ID M4A2C6_XIPMA Unreviewed; 656 AA.
AC M4A2C6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Calpain 10 {ECO:0000313|Ensembl:ENSXMAP00000008620.2};
GN Name=CAPN10 {ECO:0000313|Ensembl:ENSXMAP00000008620.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008620.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000008620.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008620.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR AlphaFoldDB; M4A2C6; -.
DR STRING; 8083.ENSXMAP00000008620; -.
DR Ensembl; ENSXMAT00000008633.2; ENSXMAP00000008620.2; ENSXMAG00000008593.2.
DR eggNOG; KOG0045; Eukaryota.
DR GeneTree; ENSGT00940000159706; -.
DR HOGENOM; CLU_010982_3_3_1; -.
DR InParanoid; M4A2C6; -.
DR OMA; ECALSCS; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF30; CALPAIN-10; 1.
DR Pfam; PF01067; Calpain_III; 2.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 2.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 12..321
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 72
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 242
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 267
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 656 AA; 73688 MW; D7B3526A4A25B48A CRC64;
MRFGFECAGP SLFEDLDFPT TDSSLFSDSS TPIAQLHGEI TWRRPQEICQ SPSLFPTNTN
LAHAKQGLLG DCWFLCACTF LLKNQHLLDK VFPPGQPQWG SSKYRGSFQF LIWQQGHWTE
VIVDDRLPCM NSCLCFSRCH SPSAFWIALL EKAYAKLHGS YEQLWAGQVS EALVDLTGGV
AECWSLREFG SDEEEQQAEQ DSDQVRRKKL DLNLLCCVKE ECALSCSTHS SPGGLSELDQ
HHALTVMEWL DVRKVSGSDV RLLRIRNPWG RCCWAGAWTW SGIGWSFLDP VCTAELRDRT
AEGEFWLDEA EFTSQFDDIT VGYPIGKDGL LKSVYTGTLL THSHQLASRW IKGHSAGGSR
NTSSYSSNPK FWLKVCETGE VLVSLLQHRK RRNTEKYAQT DPEDSSNTKH QHYQAIALHM
WKVEKKRFSL SRMLNKPPCA STHCHSYERE VVLCRPLEPG FYLLIPSTYQ PGAEAHFLIR
VFSSSPTSLS ALKSPAPSLP LTSDGEWETS FLRGSWIEGR TAGGSRNFPS YWKNPCFPFA
VCDEPALTSG VNVRITLHQS RPDTDLHPIG FHVYKVESEQ TAAKEKDPVA SCIPHCYTQD
VSLACTLPPG SYTIVPSTYH PDCSAKFRIS LARKIHRLAL LSMVLSTVSH ISVMKT
//
