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Database: UniProt
Entry: M3Z273_MUSPF
LinkDB: M3Z273_MUSPF
Original site: M3Z273_MUSPF 
ID   M3Z273_MUSPF            Unreviewed;      4284 AA.
AC   M3Z273;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   30-AUG-2017, entry version 25.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSMPUP00000017685};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSMPUP00000017685};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000017685, ECO:0000313|Proteomes:UP000000715};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000017685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000017685};
RA   Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
RA   Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
RA   Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
RA   Walker B.J., Young S., Birren B., Lindblad-Toh K.;
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMPUP00000017685}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000017685}.
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DR   EMBL; AEYP01088760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01088761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01088762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01088763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01088764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEYP01088765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMPUT00000017945; ENSMPUP00000017685; ENSMPUG00000017796.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000000715; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   PANTHER; PTHR13715:SF97; PTHR13715:SF97; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000715};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      211    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    328       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1358   1571       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1870   1919       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4284 AA;  482972 MW;  E2C55865861EC748 CRC64;
     MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HTHSGMYLSC
     LTTSRSMTDK LAFDVGLQED ATGEACWWTM HPASKQRSEG EKVRVGDDLI LVSVSSERYL
     HLSTASGELQ VDASFMQTLW NMNPICSGCE EGYVTGGHVL RLYHGHMDEC LTISPADSED
     QRRLVHYEGG AVCTHARSLW RLEPLRISWS GSHLRWGQPL RIRHVTTGRY LALTEDQGLV
     VVDASKAHTK ATSFCFRISK EKLDMAPKRD VDGMGPPEIK YGESLCFVQH VASGLWLTYA
     APDPKALRLG VLKKKAMLHQ EGHMDDALSL TRCQQEESQA ARMIYSTAGL YNQFIKGLDS
     FSGKPRGSGP PAGTALPIEG VILSLQDLIG YFEPPSEELQ HEEKQSKLRS LRNRQSLFQE
     EGMLSLVLNC IDRLNVYTTA AHFAEFAGEE AAESWKEIVN LLYELLASLI RGNRTNCALF
     STNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQDL ITENLLPGRE LLLQTNLINY VTSIRPNIFV GRAEGTTQYG
     KWYFEVMVDE VAPFLTAQAT HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWTGHVARPV TSPGQHLLAP EDVVSCCLDL SVPSISFRIN GCPVQGVFEA FNLDGLFFPV
     VSFSAGVKVR FLLGGRHGEF KFLPPPGYAP CHEAVLPRER LHLEPIKEYR REGPRGPHLV
     GPSRCLSHTD FVPCPVDTVQ IVLPPHLERI REKLAENIHE LWALTRIEQG WTYGLVRDDN
     KRLHPCLVDF HSLPEPERNY NLQMSGETLK TLLALGCHVG MADEKAEDNL KKTKLPKTYM
     MSNGYKPAPL DLSHVRLTPA QMTLVDRLAE NGHNVWARDR VAQGWSYSAV QDIPARRNPR
     LVPYRLLDEA TKRSNRDSLC QAVRTLLGYG YNIEPPDQEP SQVESQSRWD RVRIFRAEKS
     YTVQSGRWYF EFEAVTTGEM RVGWARPDLR PDVELGADEL AYVFNGHRGQ RWHLGSEPFG
     RPWQPGDVVG CMIDLTENTI IFTLNGEVLM SDSGSETAFR EIEIGDGFLP VCSLGPGQVG
     HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK SLPQFEAVPL EHPHYEVARV
     DGTVDTPPCL RLSHRTWGSQ NSLVEMLFLR LSLPVQFHQH FRCTAGATPL AHPGLQPPAE
