ID M3Z276_MUSPF Unreviewed; 500 AA.
AC M3Z276;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Growth differentiation factor 5 {ECO:0000313|Ensembl:ENSMPUP00000017688.1};
DE SubName: Full=Growth/differentiation factor 5 {ECO:0000313|RefSeq:XP_004746610.1};
GN Name=GDF5 {ECO:0000313|Ensembl:ENSMPUP00000017688.1,
GN ECO:0000313|RefSeq:XP_004746610.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000017688.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000017688.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004746610.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004746610.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AEYP01020662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004746610.1; XM_004746553.3.
DR STRING; 9669.ENSMPUP00000017688; -.
DR Ensembl; ENSMPUT00000017948.1; ENSMPUP00000017688.1; ENSMPUG00000017799.1.
DR GeneID; 101692491; -.
DR KEGG; mpuf:101692491; -.
DR CTD; 8200; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000160455; -.
DR HOGENOM; CLU_020515_0_0_1; -.
DR OMA; WHLTWLD; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0060591; P:chondroblast differentiation; IEA:Ensembl.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0035136; P:forelimb morphogenesis; IEA:Ensembl.
DR GO; GO:0035137; P:hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0097152; P:mesenchymal cell apoptotic process; IEA:Ensembl.
DR GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IEA:Ensembl.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
DR CDD; cd19399; TGF_beta_GDF5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF44; GROWTH_DIFFERENTIATION FACTOR 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..500
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041118940"
FT DOMAIN 377..500
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 29..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 500 AA; 55320 MW; 8F5E53E1DC988B4C CRC64;
MRLPKLLTFL LWHLAWLDLE IICTVLGAPD LGQRPQGARP GLAKAEAKER PPLARSIFRP
GGHSYGGGAV ANARAKGGTG QTGGLTQPKK DEPKKLPPRS GGPEPKPGHP PQTRQAATRT
VTPKGQLPGG KAPPKAGSVP SPFLLKKARE TRPPQEPEEP FRPPPITPHE YMLSLYRTLS
DADRKGGNSS VKLEAGLANT ITSFIDKGQD DRGPVVRKQR YVFDISALEK DGLLGAELRI
LRKKPSDTAK PVAPGIGRAA QLKLSSCPSG RQPAALLDVR SVPGLDGSGW EVFDIWKLFR
NFKNSAQLCL ELEAWERGRA VDLRGLGFDR AARQVHEKAL FLVFGRTKKR DLFFNEIKAR
SGQDDKTVYE YLFSQRRKRR APLATRQGKR PSKNPKARCS RKALHVNFKD MGWDDWIIAP
LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS
ANNVVYKQYE DMVVESCGCR
//
