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Database: UniProt
Entry: M4A655_XIPMA
LinkDB: M4A655_XIPMA
Original site: M4A655_XIPMA 
ID   M4A655_XIPMA            Unreviewed;       219 AA.
AC   M4A655;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   08-NOV-2023, entry version 57.
DE   RecName: Full=GTP-binding nuclear protein Ran {ECO:0000256|RuleBase:RU363057};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000009949.1, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000009949.1}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000009949.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: GTP-binding protein involved in nucleocytoplasmic transport.
CC       Required for the import of protein into the nucleus and also for RNA
CC       export. Involved in chromatin condensation and control of cell cycle.
CC       {ECO:0000256|RuleBase:RU363057}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU363057}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ran family.
CC       {ECO:0000256|ARBA:ARBA00008028, ECO:0000256|RuleBase:RU363057}.
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DR   RefSeq; XP_005809856.1; XM_005809799.1.
DR   AlphaFoldDB; M4A655; -.
DR   STRING; 8083.ENSXMAP00000009949; -.
DR   Ensembl; ENSXMAT00000009963.2; ENSXMAP00000009949.1; ENSXMAG00000009922.2.
DR   GeneID; 102234897; -.
DR   KEGG; xma:102234897; -.
DR   CTD; 5901; -.
DR   eggNOG; KOG0096; Eukaryota.
DR   GeneTree; ENSGT00940000153786; -.
DR   HOGENOM; CLU_041217_13_0_1; -.
DR   InParanoid; M4A655; -.
DR   OMA; GEIKFDC; -.
DR   OrthoDB; 5471873at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003407; P:neural retina development; IEA:Ensembl.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00877; Ran; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002041; Ran_GTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR24071:SF17; GTP-BINDING NUCLEAR PROTEIN RAN; 1.
DR   PANTHER; PTHR24071; RAN GTPASE; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00627; GTPRANTC4.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00176; RAN; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51418; RAN; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|RuleBase:RU363057};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363057};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU363057};
KW   Protein transport {ECO:0000256|RuleBase:RU363057};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW   Transport {ECO:0000256|RuleBase:RU363057}.
SQ   SEQUENCE   219 AA;  24771 MW;  CA13A78D42BD9F33 CRC64;
     MADSMGQCVP VAVFKLVLVG DGGTGKTTFV KRHITGEFEK KYVATLGVEV HPLMFHTNRG
     PIKYNVWDTA GQEKFGGLRD GYYIQAQCAI IMFDVTSRVT YKNVPNWHRD LVRVCENIPI
     VLCGNKVDIK DRKVKAKSIV FHRKKNLQYY DISAKSNYNF EKPFLWLARK LIGDPNLEFV
     AMPALAPPEV QMDPSLAAKY EEELQVASQT ALPDEEDDL
//
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