ID M3ZGB1_XIPMA Unreviewed; 1982 AA.
AC M3ZGB1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Plexin-B1-like {ECO:0000313|Ensembl:ENSXMAP00000001253.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001253.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000001253.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001253.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR Ensembl; ENSXMAT00000001256.2; ENSXMAP00000001253.2; ENSXMAG00000001131.2.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd12793; RasGAP_plexin_B1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF59; PLEXIN-B1 ISOFORM X1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1336..1356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..430
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 621..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..641
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1982 AA; 219064 MW; EEB15FFE0B0A3B93 CRC64;
MPGSLLFVCS SVIPCLVPNN FILFQHLVLH PKPGVGTVYL GARNHLFQLD GSDGLLLEQE
ETTGPVIDSK DCLPPVTKSN CPHADRTDNH NKLLLVDPKA LELITCGSVH QGTCQKRSLA
SIKEVLFSTD KPVDTQYVAA NDPLVSTIGL VVPIPGGNRT VMYVGRGYTA SHPPISTRHL
SSLPAFSYEE TAKLAIAGRL SEYDHNFITA FTRRSYVYFL FYRRDIKSAT RDYQTYVARV
CLEDTSYYSY VEIPLVSVVL FASLACEDLL ALCVFPLDEV DRHIDSTRDL CYTRDGLVEN
QDEVAYIEYE VKSSCANLPP NTLKAYPCGS DHTPSPMASK VPLEAKAVWQ TSAARLTAVA
VSVREGHSIA FLGDAKGNLH KVYLGRDGAV EVYANSTIQP NSPINSDLLL DDRGSHIYIM
TKTTVKKRPV AECGDHLDCQ SCLSARDPYC GWCVLEGQCG QRWECQRGSL QGQWLWSFNQ
TQQCLGIQRL SLYNISLGEK ADIALSVEGL PSLQQDEAYS CFFQDTESPA LLTTTGVICS
TPGASNLPPI GLGDEFVTVT LALRFINVTV AETEFTFYNC SLVQELSGCQ GCVSSRWGCN
WCIHEHVCTH KHTCSQGLTP QLPTVPPPTR TPTPSPPSVP TAPATTATTS TPTTQPAPTE
TSATTKAAVP TVTITGTPPT GPNAESSTPA TRSTTSPFVR LSTQASSTLA DIDTTDGALS
NTEGATKEAI SSLSGSLEDE DTLNVTAEAR PTSPSGTGGQ TDRSAGQMLE ILTFSDLCDQ
ECPCVEKVQD SSLLPVNVER KITLVGQHLD LFQDKDLEYE CVLDVENQSV VVEASVEPDA
DRPSVFFITC QPHQVSNKHF LRLGVMMRRK NNFLIDSAED LHVTLFNCSV GRSDCSRCRT
AEPKYDCVWC GGDASSSCVY RDSCADAIEH TCPAPVIHRL DPESGPTEGG TVVTISGSNL
GQRAEDIQSS VIVAGVPCIV IQSRYEVSSR IVCETTSSGR ETRGHASVSV RGGGHGISAH
TFSFQNPVLS SISPLRGPKA GGSSLTIKGR RLRTGHPREV GVLIGGVPCS NRTGEHGITV
RFGGAERHLQ GFMYHYTPNP NITRAAPSKS FLGGGRIIRV DGHNLDLVQE PKIRVTLRQT
QRGPLRRWRR IVPEANCPDG TLCHVKHHES HCKVHNATLI LCPTPAVGPE ATEARVKVHF
LLDSLHFDFS TVGGETFSYE PNPKLFKLNR NDPSKPFHHK PGSVISVEGE NLDLAMYKQE
VEAWIGGDQC VMKTLSHNHL YCEPPATQPS ITANRKQDSL ESLPEFIVKM GNLNFPLGRV
KYDIQAQSTF PLEAQVGVGV GASVVALIVV IIVLIYRRKS KQAMRDYKKV QIQLENLETS
VRDRCKKEFT DLMTEMMDMS SDLVGSGIPF LDYRAYAERI FFPGHQESPL RRDLDVPESR
RQTVEQGLVQ LSNLLNSKLF LTKFIHTLEV QRTFSPRDRA YVASLLTVAL HGKLEYFTDI
LKTLLNDLVE QYVAKNPKLM LRRTESVVEK LLTNWMSICL YTFLRESAGE SFYMLFRAIK
HQVDKGPVDA VTGKAKYTLN DNRLLREDVE YRTLTLNVAM PATAAGGAAT NQTVPAKVLD
CDTITQVKEK VLEQSWKGMS FSQRPHIDSL HLEWRAGVAG HLILSDEDLT SVVQGSWKRL
NTLQHYKVPD GATVALVPRN NKHHLHDNHD YMPGEKTPML DDGEEGGVRL WHLVKASDES
ELPKHRRGSV REKGGERAKA IPEIYLTRLL SMKGTLQKFV DDLFTAILST SRPVPLAVKY
FFDLLDEQAL QHNISDPETI HIWKTNSLPL RFWINILKNP QFIFDVQTSD HVDAVLSVIA
QTFMDSCTIA DHKLGRDSPI NKLLYARDIP RYKQMVERYY ADIKQTISAS DQEMNSALAE
LSRNYAAEVN CHVALHELYK YINKYYDQII TALEEDATAQ KMQLGYRLQQ IAAAVENKVT
DL
//
