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Database: UniProt
Entry: M3ZJ92_XIPMA
LinkDB: M3ZJ92_XIPMA
Original site: M3ZJ92_XIPMA 
ID   M3ZJ92_XIPMA            Unreviewed;      2766 AA.
AC   M3ZJ92;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   22-NOV-2017, entry version 27.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 1a {ECO:0000313|Ensembl:ENSXMAP00000002284};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000002284, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000002284}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000002284};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000002284}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000002284};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000002284}.
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DR   EMBL; AGAJ01008437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01008438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01008439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01008440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01008441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000002284; -.
DR   Ensembl; ENSXMAT00000002289; ENSXMAP00000002284; ENSXMAG00000002253.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; M3ZJ92; -.
DR   OMA; MSVWSNI; -.
DR   OrthoDB; EOG091G00T2; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2327   2345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2351   2368       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2373   2391       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2411   2438       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2459   2481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2587   2610       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    164       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      171    221       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      229    285       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      292    371       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      377    433       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2704   2752       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2766 AA;  315580 MW;  F92FD8578402E18C CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PDAGDLSNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGG NTDTVLLNKL HHAADLEKKQ NDSENKKLLG TVIQYGHVIQ
     LLHLKSNKYL TVNKRLPALL EKNAMRVMLD TAGNEGSWFY IQPFYKLRSI GDSVVIGDKV
     VLNPVNAGQP LHASTHQLVD NPGCNEVNSV NCSTSWKIVL FMKWSDNQER VLKGGDVVRL
     FHAEQEKFLT CDDHRKKQYV FLRTTGRQSA TSATSSKALW EIEVVQHDPC RGGAGYWNSL
     FRFKHLATGH YLAAEVNPEY EEEGLDFRSP LDSEQDPLRA RLKIVQDKVL YTLISVPDGN
     DISSIFELDP TTLRGGDSLV PRNSYVRLRH LCTNTWVHST NQPIDKEEEK PVMLRIGTSA
     YKEDKEAFAI VPVSPAEVRD LDFANDASKV LASIAGKLEK GTITQNERRA VTKLLEDLVF
     FVVDIPNNGQ DVLEIMVNKP NRERQKLMRE QNILKQIFKL LQAPFTDSGD GPMLRLEELA
     DQRHAPFRHI CRLCYRVLRH SQQDYRKNQE YIAKQFRFMQ KQIGYDVLAE DTITALLHNN
     RKLLEKHITA AEIDTFVSLV RKNREPRFLD YLSDLCVSMN KSIPVTQELI CTAVLDPANA
     DILIETKLVL SRFEIEGSQL GENSVEVEED EEEVWLFWNN SDKEMRSKSV REMAQDAKEG
     QKEDKEVISY YRYQLNLFAR MCLDRQYLAI NKISIQLDVD LILRCMSDED LPFDLRASFC
     RLMLHMHVDR DPQEQVTPVK YARLWSEIPS KISINDYDND GTTKDNIKER FWQTMEFVEN
     YLRDVVCQNF PFADKEKNKL TSEVVNLARN LIYFGFYNFS DLLRLTKILL AILDCVHVST
     VFPFTKLEKG DGGRGSNVMR SIHGVGELMS QVVLRGGGFL PINTNSDSNG DTVKTQIEPE
     KQDILVMDTK LKIIEILQFI LNVRLDYRIS CLLSIFKREF DESTSQNELS ISGSVEGPNN
     IPGALDFENI EEQAEAIFGG SEENTPLDLD DHGGRTFLRV LLHLTMHEYP PLVSRALHLL
     FRHFSQRQEV LQAFKQVQLL VTSQDVDNYK QIKEDLDKLR SIVEKSELWV YKRQGPDEGL
     DGGEGMPAEP EPQKDAAATD KPRKAESASS KNYRVIKEVL LRLSRLCIQE GLSGRKSRKQ
     QQRLLRNMGA HAVVLELLQI PYEKGEDVRM QDNMKLAHQF LQNFCAGNQQ NQTLLHKHIN
     LFLNPGILEA ITMQHIFMNN FQLCSEINDR VVQHFVHCIE THGRNVQYLK FLQTIVKAEN
     KFIKKCQDIV MAELVNAGED VLVFYNDRAS FQTLVNMMRS ERDRMDENSP LRYHIHLVEL
     LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HDDCIPEIKI AYINFLNHCY VDTEVEMKEI
     YTSNHMWKLF DNFLVDICSV CNNTSDRKHA DNVLERYVTE TVMSIVTTFF SSPFSDQSTS
     LQTRQPVFVQ LLQAIFRVYH CYWLGSGQKG SVEACIKVLS DVAKSRAIAI PVDLDNQVNN
     LFVRSNNIVQ RTAISWRLSV RNSHLSARRE SVVTVSRDYR NIIERLQDIV SALEDRLRPL
     VQAELSVLVD VLHRPELLFP ENTDSRKKCE SGGFICNCKV LLRLYKQLLE ENEEKLCIKV
     LQTLREMMTK DRGYGEKMLQ STFTCLINTE LPGLSASVNS SRQKLDQNVS PKLLADQRRG
     EALRQILVSR YYGNFHRSSG RRDSLTSFGN GPLSPVGPGR SQSALGGPGG LSRGEMTLSE
     VQCHLDKEGA SDLVIDLIMN TTSDRVFQES ILLAIALLEG GNTTIQRSFF CRLTDDKNSE
     KFFRVFYDRM KSAQQEIKAT VTVNTSDLGN KRRDEDNQDR DAPVRKKSFA AARDSTVSMT
     EDVKEQLIEA SSATKKAFNS YRREADPEDH CSSTDGLPSA GAKNQEEKMS FVVVIMQPIL
     RFLQLLCENH NRDLQNFLRN QNKKNNYNLV CETLQFLDCI CGSTTGGLGL LGLYINEDNV
     ALINQTLESL TEYCQGPCHE NQNCIATHES NGIDIIIALI LNDINPLGKK RMDLVLELKN
     NASKLLLAIM ESRHDSENAE RILYNMKPKE LVEVIKKAYL QGEVEFVDIK EEEDVRDEEE
     HDAASPRNVG HNIYILAHQL ARHNKELSMM LKPGGGSGDG DEALEFYAKH TAQIEIVRQD
     RTMEEIVFPV PNICEFLTSE SKLRVYYTTE RDEQGSKIND FFLRAEDLFN EMNWQKKLRA
     EPVLYWCSRN MSVWSNISFK LALLMNLLVC FFYPLEGVHG GILEPHLSAL LWMGFFAALV
     LVLLMPKPLG ILALVAVTIL RLIFSVGLEP TLFLLGAFNV CNKIIFLVSF VGNRGTFTRG
     YKAMVMDFEF LYHLLYLIIC CLGVFGHVFF YSLLLFDLVY REETLLNVIK SVTRNGRSIV
     LTAVLALILV YLFSIVGYIF FKDDFILEVD RIANATQKSG ASLTGEFLNT GLCQGGLNEN
     CSNSAQQEEF GIDGEDENDM ERTCDSLLMC IVTVLSHGLR SGGGVGDVLR KPSKEEPLFA
     ARVIYDLLFF FMVIIIVLNL IFGVIIDTFA DLRSEKQKKE EVLKTTCFIC GLERDKFDNK
     TVTFEEHIKE EHNMWHYLYF IVLVKVKDST EYTGPESYVA EMIKEHNLDW FPRMRAMSLV
     SSDSEGEQNE IRNLQEKLES TMRLVINLSG QLTELKEQMT EQRKQKQRLG LLGHPPHLNI
     NPQQPA
//
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