ID M3Z7Y9_MUSPF Unreviewed; 260 AA.
AC M3Z7Y9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=BTB/POZ domain-containing protein KCTD21 {ECO:0000313|RefSeq:XP_004763521.1, ECO:0000313|RefSeq:XP_004763522.1};
DE SubName: Full=Potassium channel tetramerization domain containing 21 {ECO:0000313|Ensembl:ENSMPUP00000019702.1};
GN Name=KCTD21 {ECO:0000313|Ensembl:ENSMPUP00000019702.1,
GN ECO:0000313|RefSeq:XP_004763521.1, ECO:0000313|RefSeq:XP_004763522.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000019702.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000019702.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004763521.1, ECO:0000313|RefSeq:XP_004763522.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004763521.1,
RC ECO:0000313|RefSeq:XP_004763522.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
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DR EMBL; AEYP01058259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004763521.1; XM_004763464.3.
DR RefSeq; XP_004763522.1; XM_004763465.3.
DR STRING; 9669.ENSMPUP00000019702; -.
DR Ensembl; ENSMPUT00000019983.1; ENSMPUP00000019702.1; ENSMPUG00000019831.1.
DR GeneID; 101679019; -.
DR KEGG; mpuf:101679019; -.
DR CTD; 283219; -.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00940000160906; -.
DR HOGENOM; CLU_088122_0_0_1; -.
DR OMA; ANIFCTS; -.
DR OrthoDB; 2912088at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097602; F:cullin family protein binding; IEA:Ensembl.
DR GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd18395; BTB_POZ_KCTD21; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR045763; KCTD11/21_C.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF57; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD21; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF19329; KCTD11_21_C; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 3..72
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 260 AA; 29629 MW; E94BAD422C107C82 CRC64;
MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID RDGKVFRYIL
NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE VELSKAEKNA MLNITLNQRV
QTVHFTVREA PQIYSLSSSS MEVFNANIFS TSCLFLKLLG SKLFYCSNGN LSSITSHLQD
PNHLTLDWVA NVEGLPEEEY TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS
SHPHAVDFMN NKIIRLIRYR
//
