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Database: UniProt
Entry: M3ZNQ9_XIPMA
LinkDB: M3ZNQ9_XIPMA
Original site: M3ZNQ9_XIPMA 
ID   M3ZNQ9_XIPMA            Unreviewed;      4882 AA.
AC   M3ZNQ9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSXMAP00000003852};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000003852, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000003852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000003852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000003852}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000003852};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000003852}.
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DR   EMBL; AGAJ01025214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01025215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01025216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01025217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000003852; -.
DR   Ensembl; ENSXMAT00000003857; ENSXMAP00000003852; ENSXMAG00000003826.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; M3ZNQ9; -.
DR   OMA; THEKWSL; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4416   4437       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4486   4507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4682   4704       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4763   4786       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    216       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      224    279       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      285    343       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      353    409       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      601    800       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1017   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1261   1473       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3948   3983       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4882 AA;  552412 MW;  61D3F438A8390E57 CRC64;
     MTATREGEDE GQFLRTGDEV VLQSTFTSHN EHLKLCLAAE GFGSRLCRLE PTSNCKNVPP
     DLSVCGFILA QCLSVRALQE TLAHSEQLAA EGSNAKAGVA HRTLLYGQAV MFTHSFSGMY
     LSCLSSSQTS PDKLAFDVGL QEDKAGEACW WTVHPASRQR SEGEKVRVGD DLILVSVSSE
     RYLHLSFGTV SDNKSLSDSL IVSASFQQTL WSVAPICSGG AIAQGYLKGG ETLRLLHSHS
     DACLTIPCSK QGEELQRVMH YEIGSVSGHG RSLWRLEILR VAWSGRHTCW GEPFRLCHVT
     TGKYLGLMEE KGLHLVDRDK ADIKTTSFCF RSSKVKQDKL DAGKNTNTDC MGIPEIKYGD
     SMCYLQHLYS GLWLTYQATD VKCRLGGNLR KAILHSEGHM DDGLTLSRSQ REESHTAGLI
     RNTVSLFTHF IRSSKEGSLS SFCLPMETVT CSLQDLIKYF QSPLDEQSHE DKQKKMAALR
