ID   M3YXY8_MUSPF            Unreviewed;       517 AA.
AC   M3YXY8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=ADP-ribosylation factor GTPase-activating protein 3 {ECO:0000256|ARBA:ARBA00039243};
GN   Name=ARFGAP3 {ECO:0000313|Ensembl:ENSMPUP00000016198.1,
GN   ECO:0000313|RefSeq:XP_004771245.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016198.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000016198.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_004771245.1}
RP   IDENTIFICATION.
RC   TISSUE=Brain {ECO:0000313|RefSeq:XP_004771245.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi
CC       apparatus membrane {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004255}.
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DR   EMBL; AEYP01076825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01076826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01076827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004771245.1; XM_004771188.3.
DR   STRING; 9669.ENSMPUP00000016198; -.
DR   Ensembl; ENSMPUT00000016442.1; ENSMPUP00000016198.1; ENSMPUG00000016301.1.
DR   GeneID; 101692027; -.
DR   KEGG; mpuf:101692027; -.
DR   CTD; 26286; -.
DR   eggNOG; KOG0706; Eukaryota.
DR   GeneTree; ENSGT00940000158466; -.
DR   HOGENOM; CLU_023062_6_2_1; -.
DR   OMA; ENGPSKV; -.
DR   OrthoDB; 389572at2759; -.
DR   Proteomes; UP000000715; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:Ensembl.
DR   CDD; cd09028; ArfGap_ArfGap3; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   PANTHER; PTHR45686; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED; 1.
DR   PANTHER; PTHR45686:SF1; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 3; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00288}; Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW   Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00288}.
FT   DOMAIN          10..126
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REGION          180..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   517 AA;  56852 MW;  56D7D3C8C10133C5 CRC64;
     MGDPSKQDIL TIFKRLRSVP TNKVCFDCGA KNPSWASVTY GVFLCIDCSG SHRSLGVHLS
     FIRSTELDSN WSWFQLRCMQ VGGNANASSF FHQHGCATSD TNAKYNSRAA QLYRERIKSL
     ASQATRKHGT DLWLDSCVVP PSTPPPKEED FFASHVSPEA ASGTGWASAQ PEAPLPPRDV
     EITPAHNEGG PEQGPSVEGL NAPTKAGLEV SSIIKKKPNQ AKRGLGAKKG SLGAQKVANT
     CFNEIEKQAR AVDKMKEQED LLARAAPKEE SIVSSLRLAY KDLEIQMKKD EKVNMSGQKK
     TESERLGMGF GNCRSGISHS VTSDMQTIEQ ETPIIAKPRK KYSDDNDDSY FTSSSRYLDE
     PVEFRSSSFS SWEDSSDSYW RKETIKDADA ILKTTGYSDR STARRKPDYE PVGNTDEAQK
     KFGNVKAISS DMYFGRQAQA DYETRARLER LSASSSISSA DLFDEQQKQP AGNYSLANVL
     PTAPDMAQFK QGVRSVAGKL SVFANGVMTS IQDRYGS
//