ID M3YX10_MUSPF Unreviewed; 152 AA.
AC M3YX10;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Cyclin dependent kinase inhibitor 2A {ECO:0000313|Ensembl:ENSMPUP00000015870.1};
DE SubName: Full=Cyclin-dependent kinase inhibitor 2A isoform X2 {ECO:0000313|RefSeq:XP_004761861.1};
GN Name=CDKN2A {ECO:0000313|Ensembl:ENSMPUP00000015870.1};
GN Synonyms=LOC101672555 {ECO:0000313|RefSeq:XP_004761861.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000015870.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000015870.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004761861.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004761861.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CDKN2 cyclin-dependent kinase inhibitor
CC family. {ECO:0000256|ARBA:ARBA00038438}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01053748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004761861.1; XM_004761804.3.
DR STRING; 9669.ENSMPUP00000015870; -.
DR Ensembl; ENSMPUT00000016111.1; ENSMPUP00000015870.1; ENSMPUG00000015974.1.
DR GeneID; 101672555; -.
DR KEGG; mpuf:101672555; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000163078; -.
DR HOGENOM; CLU_000134_37_1_1; -.
DR OMA; PNRYGRS; -.
DR OrthoDB; 2321802at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0035985; C:senescence-associated heterochromatin focus; IEA:Ensembl.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0090398; P:cellular senescence; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0042326; P:negative regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0090399; P:replicative senescence; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24201; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24201:SF8; CYCLIN-DEPENDENT KINASE 4 INHIBITOR B; 1.
DR Pfam; PF00023; Ank; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 126..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 152 AA; 15989 MW; 8A783C208DED1226 CRC64;
MEPSADRLAT AAARGRADEV RALLAAGVQP NALNRQGRSP IQVMMMGSTR VAELLLLHGA
DPNCADPVTL TRPVHDAARE GFLDTLVALH RAGARLDVRD AWGRLPVDLA EEQGHHAVAQ
YLGAASGATE GGSHSHSEVA EGPADSQDFK ND
//
