ID M3ZXY8_XIPMA Unreviewed; 1644 AA.
AC M3ZXY8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSXMAP00000007082.2};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSXMAP00000007082.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007082.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007082.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007082.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 8083.ENSXMAP00000007082; -.
DR Ensembl; ENSXMAT00000007090.2; ENSXMAP00000007082.2; ENSXMAG00000007067.2.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000155279; -.
DR HOGENOM; CLU_000134_7_1_1; -.
DR InParanoid; M3ZXY8; -.
DR OMA; WISRRCA; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF173; ANKYRIN-3; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 3.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 43..75
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 76..108
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 109..141
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 142..165
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 212..244
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 245..277
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 278..310
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 311..343
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 344..376
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 377..409
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 410..442
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 443..475
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 476..508
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 509..541
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 542..574
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 575..607
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 608..640
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 641..673
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 674..706
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 707..739
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 740..772
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 938..1126
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1128..1275
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1444..1526
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 1644 AA; 181114 MW; 6D97EE281EDDF593 CRC64;
MFFSCLFQSD SNTSFLRAAR AGNIDKVLEY LKGGVDISTC NQNGLNALHL AAKEGHVDLV
QELLDRGASV DSSTKKGNTA LHISSLAGQA EVVKILTKRG ADINSQSQNG FTPLYMAAQE
NHMDVVRYLL ENGGNQSIAT EDGFTPLAIA LQQGHNQVVS ILLENDTKGK VRLPALHIAA
RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT LLLNRGAAVD
FTARNGITPL HVASKRGNTN MVRLLLDRGS QIDAKTRDGL TPLHCAARSG HETAVELLLE
RGAPLLARTK NGLSPLHMAA QGDHVECVKH LLQHKAPVDD VTLDYLTALH VAAHCGHYRV
TKLLLDKRAN PNARALNGFT PLHIACKKNR VKVMELLVKY GASIQAITES GLTPIHVAAF
MGHLNIVLLL LQNGASADVS NIRGETALHM AARAGQVEVV RCLLRNGAMV DAQAREDQTP
LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE GQVETASVLL EAGASHSLAT
KKGFTPLHVA AKYGNLDVVK LLMQRCAPPD SAGKNGLTPL HVAAHYDNQQ VALLLLDKGA
SPHAMAKNGY TPLHIAAKKN QMDIATVLLQ YGAETNILTK QGVTPLHLAS QEGHTHMTAL
LISKGAQINV STKSGLTALH LAAQEDRVSV AEILSKNGAN LDHQTKLGYT PLIVACHYGN
VKMVNFLLQN GASVNAKTKS GYTPLHQAAQ QGNTHIINVL LQYGAKPNAI TVNGNTALGI
ARRLGYISVV DTLRVVTEEI ITTTTTVTEK HKLNVPETMT EVLDVSDEEG DDTMTGDGGE
YLRPEDLKEL GDDSLPGQYL DGMNYLRFSL EGTRTERYQM LHHTTSLIYS QEQHISDKNY
YTVSSLAREN ERDSYRLSWG TENLDNIALS SSPIHSGFLV SFMVDARGGA MRGCRHNGLR
IIIPPKKCSA PTRVTCRLVK RHRLATMPPM VEGEGLASRL IEVGPSGAQF LGKLHLPTAP
PPLNEGESLV SRILQLGPPG TKFLGPVIVE IPHFASLRGK ERELVILRSE AGESWKEHQC
EYTPEELNRI LNGMDEELDP PEELERKRLC RIITRDFPQY FAVVSRIKQD NNLIGPEGGI
LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP VNASVVRKIL GNKASFSPIV TLEPRRRKFH
KPITMTIPVP KSNSDPILNG FGGDTPTLRL LCSITGGTTP AQWEDITGTT PLTFINDCVS
FTTNVSARFW LIDCQQVQES VNFSTQVYRE IICVPYMAKF VIFAKTHDPI EARLRCFCMT
DDKIDKTLEQ QENFTEVARS RDVEVLEGKP IYADCFGNLV PLTKSGQHHL FSFYAFKENR
LALFIKIRDN TQEPCGRLSF MKEPRNYRSL HQNAICNLNI TLPSYSKDSD SDQEHEEQDE
AERNEQRLAI IADHLGFSWT ELARELEFSE EKINMIRTEN PNSLQDQSHA LLNLWTVTEG
HTESTLIKRL TKINRMDIVH LIETKINKSA EEETSSHTYA EIEQTLMLDH SEGVKILVQE
VPVVSAEELS TSLSSLQETS GRFEAGQMAT EFMKKTDCHQ WYSATDLFLQ ADILPDIPPQ
TVTEEKYTDE HGNMVVKKVR NARQ
//