     KRQNMFKEEG VIDLVLDCID HLHHYSSDSY ITDATQWEAI VYLFYELLAA LIRGNRVNCA
     HFSSSVDWLI GRLDHLEASS GVLEVLHCVL VESPEAINVI KDGHIQSIIS FLEKHGHNNK
     VLEVLCSLCV CHGVAVRSNQ NLICDSLLPD RDLLLQTRLT NQVTSMRANI FLAMGEASAQ
     HRRWYYELVV DHTDPFLTAE PTHLRVGWAF TEGYLPMPTG GEGWGGNGVG DDLYSFGFDG
     LHLWSGCVGR KVSSPFSHLL KDNDVVSCCL DLTVPCISFR VNGLPVQGML ENFNANGLLY
     PVVSFSAGVR VHFLFGGGHG EFRFLPPPGY ASCSEALLPK VKLRVEPCQK YISDCEEGKK
     ELIGPLVPVT PVTFTPTPVD ISKVVLPPQL EDIREKMAEN FHELWVKDRI DLGWTNGPVK
     DEGKRHDPCL MEFSKLPEQE RNQNLQMAED ILKTVLALGF HIGLADDHAE ERIKYMRLHT
     KYELPCGYRP APIDLRQITL SSADKDVVTL LAENHHNIWA RERIKQGWTY GPEQDVKGKR
     SPHLVPYSLV DERMRKAGME RGAVCLLLAF GYSLESLSQE QTPLSKPCLF SVEKSRVFRP
     DKSYAVTMGK WYFEFEVLTA GNMRVGWARP GCTPDKELGS DDQAYVFDGF EAQWCHQGGE
     PLGRRWLRGD VVGCLVDVFE GTMMVTLNGE LLFNDRGSEL AAKYLDIRDG LLPVVSVGVN
     QVGRMNLGRQ VESLQYFNVC GQQEGYKPFA FNMTRDPSLW MSWKLPQFTS VLPDDHSLQV
     TRLRGSMDSL SSLRVSQRVL VQHGGGSEMG FYRLSMPIQC AATLRSPAEG GLQVPSSSLT
     PSSGLEALLA ERTPTEYYYA VRILPGQEPF NVWIGWVTSD FHQHGSTFDT DNVGTVTVTL
     GDDGGKVQES VKRSNSFMVC AGEATGLSQS RRSAGLEIGC LIDTATGLLT FTSNGIEMST
     FFQLEAGTKL FPAVFVKPTT SNMFQFELES IKNAMPLSSA LLRSQRRNPC PLCPPRFQVQ
     YLKPVTWTRV PDSGLKVFVD WPDEHHGWRV QCFDPQQVMT LQIPDENKCV DILELSELDD
     LLAFHQNILL LYCSLCALGN TRVCHALCSH VDQSQILYAI QNPHLPGPLR LAYYQLFIQV
     YLSSHTTACL TMNHEYIIPM TDQAREASFY LSRVNGVSDG GNGQTPEGTC RSTCLKPQMR
     FSSPCFVRGD GTEAEDSPEI PLDTLRNLTA DMLTAGVVAV GQGMRDPAGG SVELLLVPIL
     RLLYNLLVMG VFEDEDLVRV LRLIEPNVFS KNVKTVEEAK DGKQRGKSIN KKEDDAIKQG
     LLQMELPEPV QLELCHLLSY LCDCQVRHRV EAVTAFSGNF VRQLQENQRF RYTQVMQALN
     MSAALTARKT KEFRLPPQEQ KISHREKINL LLSFREDEQQ ENCPCPVELQ QLLRDFHHLL
     NTHCGTETVP DSEEEDDTKM SLKDWLFSRA AKAVGLKKKP TEVEKYKSPS LKSLRRLISE
     MMVCWAQERE IEDPGLVRAI FTLLYRQYQG LEGQMEGSLS KAYAISQSSV EDTMALLSSL
     GQIRSLLSVR MGKEEEKLMN RRLGDIMNNK VFYQHPNLMR ALRMHETVME VMVNVLGEGE
     SKEITFPKMV ASCCRFLCYF CRISRHNQGA LFDRLTYLLE NSRVGLASPS KRGSTPLDVA
     AASVMDNNEL ALSLKESDLE KVVQYLALCG LQSCSLLLAK GYTDIGWNPV EGERYVDFLR
     FAVFCNGESV EENAYVVLGL LIRRPECFGP ALRGDGGDGL LAAMKEAISI SQDPSMDGPF
     PSQHPSRTYR DAAHSNEDDL IHMGHAIMTF YSALIDLLGR CAPEMHLIQG SKGEAIRIRA
     ILRSLIPVQD LEGVISICFQ LPSVSEDGVL VEPDLSTVFC PDHKAAMVLF LDRVYGVESQ
     SFLLHLLEVG FLPDLHAAVS LDTTDLGSTD MALALNRYLC TAVLPLLTKC SALFHDLEDH
     ALVVDSVIQA IYRLSRALSL TRAQRDTTED CLLALCRKLQ PSMMQPLLQR LVFDVLHLSD
     HSKLPLKMLT SHYEQMWKYY SYTGSQDKQK LASEGELQLS RKLFWGVFKA LTKKSFIPQL
     LSLCVQCLVA VAKALPPDYV EPGCLSQVDR ITSVDTDGYF EPQPVDTSNV SVPERLDFVV
     NKYAEHTHEK WSLEKFASGW VHGDQLCENT QVHPLLKPYR ALAEKEKDSY RWAIKETIKS
