ID M3ZCZ8_XIPMA Unreviewed; 2200 AA.
AC M3ZCZ8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000256|ARBA:ARBA00014590};
GN Name=ASCC3 {ECO:0000313|Ensembl:ENSXMAP00000000090.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000090.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000000090.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000090.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|ARBA:ARBA00008708}.
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DR STRING; 8083.ENSXMAP00000000090; -.
DR Ensembl; ENSXMAT00000000090.2; ENSXMAP00000000090.2; ENSXMAG00000000071.2.
DR eggNOG; KOG0952; Eukaryota.
DR GeneTree; ENSGT00940000155377; -.
DR HOGENOM; CLU_000335_2_1_1; -.
DR InParanoid; M3ZCZ8; -.
DR OMA; MCSATEF; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18022; DEXHc_ASCC3_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 488..672
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 699..921
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1339..1514
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1547..1742
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 208..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2200 AA; 250622 MW; 830C72B841325D25 CRC64;
MSPPRLTGAL RSFSNVSKRE DPTEQLYDLK AKRVKRQELF AREGLTWQKI VHFCSEHQDK
AKRQAASQEL KSLIQAAKQI VGTEHGQEAI ECAAVFLFET FQNKDHVGTE ETCAIKQMFG
PFPSSAVEAS CACVARLVAP LDDSKVEDFI KTQRSRYHHQ RGSAFGCNVN FSYDFYTLDP
LEDLQGSDLG DERVDVDFVN FLNNQQSGYK SASEDDVPHS GTTLSSGDGS ILRREVEKYL
EGGNMISSNP EELCTSLFEM LTSHRSDDEL QNELFELLGP EGLEMISTLL QSRTAIVDSF
LSIPNEKTGY LPDVSRKVSG EMTKPAYGCQ VIIQSEKEKQ MMKIYRREEK KEKKRAKGSD
DGDFSEAVMT FDPKEMRAQR EHVLLNARYE PLLTRERVYE RIRYPNVYDS YAEATKAPAF
VGGARLLLPE GIHRENNKIY EEVEIPYNEP MPVGFEERPV YISELDEVGQ LVFKGMKRLN
RIQSLVFETA YNTNENLLIC APTGAGKTNI AMLTVLHEIR QHIQPGGIIK KDEFKIVYVA
PMKALAAEMT NYFSKRLEPL GIIVKELTGD MQLTKGEILR TQMLVTTPEK WDVVTRKSVG
DVALSQIVRL LILDEVHLLH EDRGPVLESL VARTIRQVES TQSMIRILGL SATLPNYLDV
AAFLHVNPYI GLFFFDSRFR PVPLGQTFVG IKTTNKIQQI HDMEEVCYNK VLQQIKAGHQ
VMVFVHARNA TVRTAFGLIE MAKNRGEICF FQPDQGPDYG QCEKQIQHSR NKQMKEMFPE
GFGIHHAGML RSDRSLMENS FSKGHLKVLI CTATLAWGVN LPAHAVIIKG TQIYDAKRGA
FVDLGILDVM QIFGRAGRPQ FDKYGEGTII TTHDKLSHYL TLLTQQNPIE SQFLGSLADN
LNAEIALGTV TNVEEAVKWL SYTYLYVRMR ANPLVYGINH KTFQMDPALE LHRKELVVES
GRKLDKARMI RFDERTCYFA STDLGRTASH FYIRYNTIET FNELFNSQKT EADILSIVSK
AEEFDQLKVR DEELEELDQL LQNHCILSAA GGVENGYGKV NILLQTYIGR GEVDSFSLVS
DLSYVAQNAA RIVRALFEIA LRKRWPAMTY RLLNLCKVID RRLWGFSHPL RQFPNLSHVI
LNRLEEKRLT VDKLKEMKKD EIGHMLHHVN IGLTVKQCVH QIPAFTMEAS VQPITRTVLR
VRLIITPDFR WNDQVHGSVG EPWWLWVEDP INDHIYHSEY FLLQKKQVVT KESQHIVFTI
PIFEPLPSQY YIKAVSDRWL GAEAVCIINF QNLILPERHP PHTELLDLQP LPVTALGNQE
FESLYTFTHF NPIQTQIFHT LYHTDTNVLL GAPTGSGKTI AAELAMFRVF SKYPSSKVVY
IAPLKALVRE RIEDWKIRIE EKLGKKVVEL TGDVTPDMRA IAQADLIVTT PEKWDGVSRS
WQNRSYVQKV AILIIDEIHL LGEDRGPVLE VIVSRTNFIS SHTAKGVRVV GLSTALANAR
DLADWLGIQQ VGLFNFRPSV RPVPLEVHIH GFPGQHYCPR MASMNKPTFQ AIRSHSPAKP
VLIFVSSRRQ TRLTALDLIA YLATEDNPKQ WLHQDERMIE DVIATVRDSN LKLTLAFGIG
MHHAGLHERD RKTVEELFVN CKIQVLIATS TLAWGVNFPA HLVVVKGTEY YDGKSRRYVD
YPITDVLQMM GRAGRPQFDD QGKAVILVHD IKKDFYKKFL YEPFPVESSL LSVLSDHLNA
EIAAGTISSK QDAMDYITWT YFFRRLVMNP SYYNLEDIGH ESINKYLSNL VERSLLDLEC
SYCIDIKEDD QTVEPLTYGR IASYYYLKHP TIRMFKERLR AELPLHDLLS VLTDAEEYAE
LPVRHNEDQL NSQLAQQLPL QVNPRSFDSA HTKTHLLLQA HFSHTQLLCS DYTTDTKTVL
DNAIRICQAM LDVAANEGWL GTVLSICNLI QMIVQGRWLH DSSLLTLPHV QRHHLYLFRK
WAGIKGKSDA EGFCGPIEGL PELIAACGGK ESVLSAIVNQ EFQPNQILQA WSFLSHLPVL
EVQMSVKGWW EESQEQMECP LPRRGTNLRE ESRWLDVHAD QEYVLQVSLH RLNLGQHRRK
QESKAQAPRF PKAKDEGWFL IMGEVDRKEL LAVKRVGYIR NHTAVSVAFY TPEKTGKCIY
TLYVMSDSYL GLDQQYDIHL NVTPTSIAAQ VNTEVVDSLS
//
