ID M3ZZK7_XIPMA Unreviewed; 1059 AA.
AC M3ZZK7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|Ensembl:ENSXMAP00000007651.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007651.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007651.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007651.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; M3ZZK7; -.
DR STRING; 8083.ENSXMAP00000007651; -.
DR Ensembl; ENSXMAT00000007659.2; ENSXMAP00000007651.1; ENSXMAG00000007629.2.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000163875; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR InParanoid; M3ZZK7; -.
DR OMA; NFLPCCS; -.
DR OrthoDB; 4603490at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF4; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1059
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004046811"
FT DOMAIN 894..1042
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1059 AA; 120734 MW; D7F4C3A41035E53F CRC64;
MALEKVLLIV IQFLLYGNAI NIQFFPCDAD VNSTTVDCSN RPIKHIPIIK AATVLSIDLS
DTKVQAVRNH AFAGVPNVNI LKIKGNCLPG QLRLPEQQGC NMEIEPHAFK YLKNLTSLHL
SGNSLTSIPN LPENLLFLDL QYNCIFNIFV PLKTPNLETL LLSKNCFYAN PCNQSFYINA
TVFRGLPKLE NLTLGYDNVT AVPKDLPASL KVLDLRENTM TEVPEGSFAN LTALEYLNLE
WNCQRCDHAA RPCFPCPQNR PLQLHPNSLH SENSSITFLS LRGNSLKTFP DGLFRPLKNL
KELDISDNLL AFAIQNGTFF QELTGLTWIS LIYNYEPLKT FGELDLSPYI GNISGLQRLL
LSGNFFHTIS KKGFHVLSQL KNLSKLELRM NFISECNLTT LKQLPSLTAI DLSQNMLNFL
PCCSGSSGIA EPDSCQNQNL YSGDFQDVHT LIPDKETRTS SHIWESDQSN GPETTNGREC
QIPSLLSFKN KYCWQKLSFD LSQNDILSLN KRVFLGMEKA VCLDLSYNYM SQTLRGGQFN
NMTKLVFLNM SFNRLDLYRG DAFSELQSTL KVLDVSNNDF HFKMRGMGHR FEFLKNLTNL
EVLSLANNGI GMRIDRRLVS RSLQYLYFNG NHLDIMWNAD YNTYAHFFQN LTKLKFLDIS
SNNLKSVPAE VLCNLPVSLQ SLCISRNSMK NFPWQNISAL SNLCHLDLSY NSLSNLVSQE
IKFGDQFSFL DLSHNHLTSI PDNFFNEARS LQHLYLNHNK IKELNHQHLP APFQKGSTLQ
KLTLHENPFK CDCNTSWFVV YLRTTPVNIP YLTTRVRCGY PDSQQGVILL SIDQHSCQDI
FGSLAFLVCS FLSVTFTALP LLKHLYGWDV WYCLQVFWAG LKGYSQLPGG VSDHHYDAFV
VFDTRNLAVR DWVYNELTAN LECSDHRRFS LCLEERDWIP GLSCIDNLHS AVHSSVKTVF
VLSRSTNGTE LVNGVIRQAF FMVQQRLLDE KVDAAVVVLL DEMFPKLKYL QLRKRLCRKS
VLSWPRNPRA QPLFWNQMRM ALSSDNLKFY DNNMSESFI
//
