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Database: UniProt
Entry: M3ZYX6_XIPMA
LinkDB: M3ZYX6_XIPMA
Original site: M3ZYX6_XIPMA 
ID   M3ZYX6_XIPMA            Unreviewed;      2289 AA.
AC   M3ZYX6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 30.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007420, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000007420}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007420};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000007420}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007420};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000007420}.
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DR   EMBL; AGAJ01035135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGAJ01035136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8083.ENSXMAP00000007420; -.
DR   Ensembl; ENSXMAT00000007428; ENSXMAP00000007420; ENSXMAG00000007358.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; FREDNLI; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 3.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     79     96       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    117    138       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    150    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    320    342       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    500    519       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    525    545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    625    647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    703    725       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1113   1131       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1151   1171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1183   1202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1244   1266       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1356   1381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1437   1455       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1467   1487       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1499   1518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1650   1674       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1812   1846       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      721    748       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2289 AA;  259133 MW;  154E8DEC2BB0071D CRC64;
     MARFADDLPT RYGGSAGGGG GGQRMYKQSM AQRARTMAIY NPNPVKQNCL TVNRSLFIFR
     EDNLIRKYAK RITEWPTPFE YMILATIIAN CIVLALEQHL PANDKTPMSE RLDDTEPYFI
     GIFCFEAAIK IIALGFAFHK GSYLRNGWNV MDFVVVLTGF KSVIAPAAVF FQHSILRLIM
     LIQPSDVASS LPNLPFSMKS SIKTNTKLLV VLLLRFIQQS QRITAFSLIN ILFMFRPIHK
     STFSASSAEL CYIFFPIGPP CRSCQLVKSG KEKWGGPNWS LESLNNSLFA ILVYSQNVRR
     RCWTRSLVNT NDAVGNNWNW LYFIPLIIIG SFFMLNLVLG VLSGEFAKER ERVEKRQEFL
     KLRRQQQIER ELTGYLEWIC KAEEVLLEEE DEIAEEKAPM DGAWYKRKQN LSGENRASAF
     KKSSLSVLKR GKIKKGKNDL IGAEEGDDPF ADMSSVVPPG SPFGRASVKS GGKMDSSSYF
     RRKEKRFRFF IRRMVKAQSF YWIVLCLVGL NTLCVAIVHY DQPDWLTRAL YTAELVFLGL
     FLTEMTLKMY GLGVRNYFHS SFNCFDFGVI VGSIFEVIWD MIKPGASFGI SVLRALRLLR
     IFKVTKYWNS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ FNFEDETPTT
     NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVRRGMY SSIYFIVLTL FGNYTLLNVF
     LAIAVDNLAN AQELTKDEEE QEEAANKKLA LQKALEVKEV SPMSAANISI AAKEQQRSAK
     TMSVWEQRTN QLRKHNMKTS TEALFNELDP DELLAASSAL HLHPDMKTHT DRPLVLEDKN
     GDQPRAGAPE EAAAPGVRDS FHSRRRHHHR DRNGDGGDGQ GVRRHSHHGR SREHNADAAQ
     DRERLRPQTG SPEEERGHRH HRSRRTPKEG NGRLTNGAQD DGKGRGDNGN GEKKLRSSRI
     QRWAEYPDVY WSKRRTTGAR KSPRNYSTKR DKQAETEDDS LAGSPLQLKR SSLTPSEKQE
     DADNQKNSTR ASQAALNSNA VHIPVTITAP PGETTIIPSE NLEFVNLSEE KKDLEEEEAA
     NGPRQILPYS SMFVFGQTNP VRRLCHYVVN LRYFEMCILI VITMSSITLA AEDPVEANAD
     RNIALKYLDY VFTGVFTFEM VIKMIDLGLL LHPGSYFRDL WNILDFIVVS GALVAFACSG
     TKGKDINTIK SLRVLRVLRP LKTIKRLPKL KAVFDCVVNS LKNVLNILIV YILFMFIFAV
     IAVQLFKGKF FYCTDESKGL EKDCRGQFLE YDRKEVTAQP REWKKYEFHY DNVLWAFLTL
     FTVSTGEGWP LVLKHSVDAT YEDQGPSPGF RMETSIFYVV YFVVFPFFFV NIFVALIIIT
     FQEQGDKAMS ECSLEKNERA CIDFAINARP LTRYMPENKQ SFQYKMWKFV VSSPFEYAIM
     TLIALNTVVL MMKFYDAPVV YESMLKYLNI IFTGLFTLEC ILKIIAFNPL NYLKEPWNVF
     DFVTVIGSIT DILFTEINKT SNNKMINLSF LRLFRAARLI KLLRQGYTIR ILLWTFVQSF
     KALPYVCLLI AMLFFIYAII GMQVFGNIEL NEETSINHHN NFQTFFQALT LLFRSATGEA
     WHEIMLACLS NRPCDKLSGS SGKECGSDFA YFYFVSFIFL CSFLMLNLFV AVIMDNFEYL
     TRDASILGPH HLDEFIRVWA EYDPAACGRI CYRDMYKLLR LISPPLGLGK KCPNRVAYKQ
     RLVRMNMPIA DDNTVHFTST LMALIRTALE IKLASGVLAQ RLCDADMKRE IHRVWPNLQQ
     KTVDLLVTPH KYNELTVGKV YAAHMIFDYY KQNRAKKLQQ QNPSGISQEP APPIKPALPP
     EPEPKTQAPP TFTSSTTTNV DANMDAILNQ RTSIKHSQSG DFSPVTARLK PRRRLQRGQS
     EDVHFCSRAQ ERQADPKPEN MSDSEGRPGL EGHARAASLP RLNAEYHRSH PRHAPGTHLA
     PIVDLSPIKR SASSLTPQQV GLREYDLERV DQSRFYAEPG PDPDPDRTHH HHHHHRCHRR
     RDKDRDRRQK SLDKTSSAPP SGTVGEPTER ARERDRSRPH ERRHHSSAGE KQRYYSCERY
     GSREPGQARS AGPSRSTSPG ESQDSGLIKQ VRGSTVTKPP SGTSAQARGR RQLPQTPLTP
     RPAVAYKTPT SSAATPSAST PGSRFVRGAS EHDRLLAAHE EPKAPVGPDS NPSRQQLDSS
     LPEEGEDFQD AVSSHGGGHS SRSATAPPTA AAQGRAAGVP NGYHFTLGSA PGSSRGAAGL
     REREEEDWC
//
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