ID M3ZYL9_XIPMA Unreviewed; 1003 AA.
AC M3ZYL9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=SH3 and PX domains 2A {ECO:0000313|Ensembl:ENSXMAP00000007313.2};
GN Name=SH3PXD2A {ECO:0000313|Ensembl:ENSXMAP00000007313.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007313.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007313.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007313.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; M3ZYL9; -.
DR Ensembl; ENSXMAT00000007321.2; ENSXMAP00000007313.2; ENSXMAG00000007295.2.
DR eggNOG; KOG4773; Eukaryota.
DR GeneTree; ENSGT00940000157732; -.
DR HOGENOM; CLU_013051_1_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd12074; SH3_Tks5_1; 1.
DR CDD; cd12077; SH3_Tks5_2; 1.
DR CDD; cd12019; SH3_Tks5_4; 1.
DR CDD; cd12020; SH3_Tks5_5; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035450; SH3PXD2A_SH3_1.
DR InterPro; IPR035452; SH3PXD2A_SH3_2.
DR InterPro; IPR035453; SH3PXD2A_SH3_4.
DR InterPro; IPR035454; SH3PXD2A_SH3_5.
DR PANTHER; PTHR15706:SF22; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 2.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..112
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 135..194
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 207..266
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 338..397
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 713..772
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 942..1003
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 109..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1003 AA; 111389 MW; 0EC5D2E55329EE7C CRC64;
WKIQLLNETT TEDLSYRDNK EMWCFNIPFI FYFLLMRILD KFPIEAGQKD PKKRIIPFLP
GKVLFRRSHI RDVAVKRLKH LDNYCNALMK LPSSISESEE VLKFFETRPE DLNPPTEDCG
GSGKRKSGLD ASDPMLLEQY VVVANYEKQE PAEISLQAGE LVDVIEKSES GWWFVSTAEE
QGWVPATYLN SHNGTRDDLE LGASKAGEEE KYITVQPYSS EGKDEIAFEK GVIVEVIQKN
LEGWWFIRYQ DKEGWAPASY LKKVKDDLSP RKKTVTGPVE IIGNIMEISN LLNKKTLSEK
NVQTEGVPES SPVLRQKPPP RRDATLGFQL PSPPEPPAVE AEYYTIADFQ SCISDGISFN
GGQKAEVIEK NSGGWWYVQI GEKEGWAPCS YIDKRKKPNL NRRTSTLCRP KVPPPAPPVK
KQDSVETAPP SSPGSDAPES PVSPSGPVYE EPEYDVPAIG DLDLESEFEF LRGESSLVDF
KNEETSSEKG SHLSSKPSPA SSLHSASFKL GESFEDGQEA EGEAGGEEEC IYENDGFLPF
RETPERQCSR DSNLSKTSVL SENGKTANQA SGGWRPAGNR LKIDLNGTPL SARSEQASSP
KSASSESTPD LSRPKKDNEE SKMTSFTKSS SKLRPVVRPK PQLAKASSAE KMDISTLRRQ
LRPTGQLKNG TKSKGEDSET ASVISSEDSF SSQSTSDLSS IYSKGSRGES DMDGFNLYRT
TDPYEKVQDS ELSFPAGVVV EVLEKQESGW WYIRWGDAEG WAPTYFLEPA RQQDDTGEYE
SYGTPTKPGC LSKSNSLEKN EQRVRVLNNI NLNLKKVMPP IPSKPPGGLS KPASLFSSLK
QNSTKQQQVV RPQSVFISAP IRDGASPAVS LRRNESLNST DNPRASPTVR RNASFGAVPR
SLPSNNRNRS GTGSSESLGL NSPKNALPVS PVKPKPHIIH NNLREVYVSI ADYHGDEETM
GFPEGTSLEV LERNPNGWWY CKILDNGRPR KGWVPSNYLE KKH
//
