ID M4A5S1_XIPMA Unreviewed; 1942 AA.
AC M4A5S1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Unconventional myosin-X-like {ECO:0000313|Ensembl:ENSXMAP00000009815.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000009815.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000009815.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009815.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 8083.ENSXMAP00000009815; -.
DR Ensembl; ENSXMAT00000009829.2; ENSXMAP00000009815.2; ENSXMAG00000009757.2.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000164909; -.
DR HOGENOM; CLU_001626_1_0_1; -.
DR InParanoid; M4A5S1; -.
DR OMA; NMEFMLA; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0044295; C:axonal growth cone; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17206; FERM_F1_Myosin-X; 1.
DR CDD; cd14873; MYSc_Myo10; 1.
DR CDD; cd13296; PH2_MyoX; 1.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR031971; MYO10_CC.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR040640; MyoX_N_SH3.
DR InterPro; IPR036124; MYSc_Myo10.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF9; UNCONVENTIONAL MYOSIN-X; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF16735; MYO10_CC; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF18597; SH3_19; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 44..719
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1103..1201
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1283..1388
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1426..1585
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1590..1927
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1594..1704
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 598..620
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 776..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 867..894
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 787..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1042
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 138..145
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1942 AA; 222475 MW; 33C4767B55E91344 CRC64;
LPATVNSCGD GTLVVTTDYG EVRSMQRAEV TRERVYAMHQ SSIDGVEDMS ALAELHEAAI
MHNLYQRYQK DNIYTNIGSI LAAVNPYKQI PGLYDLDRVD LYSKHHLGEL PPHIFAVANE
CYRCIWKRHD SQCVLISGES GAGKTESTKL LLQFLSVMSQ NSIAAPQSER TTHVEQAIVQ
SSPIMEAFGN AKTVYNNNSS RFGKFIQLHF SECGNIQGGC VIDCILTNRV VRQNPGERNY
HIFYALLAGA SKEDKSLYFL EDPAESFHYL SQSGCLKDKS LNDKELYNSV MEALKVLGFT
EEEIRDMFKL LSGVLQLGNM EFMLAGGAQI TTKQVVSNAS ELLGLDAFQL SEVLTQRSII
LRGEEICSPL TIEQAIDSRD SVAMALYSQC FSWIILKINQ KIKGKENFKS IGILDIFGFE
NFEVNRFEQF NINYANEKLQ AYFNKHIFSL EQLEYNREGV QWDAIDWMDN AECLDLIEKK
LGLLALVNEE SRFPKGTDFT LLEKLHSRHS TNPYYVKPRV ADHQFGIKHY AGEVLYDVRG
ILEKNRDTFR DDILNMLKDS RLDFIYDLFE KVGSRNNEEK MGTARRKPTV SSQFRDSLHA
LMATLSASNP FFIRCIKPNM EKNPNVFDPE IVLNQLRYSG MLETVKIRRA GFPVRRTFKD
FFSRYKIIIK DKMPAAGDDK KRSTDLLTKY DKTKKEWQLG KTKVFMKESL EQRLEKDRDE
IRRQAAMIIR AHLLTFSAKK HFKQVRSSIV VLQKHLRRHI QRRQFVKKRK AALVLQKHRR
GQVARTHVRK LKEEKKKRED EQRKKEEEEK KNTGAEEDEE VNEDDQKVRS TEASTRLAKI
HPAIDAAAYY PQFELQNVSF SPSLKDEARQ MEEILQLERE IERLQKKRED EVSQLCESSK
QELQLRRDAE LKRMKKEASR KATELIDLLN FGGVDPSAEA VGAKPVAEVK TAKGASTAGG
ASKEEDVDEG FHAEEECIPL PDFPPPAESD APIDQDIFVM VESLVDGEEP IYSMPADTES
DYDQEDEEGN RGSATYADSE DEHDGMMDTD EEVTNGRVTL LNGNGPPYFH GYLYMKAGLM
IPWKRRWCVL KDETFMWFRS KQESLKSGWL YKKGGGLSTL SRRNWKMRWF VLRDSKLMYY
ENDSEEKLKG TIDIRAAKEI VDNHEKENAL NIVTDERTYQ VFAESPEDAS GWFNVLSKVR
VCTPEQLLDM SHEQANPKNA VGTLDVGLID SVCASDNPDR PNSFVIITAN RVIHCNSDTP
EEMHHWISLL QKPKGDARID GQEFLVRGWL HKEMKTNAKS TSLKLKKRWF VLTHNSLDYY
KSAEKNSSKM GTLVLNSLCS VIQPDERVHK ETGYWNIIVY GRKHCYRLYT KMLNEAMRWT
AAILGVIESK TPIETPTLQL IRDIKENSVN AEIVEQMYRR NPILRYTQHP LHSPLLPLPY
GEVTSLHRQQ GYASLQDEAV RVFNSLQEME TLADTVPIIQ GILQTCQDLR PLRDEVYCQV
IKQTNHVPQP NSPANLAHWH LLTCMSCTFL PSRAILRYLR FHLKRVRERY PGTEIERYAS
FIGESLKKTK TREFVPSQEE IAALLLRQEM STTVYCHGGG SCKISINSHT TAGEVVEKLI
RGLAMEDSKN LFSLFEHSSF TDRALESRVI VADVLAKFER LAGSEEDEEE GEWKLYFKLY
CFLDVESMPK EGVEFAFMFE QAHESLISGH FPASEETLQH LAALRLQYLH GDGAGRAGWS
LGSVYPIGRL RNRILQSTKP GVGATPTFRD SSLRKSKTGS LKKQKVEGEQ RLEMWVKEET
SATRTSILEK WTRLQGMPQH QAMLKYMSII KEWPGYGSTL FDVECKEGGF PHDLWLGVSV
DNVSVYKRGE PKPLETFQYE HITFFGASQP CTYKIIVDER EMYFETPQVG EVTKIMKAYI
NMMVKKRCSI MSVTSVASSW AR
//
