ID M3ZG38_XIPMA Unreviewed; 827 AA.
AC M3ZG38;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Junctophilin 2 {ECO:0000313|Ensembl:ENSXMAP00000001180.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001180.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000001180.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001180.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004163}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the junctophilin family.
CC {ECO:0000256|ARBA:ARBA00008599}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; M3ZG38; -.
DR STRING; 8083.ENSXMAP00000001180; -.
DR Ensembl; ENSXMAT00000001183.2; ENSXMAP00000001180.2; ENSXMAG00000001194.2.
DR eggNOG; KOG0231; Eukaryota.
DR GeneTree; ENSGT00940000159411; -.
DR HOGENOM; CLU_008078_1_0_1; -.
DR InParanoid; M3ZG38; -.
DR OMA; QGSDMEI; -.
DR OrthoDB; 5393283at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030314; C:junctional membrane complex; IEA:InterPro.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR InterPro; IPR017191; Junctophilin.
DR InterPro; IPR003409; MORN.
DR PANTHER; PTHR23085; GH28348P; 1.
DR PANTHER; PTHR23085:SF26; JUNCTOPHILIN-2; 1.
DR Pfam; PF02493; MORN; 8.
DR PIRSF; PIRSF037387; Junctophilin; 3.
DR SMART; SM00698; MORN; 6.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 805..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 256..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..763
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 88406 MW; D04D7ED76FC92503 CRC64;
MSGGRFEFDD GGAYCGGWEG GKAHGHGICT GPKGQGEYSG SWNYGFEVVG VYTWPSGNTY
EGYWSQGKRH GLGVETKGHW IYRGEWTHGF KGRYGVRVSV GSGAKYEGTW NNGLQDGYGT
ETYADGGTYQ GQFTGGMRHG YGVRQSVPYG MAAVVRSPLR TSLTSLRSEH SNGTVLQQDV
PVITTTNASG EETPVATPTQ LGPSRGGFAL TLQVDPEAVK PKKKGLFRRG SLLGKLKKSE
SSTSLSSQKS KISFLRTESA LSSNASDTNS TISGDESLAG AEDFPPVEAD IDATTTEVYM
GEWKNDKRSG YGISERSSGL KYEGEWLNNQ RHGYGCTTFA EGGKEEGKYM NNMLVKAMKK
RVIQLKGTKI KQKVERAVEG AQRAAAIAKQ KAEIAASRTS HAKGKSDGAE QAAQASNSES
SIARLVAKEL SPSFYQPGPE YLKKRVLLEA VEDQENPDTE IHEPLLAEEE PLLADEEPLP
TPPESPILNE LASLMPGSSP ARTPSPSPAI INKEDPKLLG PKGRNEDKSM KGSSTKGSLK
PSSAPGSRAT TPSVSAAAPA SAAPEEGAAS SSRQPSRSPS RLSNKIEQGS DLEIKPLQKF
DSEVKPADVP PVTDAPEMNS LISPDEEEEE APLPSASVPP KAVTPEPKAP EVKTERAPSV
HERPPSTSEK KRPSREGSRP GSRAETRPLP KRQQSPAPPP KRQPSPAPSP KRQQSPAPPP
KRQPSPAPSP KRQLSPSPSP KRQPSPSPSP KRQPSPAPPP KAAANHEPKT VSKPAEPKAI
IAKPLVKSLM TRKMAESSDL EGPNTIMVCM VILLNIGLAI LFVHILS
//
