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Database: UniProt
Entry: M4A209_XIPMA
LinkDB: M4A209_XIPMA
Original site: M4A209_XIPMA 
ID   M4A209_XIPMA            Unreviewed;       826 AA.
AC   M4A209;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-SEP-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008503, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Ensembl:ENSXMAP00000008503}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008503};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXMAP00000008503}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008503};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXMAP00000008503}.
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DR   EMBL; AGAJ01001142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005795350.1; XM_005795293.1.
DR   STRING; 8083.ENSXMAP00000008503; -.
DR   Ensembl; ENSXMAT00000008516; ENSXMAP00000008503; ENSXMAG00000008450.
DR   GeneID; 102231475; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; M4A209; -.
DR   OMA; WRACRGF; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002852};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    391    424       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    444    463       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    541    562       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    568    592       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    639    661       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    758    782       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       99    126       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   826 AA;  93811 MW;  84C7D5685874F334 CRC64;
     MGSLFRSEEV CLVQLFLQSD SAYNCVSELG ELGLVEFRDL NPNVNAFQRK FVSEVRRCEE
     LEKTFSFLEQ EINRSLKPPL QRPLAPPNPV PSAPQPRELI TIEEESERLA RELREVSRNR
     DSLRAQLTQL CQYKGVLTQT HSLTATQGPP PVLESHGLFD HRQDVRLSFV AGVVHPWKVP
     SFERLLWRAC RGYIIVDFRE MDDRLQHPDT GEMVQWTVFL ISFWGDQIGQ KVKKICDCFH
     TQTFVYPEST TEREEILEGL QGRIEDIKSV LSQTEAFLQQ LLQRAVALLP QWKVRVQKCK
     AIQLVLNLCS PSVTDKCLIA EAWCPTAKLP ELQSALREGG RKSGSGVDSF YNRLPCSTPP
     PTLFPLNSFT AGFQSIVDAY GVASYREVNP AVYTIITFPF LFAVMFGDVG HGLLMSLAAL
     WMVLEEKDPK LKNNSNEIWR MMFGGRYLIL LMGLFSIYTG AIYNECFSRG MKTFSSGWHV
     GPMFDKNIWS PLVLQGNQFL SMDPNVTGVF TSPYPFGIDP IWGLANNKLT FLNSYKMKMS
     VIIGVIHMTF GVCLSFFNYW HFGKISSIFF VLIPELFFML CLFGYLIFMV VFKWIVYTPA
     QSRIAPSILI HFIDMFLFTD NPENPQLYTG QPVVQKVLVV LALCSVPVLL LGKPLCEYVA
     FKSRRRRHID EERQPLVADE GSVNTRQGEV EGRPADEEEF DAADVFMHQA IHTIEYCLGC
     ISNTASYLRL WALSLAHAQL SEVLWHMVLH LALTWKGYVG SALLFVIFAA FAVLTVSILL
     VMEGLSAFLH ALRLHWVEFQ NKFYSGTGYK LSPFSFNALI HASAAI
//
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