ID M3YY50_MUSPF Unreviewed; 894 AA.
AC M3YY50;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Scm like with four mbt domains 2 {ECO:0000313|Ensembl:ENSMPUP00000016260.1};
DE SubName: Full=Scm-like with four MBT domains protein 2 isoform X1 {ECO:0000313|RefSeq:XP_004758004.2, ECO:0000313|RefSeq:XP_004758005.2};
GN Name=SFMBT2 {ECO:0000313|Ensembl:ENSMPUP00000016260.1,
GN ECO:0000313|RefSeq:XP_004758004.2, ECO:0000313|RefSeq:XP_004758005.2,
GN ECO:0000313|RefSeq:XP_044928285.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016260.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000016260.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004758004.2, ECO:0000313|RefSeq:XP_004758005.2}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004758004.2,
RC ECO:0000313|RefSeq:XP_004758005.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AEYP01044860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01044864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004758004.2; XM_004757947.3.
DR RefSeq; XP_004758005.2; XM_004757948.3.
DR RefSeq; XP_012914565.1; XM_013059111.1.
DR RefSeq; XP_044928285.1; XM_045072350.1.
DR STRING; 9669.ENSMPUP00000016260; -.
DR Ensembl; ENSMPUT00000016504.1; ENSMPUP00000016260.1; ENSMPUG00000016363.1.
DR KEGG; mpuf:101687439; -.
DR eggNOG; KOG3766; Eukaryota.
DR GeneTree; ENSGT00940000158123; -.
DR HOGENOM; CLU_005352_0_0_1; -.
DR OMA; NMSEPFH; -.
DR OrthoDB; 5405166at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR CDD; cd20112; MBT_SFMBT2_rpt1; 1.
DR CDD; cd20114; MBT_SFMBT2_rpt2; 1.
DR CDD; cd20116; MBT_SFMBT2_rpt3; 1.
DR CDD; cd20118; MBT_SFMBT2_rpt4; 1.
DR CDD; cd09581; SAM_Scm-like-4MBT1_2; 1.
DR Gene3D; 2.30.30.140; -; 4.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047353; MBT_SFMBT2_rpt1.
DR InterPro; IPR047354; MBT_SFMBT2_rpt3.
DR InterPro; IPR047355; MBT_SFMBT2_rpt4.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037604; Scm-like-4MBT1/2_SAM.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF62; SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2; 1.
DR Pfam; PF02820; MBT; 4.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 4.
DR PROSITE; PS51079; MBT; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 44..144
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 152..256
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 266..372
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 380..477
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 821..887
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..702
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..736
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..784
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 100383 MW; 53FB696C351FABF3 CRC64;
MEGSLSASSM QEPASSPPEK QQSSASGHGG LDSEEGSGLE EIGFNWGEYL EETGASAAPH
TSFKHVEISL QSNFQPGMKL EVANKNNPDT YWVATVITTC GQLLLLRYCG YGEDRRADFW
CDVVIADLHP VGWCTQNNKA LMPPDAIKEK YTDWTEFLIR DLTGSRTAPA NLLEGPLRGK
GPIDLITVDS LIELQDSQSP FQYWIVSVIE NVGGRLRLRY VGLEDTESYD QWLFYLDYRL
RPVGWCQENK YRMDPPSEIY PLKMASEWKC ALEKSLADAA QFPLPMEVFK DHADLRSHFF
TVGMKLETVN LSEPFHICPA SVTKVFNNHF FQVTIDDLRA EPSNLSMLCH ADSLGILPVQ
WCLKNGVNLT PPKGYSGQDF DWADYHKQHG TEEAPPFCFR NTTFSRGFTK NMKLEAVNPR
NPGELCVASV VRVKGRLMWL HLEGLQTPSP EFIVDVESMD IFPVGWCEAN SYPLTTPHKT
IAQKKRKIAV VQPEKQLPST VPVEKIPHDL CLFPHLDTAG PVNGKYCCPQ LFINHRCFSG
PYLNKGRIAE LPQSVGPGKC VLVLKEVLSM IINAAYKPGR VLRELQLVED PHWNFQEETL
KAKYRGKTYR AVAKIVRTSD QVADFCRRVC AKLECCPNLF SPVLVSENCP ENCSIHTKTK
YTYYYGKRKK IVKPPIGEAS TESGHPKPAR RRKRRKSIFV QKKRRSSAVD LAVGSGEESE
EEDGDAVDED TGSEETGSEL RDDQTDTSSA EVPSARPRRA VTLRSSSEPE RRPPVERPRR
GRRAQAASCT EGAEQGVATG QDPAEDTKQQ EEERLVLESN PLEWTVTDVV RFIKLTDCAP
LAKIFQEQDI DGQALLLLTL PTVQECMELK LGPAIKLCHQ IERVKVAFYA QYAN
//
