ID M3YTH5_MUSPF Unreviewed; 844 AA.
AC M3YTH5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Complement C7 {ECO:0000313|Ensembl:ENSMPUP00000014635.1};
DE SubName: Full=Complement component C7 {ECO:0000313|RefSeq:XP_004738017.1};
GN Name=C7 {ECO:0000313|Ensembl:ENSMPUP00000014635.1,
GN ECO:0000313|RefSeq:XP_004738017.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000014635.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000014635.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004738017.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004738017.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AEYP01001251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01001252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01001253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004738017.1; XM_004737960.3.
DR STRING; 9669.ENSMPUP00000014635; -.
DR Ensembl; ENSMPUT00000014868.1; ENSMPUP00000014635.1; ENSMPUG00000014744.1.
DR GeneID; 101693039; -.
DR KEGG; mpuf:101693039; -.
DR CTD; 730; -.
DR eggNOG; ENOG502QU3G; Eukaryota.
DR GeneTree; ENSGT00940000156804; -.
DR HOGENOM; CLU_014082_0_0_1; -.
DR OMA; LDDGCGD; -.
DR OrthoDB; 5303272at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR048827; C7_FIM2_N.
DR InterPro; IPR048825; C7_KAZAL.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR040729; Kazal_3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF2; COMPLEMENT COMPONENT C7; 1.
DR Pfam; PF21284; C7_FIM2_N; 1.
DR Pfam; PF21330; C7_KAZAL; 1.
DR Pfam; PF18434; Kazal_3; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..844
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041118233"
FT DOMAIN 124..457
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 570..629
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 630..691
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 519..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 91..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 600..627
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 844 AA; 92742 MW; CA8CCD05FC96E09B CRC64;
MKVILLFILV GFIGEFQVFS RAASPVNCQW DSYASWSECN GCTKTQTRRR SVAVYGQYGG
QPCVGSAFET QSCEPTLGCP VEEGCGERFR CFSGQCISKS LVCNGDSDCE EDGADEDRCE
DSQSRPSCDL DEPPPNIELT GNGYNELTGQ FRKTVINTKS FSGQCRKVFS GDGKKFYRLS
GNILSYTFQV KINNDFNYEF YNSTWSYVKN TMTDYTSSSS KSHLFGSSSS GSYHSIPNYN
DNHKKKSYQL LVVQNSVEVA QFINNNPEFL QLAEPFWKEL SFLPSLYDYS AYRRLIDQYG
THYLQSGSLG GEYKVLFYVN SDKIKESGLH SEDMKRCTSS GFNIFFASSS SQKCKTLENA
LKSDSGNKDH VMKGDSFVRG GSPNFVAGLS SLDLNNPAGN KKQYSSWAES VTGSPQVIKQ
KLTPLYELVK EVPCASVKRL YLKRALEEYL DEFDPCHCRP CQNGGIATIK GTQCQCHCKP
YTFGVACEQG VLVGNEAGGV DGGWSCWSSW SSCVQGKKTR SRECNNPPPR EGGKSCIGEP
SESGPCEDEE LQHLRLLEPH CFSLPLTPKE FCPSPPALKD GYVQDEGAKF PVGKNIKYTC
NEGYSLIGDP VARCGDDLRW LVGEMHCQKI ACVLPTLMDG IQSHSRKPFY GVGEKVTISC
SGGMSLEGPS TFLCGSSLKW SPDMKGVRCV KKDAPLPPAV PECQRWEKLK NSRCVCKMPY
ECGSSLDVCA QDERSERILR LTVCKMRVLQ CQGRNYTLAA GDSCTLPAPT EKACGACPLW
GKCDAQSGKC VCREASECED GGFSVCVEVD GVEQTMSECA AGVLRCRGQD VTVTSTQPCA
GGTP
//
