ID M3ZPF5_XIPMA Unreviewed; 846 AA.
AC M3ZPF5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 28-MAR-2018, entry version 26.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC Poeciliinae; Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000004098, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Ensembl:ENSXMAP00000004098}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004098};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSXMAP00000004098}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000004098};
RG Ensembl;
RL Submitted (MAR-2013) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC ATPase), a multimeric enzyme that catalyzes the translocation of
CC protons across the membranes. Required for assembly and activity
CC of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|RuleBase:RU361189}.
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DR EMBL; AGAJ01032429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005812050.1; XM_005811993.1.
DR STRING; 8083.ENSXMAP00000004098; -.
DR Ensembl; ENSXMAT00000004103; ENSXMAP00000004098; ENSXMAG00000004058.
DR GeneID; 102227465; -.
DR KEGG; xma:102227465; -.
DR eggNOG; KOG2189; Eukaryota.
DR eggNOG; COG1269; LUCA.
DR GeneTree; ENSGT00390000004941; -.
DR InParanoid; M3ZPF5; -.
DR KO; K02154; -.
DR OMA; GPQYEEF; -.
DR OrthoDB; EOG091G01BI; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629; PTHR11629; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 407 431 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 452 470 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 546 564 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 576 599 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 642 665 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 776 799 Helical. {ECO:0000256|RuleBase:RU361189}.
FT COILED 92 126 {ECO:0000256|SAM:Coils}.
SQ SEQUENCE 846 AA; 96693 MW; 3D6105B59BD383B6 CRC64;
MVFRSEEMCL AQLFLQSGSE YDCISELGEL GLVEFRDLNP SVSSFQRRFV SEIKRCEEME
RILGFLLREI QKAKIAVPQE DESPLAPPPR QVLEIMEQLQ RLEMELSEVA KNKDKLQRNL
LELTEYTHML KITRSFIHSR SRHEALGPQY EEFPTMETDS ATGSTGMQRL GAKLGFISGL
IQRVKVEAFE RMLWRVCKGY TILSYTEVDE SLADLDTGEI NKSVVFLISF WGDQIGHKVQ
KICDCYHCHL YPHPENDEER ADVLDSLRTR IQDLNNVLHR TDDYLRQVLQ KAAESAYAWV
VQVKKMKAIY HILNLCSFDV TNKCLIAEVW CPVSDLANLR GALEKGSRKG DATVPSFVNR
IPSSDTPPTL LRSNKFTTGF QSIVEAYGVG DYREVSPAPY TIITFPFLFA VMFGDLGHGM
IMSLFALWMV LTEKNQKKKR SSNEIWMTFF HGRYIILMMG LFSIYTGLIY NDCFSKSLNI
FGSGWSVKAM FTNQQWTNKT VQTNALLTLD PNVSRVFSGP YPFGIDPIWN LAVNRLSFLN
SYKMKMSVIV GVIHMSFGVV LSVFNHLHFG QKFSVYLLFL PELLFLICLF GYLVFMILYK
WLAFSAHNSS QAPSILIHFI NMFVMQGKDV TPLYPGQTGL QVFLLLIAVM CVPVLLLGKP
LYLYWQQRGG KGLRRRRGYE RVRRVSEDDG SITSIHEEDE EEGFDEVTSR EAPPKQFDFA
DVLMHQAIHT IEYCLGCVSN TASYLRLWAL SLAHAQLSEV LWAMVMRLGF KITTKVGVVF
LVPVFGLFAT LTVSILLVME GLSAFLHALR LHWVEFQNKF YHGTGVKFLP FDFSQLPSVF
EQDGLL
//
