ID   M3ZEN3_XIPMA            Unreviewed;       939 AA.
AC   M3ZEN3;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=VPS50 subunit of EARP/GARPII complex {ECO:0000313|Ensembl:ENSXMAP00000000675.2};
GN   Name=VPS50 {ECO:0000313|Ensembl:ENSXMAP00000000675.2};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000675.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000000675.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000675.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; M3ZEN3; -.
DR   Ensembl; ENSXMAT00000000677.2; ENSXMAP00000000675.2; ENSXMAG00000000669.2.
DR   eggNOG; KOG2939; Eukaryota.
DR   GeneTree; ENSGT00390000003442; -.
DR   HOGENOM; CLU_009513_4_0_1; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:1990745; C:EARP complex; IEA:InterPro.
DR   GO; GO:0032456; P:endocytic recycling; IEA:InterPro.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR   InterPro; IPR019514; Syndetin_C.
DR   InterPro; IPR040047; VPS50.
DR   InterPro; IPR019515; VPS54_N.
DR   PANTHER; PTHR13258:SF0; SYNDETIN; 1.
DR   PANTHER; PTHR13258; UNCHARACTERIZED; 1.
DR   Pfam; PF10474; Syndetin_C; 1.
DR   Pfam; PF10475; Vps54_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          43..316
FT                   /note="Vacuolar protein sorting-associated protein 54 N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10475"
FT   DOMAIN          698..932
FT                   /note="Syndetin C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10474"
FT   REGION          321..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   939 AA;  108564 MW;  BBB83902EA957F27 CRC64;
     KRGAGGLMEK DGLFRVPVWG FSLEELRELR QQPIDPQAEQ EIIDSIEEVY FSNDSFDMVR
     HELEKLPPEL NLQELEEYRD KLKRQQAAVK SNDNFLNIIL FSQELERVTA LQTNLQLAAV
     ICTNARRQLK VSKEEFTEAS LGLLANQRRR QLLTGLLKSL RTIKTLQRTD VRLSEMLEEE
     DYPGAIQLCL ECQKAASTFK HYSCIRYSMS RLMWTCKHFD VLHYTKVQKA YTLLGKTQTA
     MDQLHMHFTQ AIHNTVFQVV LGYVELCAGN ADTKFQKMQY KDLCTHITLD SYIPCLTDLC
     KALWEVMLSY HRTMQWHEEH DKQKAVSSQG SNDAAGEPDE LTVDRSYVKK KLEHGLTRIW
     QDVQLKVKVY ILGTDMSNFK YDDFIVVLDV ISRLMQVGEE FCGSKSEVLQ ESIKRQSVNY
     FKNYHRARLE ELRMFLENET WELCPVKSNF NIAQLHEFKF MGQCRSPSVS PSRQAASSAG
     PALEELSLFQ QYHQDGNPFE MHIEHKEEET EDVLASNGYE SDELEKSVYQ DYDSDSDVPD
     ELKQDYVDEQ TGDAPLKSVS RETIRSKKKS DYNLSKASAP ILTNTTLNVI RLVGKYMQMM
     NILKPIAFDV IHCVSQLFDY YLYAVYTFFG RNDMYESSGL GLISSRLRTT LNRIQESLID
     MDPVGENAGV HGPPEDRKEK VPSPHLSQMV ILTDSGTLYG LAQRVVATES LVFLAEQFES
     LQSHLDTMMP AAKKPFLQQF YSQTVSTASE LRKPIYWIVA AKAIDYEQML LMMAGVKWDI
     KEIMSQHNVY VDVLLKEFEQ FNKRLGDVSR HVRIPLPVSN VLWEHCIRLA NRTLVEGYAN
     VKKCSNEGRA LMQLDFQQFL MKLEKLTDLR PIPDKEFVET YIKAYYLTEN DMEQFIKNHR
     EYSMKQLANL VNVCLGSHIN KKARQKLLAA IDDIDRPKR
//