR   GO; GO:0004528; F:phosphodiesterase I activity; IEA:Ensembl.
DR   GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; IEA:Ensembl.
DR   GO; GO:0046034; P:ATP metabolic process; IEA:Ensembl.
DR   GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR   GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR   GO; GO:0006091; P:generation of precursor metabolites and energy; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0030505; P:inorganic diphosphate transport; IEA:Ensembl.
DR   GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:Ensembl.
DR   GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0046325; P:negative regulation of glucose import; IEA:Ensembl.
DR   GO; GO:0045719; P:negative regulation of glycogen biosynthetic process; IEA:Ensembl.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0031953; P:negative regulation of protein autophosphorylation; IEA:Ensembl.
DR   GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:Ensembl.
DR   GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0010035; P:response to inorganic substance; IEA:Ensembl.
DR   GO; GO:0030730; P:sequestering of triglyceride; IEA:Ensembl.
DR   CDD; cd16018; Enpp; 1.
DR   CDD; cd00091; NUC; 1.
DR   Gene3D; 4.10.410.20; -; 2.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR   InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR   InterPro; IPR020821; Extracellular_endonuc_su_A.
DR   InterPro; IPR044925; His-Me_finger_sf.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   InterPro; IPR020436; SMB_chordata.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR   PANTHER; PTHR10151:SF77; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1; 1.
DR   Pfam; PF01223; Endonuclease_NS; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   Pfam; PF01033; Somatomedin_B; 2.
DR   PRINTS; PR00022; SOMATOMEDINB.
DR   SMART; SM00892; Endonuclease_NS; 1.
DR   SMART; SM00477; NUC; 1.
DR   SMART; SM00201; SO; 2.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR   SUPFAM; SSF90188; Somatomedin B domain; 2.
DR   PROSITE; PS00524; SMB_1; 2.
DR   PROSITE; PS50958; SMB_2; 2.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..847
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004045765"
FT   DOMAIN          24..64
FT                   /note="SMB"
FT                   /evidence="ECO:0000259|PROSITE:PS50958"
FT   DOMAIN          65..109
FT                   /note="SMB"
FT                   /evidence="ECO:0000259|PROSITE:PS50958"
SQ   SEQUENCE   847 AA;  97370 MW;  DE64BFB6087F34F7 CRC64;
     VLSVCVLTTI LGCIFGLKPS CAKEVKSCKG RCFERTFGNC RCDVACVDLG NCCLDYQETC
     IEPERIWTCS KFRCGEKRLS RSLCSCSDDC RDKGDCCINY SAVCRGEKSW VEETCENINE
     PECPAGFEMP PTLLFSLDGF RAEYLHTWGG LLPVISKLKN CGTYAKNMRP VYPTKTFPNH
     YSIVTGLYPE SHGIIDNKIY DPKINAFFAL KSKEKFNPAW YKGEPIWLTT KYQGLRSGTF
     FWPGSDVKIN GILPDIYKIY NGYLPFRWRV YTGITSLSRY KKFRPHFYTL YLEEPDSSGH
     SYGPVSSEVI RVLQRVDNMV GMLMDGLKEL NLHRCLNLIL VSDHGMEQGS CKKYVYLNKY
     LGDAKDIKIV YGPAARLRPS DVPDKYFSFD YEDLARNLSC REPNQHFKPY LKHFLPKRLH
     FAKNDRIEPL TFYLDPKWQL ALAPSEKEHC GNGFHGSDNL FSNMQALFIG YGPGFKHRFE
     VDSFENIEVY NLMCDLLNLT PAPNNGTHGS LNHLLKNPVY NPENPREVHP VGQCPFARSP
     RRNLECSCHP SVLPVVDFEI QLNLTVAEAQ EKVIKRSTLP YGRPRVLQRN TSVCLLYQHQ
     FVSAYSNDIL MPLWTSYTVR RNDSFSAEDF SNCLYQDLRI SLSPVHKCSF YKNNAELSYE
     FLYPPQLNKG SDQLYSEALL NTNIVPMYQS FQVIWRYFHG TLLQRYAEER NGVNVVSGPV
     FDSDYDGRYD SSETLKQNSR LIRNQEILIP THFFIVLTSC KNTFQTPSQC DELDTLAFIL
     PHRTDNSESC VQGKHESSWV EELLKLHRAR ITDVELITGL SFLQERKEPV ADILQLKTRL
     PVFDQED
//
DBGET integrated database retrieval system