GenomeNet

Database: UniProt
Entry: M3ZPF5_XIPMA
LinkDB: M3ZPF5_XIPMA
Original site: M3ZPF5_XIPMA 
ID   M3ZPF5_XIPMA            Unreviewed;       846 AA.
AC   M3ZPF5;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-SEP-2017, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000004098, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000004098}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004098};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000004098}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004098};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000004098}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AGAJ01032429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005812050.1; XM_005811993.1.
DR   STRING; 8083.ENSXMAP00000004098; -.
DR   Ensembl; ENSXMAT00000004103; ENSXMAP00000004098; ENSXMAG00000004058.
DR   GeneID; 102227465; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; M3ZPF5; -.
DR   OMA; GPQYEEF; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    407    431       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    452    470       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    546    564       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    576    599       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    776    799       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       92    126       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   846 AA;  96693 MW;  3D6105B59BD383B6 CRC64;
     MVFRSEEMCL AQLFLQSGSE YDCISELGEL GLVEFRDLNP SVSSFQRRFV SEIKRCEEME
     RILGFLLREI QKAKIAVPQE DESPLAPPPR QVLEIMEQLQ RLEMELSEVA KNKDKLQRNL
     LELTEYTHML KITRSFIHSR SRHEALGPQY EEFPTMETDS ATGSTGMQRL GAKLGFISGL
     IQRVKVEAFE RMLWRVCKGY TILSYTEVDE SLADLDTGEI NKSVVFLISF WGDQIGHKVQ
     KICDCYHCHL YPHPENDEER ADVLDSLRTR IQDLNNVLHR TDDYLRQVLQ KAAESAYAWV
     VQVKKMKAIY HILNLCSFDV TNKCLIAEVW CPVSDLANLR GALEKGSRKG DATVPSFVNR
     IPSSDTPPTL LRSNKFTTGF QSIVEAYGVG DYREVSPAPY TIITFPFLFA VMFGDLGHGM
     IMSLFALWMV LTEKNQKKKR SSNEIWMTFF HGRYIILMMG LFSIYTGLIY NDCFSKSLNI
     FGSGWSVKAM FTNQQWTNKT VQTNALLTLD PNVSRVFSGP YPFGIDPIWN LAVNRLSFLN
     SYKMKMSVIV GVIHMSFGVV LSVFNHLHFG QKFSVYLLFL PELLFLICLF GYLVFMILYK
     WLAFSAHNSS QAPSILIHFI NMFVMQGKDV TPLYPGQTGL QVFLLLIAVM CVPVLLLGKP
     LYLYWQQRGG KGLRRRRGYE RVRRVSEDDG SITSIHEEDE EEGFDEVTSR EAPPKQFDFA
     DVLMHQAIHT IEYCLGCVSN TASYLRLWAL SLAHAQLSEV LWAMVMRLGF KITTKVGVVF
     LVPVFGLFAT LTVSILLVME GLSAFLHALR LHWVEFQNKF YHGTGVKFLP FDFSQLPSVF
     EQDGLL
//
DBGET integrated database retrieval system