     MLAFGWTIER TKEGDAFGIH ACARRVSQAG QLSFEGASTF SPKPLDMSSI TLSWEQCAMA
     EQLAENYHNA WAKTKKLELE SRGGGHSMLV PYDALTAKEK TKFREKAQEI LKFLLLHGYT
     VWRDRKSVEI DFPATANCFG HIFLQRMLYY TEETQEDMLK LEVIQARGQM PKGERAQNQQ
     PIIFFQKVVL PLLEQYVKSH RLYFLSSSLN SSENRSHASK REKEMVLCLF CKLAALVRHR
     ISLIGDEASA VTSCLSILAQ ALDARILTAA ASESIQTSLH SFFEAAAADL EMTVGKISET
     LPHSRGQLSK GVVNTLNYTT SILMPTLTSL FHHLANENYG VDVLVGGIQV SCYKILNSLY
     SLGTSKSFYM EGQRSAAGAC VAALTGAFPV CFLEPTLDHN NPHSIYNVMS PTEIKDQGLP
     DRMEDTCCPL PSLGEALEKV EELTCAGSVA HQMQYIHVAE VTLPMLCSYI SHWCRWGPEG
     HPEGPVLSSV VPQHASDLIG HILRIIHNHV GASQGDWMKQ LAVFSQPIIC KADSELLRSH
     FLPLMEKLRK RAECVQLEEE VMKAEECCSS EAELQIQEKY RVLVQDLYSF YPLLIQFVDF
     NRARWLKETI PEAEQLFSMV AEVFVFWAKS HHFKWEEQSY VVQNRINNLA FLLSGDNMLE
     CNTETYVFSL HDKFDHKNKG MKRKGDRYSA HTSLIVATIK KLVPVGLRVC FPCDQNLIML
     VKNCYSQNNL EDEIREHILR YLKHVFDSIS KAVCYKILNL IFLTTQLEAP PDTQRTVDRV
     LEIARVLYYL DQVEHPQRSK KPAWNKILSK QRKRAVVACL RMTPLYNLPL HRAVNLFLQG
     YNRSWISTEG NDLVEMLVED LAEGEKREVK EVEEGAKAID PLLQLIMLFS RSALTESSKL
     DNDNLYKNYA AILAKSCRRE SQDDAEQEVE SFEEKEMEKQ KLLYQQARLH CRGAPEMVLQ
     AISAGHGTMG FMIGPTLKLG IALLNGGNAT VQQKMLDYLR EKRNVGFFQS MAGLMRSCSV
     LDLNAFERQN KAEGLGMATD ESSAIFSFKG EKVMPDKDLT CDLFRFLQLL CEGHNSDFQN
     YLRTQTGNNT TVNMVISTVD YLLRVQESIS DFYWYYSGKD VIDPLGQHNF SKAIEVAKQV
     FNTLTEYIQG PCIGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSRQIK LLKELMDLLK
     DMVVFLLSML EAGNVINGTI GKQMVDMLVE SSANVEMVLK FFDMFLKLKD LTSSEGFREY
     DSDCKGSICR KDFQKAMENC KYFSQAEIHF LLSCIEANDS EILEYETFVD RFHEPAKDIG
     FSIAVLLTNL SEHMPKESKL KTFMELAECV LTYFQPSLGR IEILGSGKRF ERVYFEISEY
     SRTQWEKPQV KESKRQFIFD VVNKGGDKDK MEMFVNFCED TIFEMQLAAQ ISGSNSGEKC
     NGKTELEKSE LEEYTSPDYK RWTFIYYWWV MLTCALSGKN LRTLMKMTPK DFLLAAVRFI
     RFICALQIHC ISAVICRIMY LLYITFVNSG LIEAAKRMKV SDLLGGILEP TLDEVMEVSS
     SVDQKELREI GQMASLTFPK EVDILSDIFG LKLKKEGDQY RLVTQDLSDS LTDLFSSTSR
     TMNDTDVSEE HHTLQFTDHL DKEKTEDEKM ENLQEKENVF RWKKTEKDRR NAKEEKKHGA
     KKCSNMSKEP QRQHSAVWET ISSHSKRLLN YFARNFYNMR LLALFVAFAI NFILLFYKVA
     FLPASKEKQV TTSAYGKELL SAMTNTSNGK VYFVLEESSG YMELCLHFLS IAHTIISFCC
     IIGYYCLKVP LVIFKREKEV ARRLEFDGLY VTQQPPEEDI KGQWDRLLIN TLSFPSNYWD
     KFVKRKVMDK YGDFYGRKKI SELLGLDQAA LDFSTKRKEQ KRLRRDSAWS VLFNSLDAKY
     QVWKLGVVFT DNSFLYLAWY MTMSVLGHYN NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK
     QLVLTVGLLA VVVYLYTVIA FNFFRKFYNH SRGKETEEMK CNDMLTCYMF HMYVGVRAGG
     GIGDEIEDPA GDEFEVERIV FDITFFFFVI VILLAIIQGL IIDAFGELRD QQEQVKEDME
     TKCFICGIGS EYFDKIPHGF ETHTLQEHNL ANYLFFLMYL INKDETEHTG QESYVWKMYQ
     ERCWEFFPVG DCFRKQYEDQ LG
//
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