ID M3ZCC2_NOMLE Unreviewed; 433 AA.
AC M3ZCC2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Zinc transporter ZIP6 {ECO:0000256|ARBA:ARBA00039393};
DE AltName: Full=Solute carrier family 39 member 6 {ECO:0000256|ARBA:ARBA00042779};
DE AltName: Full=Zrt- and Irt-like protein 6 {ECO:0000256|ARBA:ARBA00041704};
GN Name=SLC39A6 {ECO:0000313|Ensembl:ENSNLEP00000024359.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024359.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000024359.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000024359.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; ADFV01006587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01006588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01006589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012361772.1; XM_012506318.1.
DR AlphaFoldDB; M3ZCC2; -.
DR Ensembl; ENSNLET00000032720.2; ENSNLEP00000024359.2; ENSNLEG00000006218.3.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000156387; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF22; ZINC TRANSPORTER ZIP6; 1.
DR Pfam; PF02535; Zip; 2.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022906};
KW Zinc {ECO:0000256|ARBA:ARBA00022906};
KW Zinc transport {ECO:0000256|ARBA:ARBA00022906}.
FT TRANSMEM 48..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 176..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 433 AA; 48605 MW; A7EA90842025ADF5 CRC64;
MGIQVPLNAT EFNYLCPAII NQIDARSCLI HTSEKKAEIP PKTYSLQIAW VGGFIAISII
SFLSLLGVIL VPLMNRVFFK FLLSFLVALA VGTLSGDAFL HLLPHSHASH HHSHSHEEPA
MEMKRGPLFS HLSSQNIEES AYFDSTWKGL TALGGLYFMF LVEHVLTLIK QFKDKKKKNQ
KKPENDDDVE IKKQLSKYES QLSTNEEKVD TDDRTEGYLQ ADSQEPSHFD SQQPAILEEE
EVMIAHAHPQ EVYNEYVPRG CKNKCHSHFH DTLGQSDDLI HHHHDYHHIL HHHHHQNHHP
HSHSQRYSRE ELKDAGIATL AWMVIMGDGL HNFSDGLAIG AAFTEGLSSG LSTSVAVFCH
ELPHELGDFA VLLKAGMTVK QAVLYNALSA MLAYLGMATG IFIGHYAENV SMWIFALTAG
LFMYVALVDM VSF
//
