ID M4A6V0_XIPMA Unreviewed; 1596 AA.
AC M4A6V0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 {ECO:0000313|Ensembl:ENSXMAP00000010194.2};
GN Name=PREX2 {ECO:0000313|Ensembl:ENSXMAP00000010194.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000010194.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000010194.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000010194.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSXMAT00000010208.2; ENSXMAP00000010194.2; ENSXMAG00000010123.2.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00940000155894; -.
DR HOGENOM; CLU_003935_0_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF1; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 2 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 14..206
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 237..353
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 381..455
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 488..557
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 583..632
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 668..727
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1081..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1596 AA; 181019 MW; DFD335ECA2296C2A CRC64;
IAESGKDQEK QLRLRVCVLN ELLKTERDYV GTLDFLSVSV FLHRLNQYAA TKIDKNITEE
TVKVLFSNIE EILAIHKDFL SMVEELLQPD PHAHHEVGRC FLHFKSRFQI YDEYCGNHEK
AQRLLLELNK IRSVRTCLLN CMLLGGRKNT EVPLEGYLVA PIQRICKYPL LLKELLKRTP
RKHNDHALVQ ESLQVMKAVC SSINEAKRQM EKLEILEEWQ SHIEGWEGSN ITDTCTEMLM
QGVLLKISAG NIQERVFFLF DKLLVYCKRK NRRLKNSKAS SEGPRYQFRG RINTEVMEVE
NVDDGTADYH SSGNIVNNGW KIHNTAKNKW FVCMAKTPEE KQEWLEAIMK ERERRKSLRL
GMEQDTWVMV SEKGEKLYHL MTRGNLIKDR KRKLTTFPKC FLGSEFVSWL MEIGETGNPE
EGVHLGQALL ENGIIHHVTD KHQFKPEPVL YRFRYDDGTY HPRSDMHDVI AKGVRLFCRL
HSLFNPVIRD KDYHLRTYKS VVMANKLIDW LIAQGDCRTR EEALILGVEL CDNGFMHHVL
EKSEFKDEPL LFRFFADEEM EGSNTKHKPL KHDLKIVENV IAKSLLIRPS DGSYGFTLEE
RNRVPIIKCV EKGSAAEMAG LEVGKKLFAI NGDLVFLRPY SEVEVLVRQC FNSKGPLRVL
VSTKPRETIK IPDSADGLGF QIRGFGPSVV HAVGRGTVAA TAGLHPGQCI IKVNGINVSK
ESHASVIAHV TACRKYRRPS QQDTIKWIYN NSESALEENQ KSNQKPTLDE NGDGFEGKVE
EVMDKFNTIA IIDGKKDHVS LTIDNVHLEY GVVYEYDSTA GIKCHVLEKM VEPKGFFSLT
AKILEALARN DDMLLQMCSR LSSSCDVIPD DLQVRFSAMC SERAEHINRR VTNYRKFSRV
LKNRAWPTFK QAKAKVSPLH SSDFCPTNCH INVMEVSYPK TTTSLGSAFG VQLDSRKNSL
EKSARSAGES GKLNPMVNAQ YTITTMAAPS SHSLGRTEGH GLRFLLREDD LLTLDAYQKL
LYKLTAAVKE METHGAHIHD LLSSITYPAA SEVRHPESYI SAESEGEKAE RNGKKVCFNV
TGDEQEDSGH DTISNRDSYS DCNSNRNSIA SFSSICSSHC SSYVHSDDMD SGDEMPSSVW
LSHDKQKKLH SFLEHLFSQV DSITSMLRGA GVARVFEQTK CFTPARGLQE FLQEMEPRVN
CAKKLRLHIK QDPWNLPNSV QGLTQIISKY VEEVKTRLLL VLLQYTDSEI QLRRDMVFCQ
SLVAVVCAFS EHLLAVLNQD FPDPQELQEA QEASRRWLEQ IASAGLLFHF QSLLSPNLTD
EQAMLEDTQV ALIDLEKVTF YFQQFEGEPM VANMPISYQV EGTRQALKVC FYLESYYFAH
LPYRLKNGGG VKIYPVLFTQ ALESMEGYYY RDNVSVEEYQ AQINSSSLEK VKQYNKRLGA
FFLDQSNIPP STAPKAALID KLMRPLNALE ELYRLMESFI SCRRTAACQF TACGASGVGL
LTVASELCSR LGATHVVMCN SGVHRCTLSV TLEQAILLAR NHGLPPRCIM QATDVMRKQG
ARVQNSAKNL GVRDRTPSSV PRLYKLCQPP PPDGDP
//
