ID M3ZMQ4_XIPMA Unreviewed; 1132 AA.
AC M3ZMQ4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 11 {ECO:0000313|Ensembl:ENSXMAP00000003497.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000003497.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000003497.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000003497.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8083.ENSXMAP00000021958; -.
DR Ensembl; ENSXMAT00000003502.2; ENSXMAP00000003497.2; ENSXMAG00000003498.2.
DR Ensembl; ENSXMAT00000030441.1; ENSXMAP00000021958.1; ENSXMAG00000003498.2.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000155333; -.
DR HOGENOM; CLU_008281_0_0_1; -.
DR OMA; PACNINC; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 6.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24035:SF127; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 11; 1.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF00053; Laminin_EGF; 7.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00180; EGF_Lam; 15.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00022; EGF_1; 14.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 10.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1132
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041118297"
FT TRANSMEM 858..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..104
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 153..183
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 196..226
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 234..269
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 282..312
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 320..355
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 495..530
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 581..616
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 669..704
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 717..747
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 798..833
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1111..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1132
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 173..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 216..225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 259..268
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 302..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 345..354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 520..529
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 606..615
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 694..703
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 737..746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 823..832
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1132 AA; 121334 MW; 581606313FBC8DD5 CRC64;
MGSSVVRLAW FLILSFTTSA LSLNPDDPNV CSHWESYAVT VQESYAHPFD QIYYTRCTDI
LNWFKCTRHR ISYKTAYRRG VRTMYRRRSQ CCPGYFESGD LCVPLCTEEC MHGRCVSPDT
CQCEPGWGGL DCSSASTANG TGCESDFWGP HCSNRCQCRN GAKCNPITGA CVCTDGYQGW
RCEDLCENGY YGKGCLLPCQ CLNGATCDHE TGECICASGY TGAFCGERCP SGSHGPQCEQ
RCPCQNGGTC HHITGDCSCP AGWTGLVCAQ PCPLGKYGIN CSKDCSCRNG GLCDHVTGKC
QCTAGFSGRR CQEDCPVGTY GPQCNQRCEC QNGAKCHHIN GACLCETGFK GPNCQERFCP
SGLYGLICDK YCPCNTTNTV SCHPLSGECT CSPGWTGLYC NETCPPGFYG EGCFLPCSCT
NGADCHPVTG ICTCAPGFMG EDCATVCPPG LFGPSCMSTC SCHNQASCSP VDGSCICREG
WQGVDCSIPC SSGTWGLGCN QTCLCSNGAA CDPVDGTCAC SPGWRGEHCH ESCPDGTYGL
DCRERCDCSH ADGCDPVSGF CRCYPGWTGI HCDSVCPQGF WGPNCSVSCS CQNGGSCSPE
DGTCVCAPGY RGTSCKRICS PGFYGHRCSQ TCPQCVHSIG PCHHVTGHCE CLSGFTGSLC
NQVCPSGRYG RTCAEICLCT NNGTCNPIDG SCQCFPGWTG DDCSQACPSG HWGPDCLNSC
NCHNGAQCSA YDGECRCSPG WTGLYCTQRC PSGFYGKDCS EVCRCQNGAD CDHITGQCVC
RTGFIGTGCE QKCPAGTFGY GCQLLCECLN NATCDYVTGT CYCSPGYKGI RCDQALMMEE
LNPYTKISPA RGSERQSAGA VMGIIFLLLI LMAMLSVFVW YRQRQRDKGQ EIQPSVSYSQ
AMHINNTDYS LSECGSTVAM RTSVSEINQN QNSTSSTAQC FSNPSYPTVA QCNVVSTISS
NLDGTLTLKS STLKSRNASE WRAFCNLNDI EVQQNEAQPQ KASRKDYIKS SMCNNSSCSL
NSDNPYATIR DPPGLACKHT ESSYVEMKSP SHREVPFGGT ATLLGTVSRN LYDVEPTVSI
LQGPNGMATG FSQGPYDLSC GRNIPSHYDI LPMRHSPTHT PPAPPESPSS LL
//