     DEARAAEPDP DYENLRRSAG RWGEAEGGKE GNAKEGAPGG NAQAGLEAQP VRVENEKDAT
     TEKNKKRGFL FKAKKVAMMT QPPATPTLPR LPREVVPADN RDDPEIILNT TTYYYSVRVF
     AGQEPSCVWV GWVTPDYHQH DMNFELSKVR AVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF
     VSSGQQGRIS HTDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP AVFVLPTHQN
     VIQFELGKQK NIMPLSAAMF LSERKNPAPQ CPPRLEVQML MPVSWSRMPN HFLQVETRRA
     GERLGWAVQC QEPLIMMALH IPEENRSMDI LELSERLDLQ RFHSHTLRLY RAVCALGNNR
     VAHALCSHVD QAQLLHALED AHLPGPLRAG YYDLLISIHL ESACRSRRSM LSEYIVPLTE
     ETRAITLFPP GRSAEDGPRR HGLPGVGVTT SLRPPHHFSP PCFVAALPAA GVAEAPARLS
     PSIPLEALRD KALRMLGEAV RDGGQHARDP VGGSVEFQFV PVLKLVSTLL VMGIFADEDV
     KQILKMIEPE VFTEEEEEEE EEEEEEDEEE KEEDEEEEAQ EKEDEEKEEE ETAEGEKEEG
     LEEGLLQMKL PESVKLQMCH LLEYFCDQEL QHRVESLAAF AERYVDKLQA NQRDRYGLLM
     KAFTMSAAET ARRTREFRSP PQEQINMLLH FKDGGDEEEC PLPEEVRQDL LEFHQDLLAH
     CGIQLEGEEE EPEEEATLGS RLMSLLEKVR LVKKKEEKPE EEPPAEESKP QSLQELVSHT
     VVRWAQEDFV QSPELVRAMF SLLHRQYDGL GELLRALPRA YTISPSSVED TMSLLECLGQ
     IRSLLIVQMG PQEENLMIQS IGNIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGGES
     KEIRFPKMVT SCCRFLCYFC RISRQNQRSM FDHLSYLLEN SGIGLGMQGS TPLDVAAASV
     IDNNELALAL QEQDLEKVVS YLAGCGLQSC PMLLAKGYPD IGWNPCGGER YLDFLRFAVF
     VNGESVEENA NVVVRLLIRK PECFGPALRG EGGSGLLAAI EEAIRISEDP ARDGPGVRRD
     RRREHFGEEP PEENRVHLGH AIMSFYAALI DLLGRCAPEM HLIQAGKGEA LRIRAILRSL
     VPLDDLVGII SLPLQIPTLG KDGALVQPKM SASFVPDHKA SMVLFLDRVY GIENQDFLLH
     VLDVGFLPDM RAAASLDTAT FSTTEMALAL NRYLCLAVLP LITKCAPLFA GTEHRAIMVD
     SMLHTVYRLS RGRSLTKAQR DVIEDCLMAL CRYIRPSMLQ HLLRRLVFDV PILNEFAKMP
     LKLLTNHYER CWKYYCLPTG WANFGVTSEE ELHLTRKLFW GIFDSLAHKK YDAELYRMAM
     PCLCAIAGAL PPDYVDASYS SKAEKKATVD AEGNFDPRPV ETLNVIIPEK LDSFINKFAE
     YTHEKWAFDK IQNNWSYGEN IDEELKTHPM LRPYKTFSEK DKEIYRWPIK ESLKAMIAWE
     WTIEKAREGE EEKTEKKKTR KISQSAQTYD PREGYSPQPP DLSGVTLSRE LQAMAEQLAE
     NYHNTWGRKK KQELEAKGGG THPLLVPYDT LTAKEKARDR EKAQELLKFL QMNGYAVTRG
     LKDMELDTSS IEKRFAFGFL QQLLRWMDIS QEFIAHLEAV VSSGRVEKSP HEQEIKFFAK
     ILLPLINQYF TNHCLYFLST PAKVLGSGGH ASNKEKEMIT SLFCKLAALV RHRVSLFGTD
     APAVVNCLHI LARSLDARTV MKSGPEIVKA GLRSFFESAS EDIEKMVENL RLGKVSQART
     QVKGVGQNLT YTTVALLPVL TTLFQHIAQH QFGDDVILDD VQVSCYRTLC SIYSLGTTKN
     TYVEKLRPAL GECLARLAAA MPVAFLEPQL NEYNACSVYT TKSPRERALL GLPNSVEEMC
     PDIPVLERLM ADIGVLAESG ARYTEMPHVI EITLPMLCSY LPRWWERGPE APPPALPAGA
     PPPCTAVTSD HLNSLLGNIL RIIVNNLGID EASWMKRLAV FAQPIVSRAR PELLHSHFIP
     TIGRLRKRAG KVVAEEEQLR LEAKAEAEEG ELLVRDEFSV LCRDLYALYP LLIRYVDNNR
     AHWLTEPNPS AEELFRMVGE IFIYWSKSHN FKREEQNFVV QNEINNMSFL TADNKSKMAK
     SGGSDQERTK KKRRGDRYSV QTSLIVATLK KMLPIGLNMC APTDQELITQ AKNRYALKDT
     DEEVREYLQN NLHLQGKVEG SPSLRWQMAL YRGVPGREED ADDPEKIVRR VQEVSAVLYH
     LEQTEHPYKS KKAVWHKLLS KQRRRAVVAC FRMTPLYNLP THRACNMFLE SYKAGWILTE
     DHSFEDRMID DLSKAGEQEE EEEEVEEKKP DPLHQLVLHF SRTALTEKSK LDEDYLYMAY
     ADIMAKSCHM EEGGENGEAD EEEVEVSFEE KEMEKQRLLY QQARLHNRGA AEMVLQMISA
     CKGETGAMVS STLKLGISIL NGGNADVQQK MLDYLKDKKE VGFFQSIQAL MQTCSVLDLN
     AFERQNKAEG LGMVNEDGTV INRQNGEKVM ADDEFTQDLF RFLQLLCEGH NNDFQNYLRT
     QTGNTTTINI IICTVDYLLR LQESISDFYW YYSGKDVIEE QGKRNFSKAM SVAKQVFNSL
     TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV FAHMMMKLAQ DSSQIELLKE LLDLQKDMVV
     MLLSLLEGNV VNGMIARQMV DMLVESSSNV EMILKFFDMF LKLKDIVGSE AFQDYVTDPR
     GLISKKDFQK AMDSQKQFTG PEIQFLLSCS EADENEMINC EEFANRFQEP ARDIGFNVAV
     LLTNLSEHVP HDPRLRTFLE LAESILEYFR PYLGRIEIMG ASRRIERIYF EISETNRMQW
     EMPQVKESKR QFIFDVVNEG GESEKMELFV SFCEDTIFEM QIAAQISEPE GEPEEDEDDG
     AAXXXXXXXX XXXXXXXXXX XXXX
//
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