ID M4A0F5_XIPMA Unreviewed; 572 AA.
AC M4A0F5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Transmembrane anterior posterior transformation 1 {ECO:0000313|Ensembl:ENSXMAP00000007949.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007949.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007949.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007949.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TAPT1 family.
CC {ECO:0000256|ARBA:ARBA00008803}.
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DR RefSeq; XP_014328139.1; XM_014472653.1.
DR AlphaFoldDB; M4A0F5; -.
DR STRING; 8083.ENSXMAP00000007949; -.
DR Ensembl; ENSXMAT00000007957.2; ENSXMAP00000007949.1; ENSXMAG00000007925.2.
DR GeneID; 102233431; -.
DR KEGG; xma:102233431; -.
DR CTD; 559710; -.
DR eggNOG; KOG2490; Eukaryota.
DR GeneTree; ENSGT00390000010628; -.
DR HOGENOM; CLU_003655_3_0_1; -.
DR InParanoid; M4A0F5; -.
DR OMA; TIMLIRV; -.
DR OrthoDB; 1215898at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:1904888; P:cranial skeletal system development; IEA:Ensembl.
DR GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR GO; GO:1903012; P:positive regulation of bone development; IEA:Ensembl.
DR GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
DR GO; GO:0045724; P:positive regulation of cilium assembly; IEA:Ensembl.
DR InterPro; IPR008010; Tatp1.
DR PANTHER; PTHR13317:SF4; TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG; 1.
DR PANTHER; PTHR13317; UNCHARACTERIZED; 1.
DR Pfam; PF05346; DUF747; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 64682 MW; D19E88853D1884D3 CRC64;
MADSLSTGLV EEKEKEKEDR ERATKAVNAD QNKKKDGLTD TRGFHDKNGG ARGQKGNLSD
LSLVRFITTE LTRGYFLEHN EAKYTERRER VYTCLRIPKE LEKLMTFGFF LCLDTFLYVF
TLLPLRVILA LLRLLTVPCC GLGGSRLLQP AQVCDVLKGF IMVLCYSMMS YVDYSMMYHL
IRGQSVIKLY IIYNMLEVAD RLFSSFGQDI LDALYWTATE PKEKKRAHIG VIPHFLMAVL
YVFLHAILIM VQATTLNVAF NSHNKSLLTI MMSNNFVEIK GSVFKKFEKN NLFQMSNSDI
KERFTNYILL LIVCLRNMEQ FSWNPDHFWV LFPDVVMVIT SEVAVDVVKH AFITKFNDIS
ADVYGEYRAS LAFDLVSSRQ KNAYTDYSDS VSRRMGFIPL PLALLLIRVV TSSVKIQGSL
SFMCVLLFYL GMITLKVLNS IVLLGTSCMF VKEAKMEEKL FDPPPSVASS RANSRANRSK
STHTAAPQEP TSNSAGVSLT PGVSPPTEKP EGPSSAIPKS DSDTFLTTPD EDDEDKILNN
DMRLEGDGLK HRTPKKDLLE IDRFTICGNR ID
//
