ID   M3ZD29_XIPMA            Unreviewed;      1643 AA.
AC   M3ZD29;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Lactase {ECO:0000313|Ensembl:ENSXMAP00000000121.2};
GN   Name=LCT {ECO:0000313|Ensembl:ENSXMAP00000000121.2};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000121.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000000121.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000121.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   Ensembl; ENSXMAT00000000121.2; ENSXMAP00000000121.2; ENSXMAG00000000123.2.
DR   eggNOG; KOG0626; Eukaryota.
DR   GeneTree; ENSGT00940000155324; -.
DR   HOGENOM; CLU_001859_5_1_1; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 3.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR018120; Glyco_hydro_1_AS.
DR   InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF38; LACTASE_PHLORIZIN HYDROLASE; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 3.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 3.
DR   PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 1.
DR   PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 2.
PE   4: Predicted;
KW   Glycosidase {ECO:0000256|RuleBase:RU004468};
KW   Hydrolase {ECO:0000256|RuleBase:RU004468};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1618..1637
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        1479
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ   SEQUENCE   1643 AA;  186413 MW;  9D0750FAAC19304A CRC64;
     MDFLSVNLEY NCASSKSFAQ ELRSLQTSAG NLPILLYKMP VRDCILSEHQ LLGDLLQVLW
     RNSLNIMGCD MKNVLDGLDM HDSPVRTEVR KSYENIFQKF GDQASDDDLF LTKGFLPGFQ
     WATSSESFKV EGGWLEGGKG ETIWDQFGHE GQAFANHTAD LACDSYNKVD IDVYLLQSLG
     VNTYQFSISW ARIFPSGHKD SLSEEGALYY DNLIDALIES GIQPVATLYH WDLPQALQDD
     GGWTNPSIVA AYKDYAAFCF HRYGNRVKSW NTFSSPWVVS HAGYGTGVHA PGIKDYVTAS
     YQVTHNIVKS HAEAWHVYND NYRTTQGGKV GIALNSDWAE PADVDKPEDK EAAERYLQFM
     LGWFAHPIFI DGDYPEVLKT QIEKKRNECP SSAPAVLPTF TDEEKSRIKG TSDFFGLNHY
     TSRLVSSSVG GCTPGPEGVG DFQAKVDPSW PATASDWIYS MPTGLRSLLN YIKTKYLAIN
     NLPIYITGNG MPTDDIFNDT SRIEYMGGYI SEALKAIELD KVDVQRFTVQ SLMDGFEGNK
     GYSERFGLHH VNFVDSYRPR TPKQSAYFFA QIIEQNGFVL HKQDHFEGVK ISPPRRSTPL
     PPSEVPSASK SVWEKFTPQK KFDRQMYHYG NFSQDFLWGV SSSAYQIEGG WNADGKGPSV
     WDTFTQKPGS GIPADADGNE ACDSYNRLDE DLYMLQALKV KTYRFSLSWS RIFPNGRRES
     LNQKGVDYYN RLINGLLARK ITPMVTIYHW DLPQALQDIG GWQNVEMINI FNDYCDFCFA
     TFGDRVKFWM TMNDPQGLAW LGYGTGQIPP NIKEPGTAPY QVAHNLIKAH ATAYHTYDNK
     YRASQRGMVS IALNAEWVEP KDINVPRDLV AADRAMQFNL GWFAHPIFKN GDYPEAMKAQ
     VLVKSELQGL SQSRLPSFTE EEKNSIKGTA DMFCVNHYTT RIVTHITGLL SPHSYQNDWD
     FTEEQESDSP ATAIKNQRAV SWGLRRLLNW IMEEYGDPEI YITDNGGATT AKTTWDDIDR
     VFFYKTYINE ALKAYELDGV MLKGYTARSL MDSFEWLNGY TVGYGFYHVD FTDPNKPRTP
     KLSAHFYFQL MKDNGFPITE DEKMLYGEFP QGFLWSSATA AYQIEGGWRA DGKSLSIWDK
     FAHTPLKIFN SDNGDIACDS YNKIDEDIAI LKQLGVNHYR FSISWTRVLP DGTTNHINEV
     GFRYYDRLVN ALLAANIQPH ITLYHWDLPQ ALQNVGGWEN DTIVQRFRDY ADVMFSRLGD
     RVKLWVTINE PYNVAMIGHG YGVAAPGISF RPGTLPYIVA HNLIKAHAEA WHLYNDKYRG
     RQNGKVSITI NSDWSEPRNP YKQEDIDAAR RIMQFYIGWF AHPIFNGDYS EMMKTIIRER
     SLAAGLTKSR LPEFTPEEIK RIKGTHDYFG FNHYTTVLAF PVDYGNLQHY DADRGAGTYV
     DRTWLDSGSG WLKVTPFGLR RILNFIKEEY GNPTIIITEN GVSERGPTDL KDSHRSYYYE
     KYINQVLKAY RLDNVDVRGY TAWSLMDNLE WATGFSERFG LFYVNRSDPN VPRVAKESVS
     FFSTIINCNG FPDPASGPHD CLKPKPEATS APENDNSVNF LGLRLSPEEA ETGLNTTFAL
     LLVAATGAIC LSIGCFFTKR RSK
//